CN104447598A - Ca-4的大环多胺衍生物及其抗肿瘤特性 - Google Patents
Ca-4的大环多胺衍生物及其抗肿瘤特性 Download PDFInfo
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- CN104447598A CN104447598A CN201310428519.5A CN201310428519A CN104447598A CN 104447598 A CN104447598 A CN 104447598A CN 201310428519 A CN201310428519 A CN 201310428519A CN 104447598 A CN104447598 A CN 104447598A
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- 0 COc1cc(C=C[C@]2C=C(*)C(O*)=CC2)cc(OC)c1OC Chemical compound COc1cc(C=C[C@]2C=C(*)C(O*)=CC2)cc(OC)c1OC 0.000 description 9
- SPHWDDXYTLCCCS-YPKPFQOOSA-N CCCC(CCC(C1)/C=C\C(CC2CC)CC(CC)=C2OC)C1OC(CN1CCN(CC2=CCCC2C)CCNCC1)O Chemical compound CCCC(CCC(C1)/C=C\C(CC2CC)CC(CC)=C2OC)C1OC(CN1CCN(CC2=CCCC2C)CCNCC1)O SPHWDDXYTLCCCS-YPKPFQOOSA-N 0.000 description 1
- HVXBOLULGPECHP-WAYWQWQTSA-N COc(ccc(/C=C\c(cc1OC)cc(OC)c1OC)c1)c1O Chemical compound COc(ccc(/C=C\c(cc1OC)cc(OC)c1OC)c1)c1O HVXBOLULGPECHP-WAYWQWQTSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D255/00—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00
- C07D255/02—Heterocyclic compounds containing rings having three nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D249/00 - C07D253/00 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310428519.5A CN104447598B (zh) | 2013-09-18 | 2013-09-18 | Ca‑4的大环多胺衍生物及其抗肿瘤特性 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310428519.5A CN104447598B (zh) | 2013-09-18 | 2013-09-18 | Ca‑4的大环多胺衍生物及其抗肿瘤特性 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104447598A true CN104447598A (zh) | 2015-03-25 |
| CN104447598B CN104447598B (zh) | 2017-09-22 |
Family
ID=52894425
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310428519.5A Active CN104447598B (zh) | 2013-09-18 | 2013-09-18 | Ca‑4的大环多胺衍生物及其抗肿瘤特性 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104447598B (it) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018051197A1 (en) * | 2016-09-19 | 2018-03-22 | The Hong Kong Polytechnic University | Chiral cyclen compounds and their uses |
| EP3564218A4 (en) * | 2016-12-30 | 2019-12-18 | Viwit Pharmaceutical Co., Ltd. | METHOD FOR PRODUCING 1,4,7,10-TETRAAZACYCLODODECAN-1,4,7,10-TETRAIC ACID |
| WO2020161308A1 (fr) * | 2019-02-08 | 2020-08-13 | Centre National De La Recherche Scientifique | Nouveaux dérivés azobenzènes, leur procédé de préparation et leur utilisation pour le traitement thérapeutique associé à des radiations ionisantes |
| WO2022100487A1 (zh) * | 2020-11-13 | 2022-05-19 | 义乌市华耀医药科技有限公司 | 氨基康普立停衍生物及其应用 |
| CN115403483A (zh) * | 2021-07-02 | 2022-11-29 | 河南省儿童医院郑州儿童医院 | 含二苯乙烯或二苯甲酮骨架的ca-4衍生物、药物组合物及其制备方法和应用 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1465580A (zh) * | 2002-06-07 | 2004-01-07 | 深圳市北大高科技股份有限公司 | 一种简便合成康普立停a-4前药的方法 |
| US20070270617A1 (en) * | 2000-09-14 | 2007-11-22 | Venit John J | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di-amino acid salts, and mono- and di-amino acid ester salts |
| CN101085743A (zh) * | 2006-06-06 | 2007-12-12 | 浙江大德药业集团有限公司 | 含氟烷氧基康普立停衍生物及制法和用途 |
| CN101139358A (zh) * | 2006-09-07 | 2008-03-12 | 浙江大德药业集团有限公司 | 乙氧基康普立停及其前药的制备和用途 |
| WO2009118474A1 (fr) * | 2008-02-28 | 2009-10-01 | Sanofi-Aventis | Procede de preparation de combretastatine |
| CN103012248A (zh) * | 2013-01-11 | 2013-04-03 | 浙江大德药业集团有限公司 | 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用 |
-
2013
- 2013-09-18 CN CN201310428519.5A patent/CN104447598B/zh active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070270617A1 (en) * | 2000-09-14 | 2007-11-22 | Venit John J | Combretastatin A-4 phosphate prodrug mono- and di-organic amine salts, mono- and di-amino acid salts, and mono- and di-amino acid ester salts |
| CN1465580A (zh) * | 2002-06-07 | 2004-01-07 | 深圳市北大高科技股份有限公司 | 一种简便合成康普立停a-4前药的方法 |
| CN101085743A (zh) * | 2006-06-06 | 2007-12-12 | 浙江大德药业集团有限公司 | 含氟烷氧基康普立停衍生物及制法和用途 |
| CN101139358A (zh) * | 2006-09-07 | 2008-03-12 | 浙江大德药业集团有限公司 | 乙氧基康普立停及其前药的制备和用途 |
| WO2009118474A1 (fr) * | 2008-02-28 | 2009-10-01 | Sanofi-Aventis | Procede de preparation de combretastatine |
| CN103012248A (zh) * | 2013-01-11 | 2013-04-03 | 浙江大德药业集团有限公司 | 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用 |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018051197A1 (en) * | 2016-09-19 | 2018-03-22 | The Hong Kong Polytechnic University | Chiral cyclen compounds and their uses |
| CN109963839A (zh) * | 2016-09-19 | 2019-07-02 | 香港理工大学 | 手性轮环藤宁化合物及其用途 |
| US11357873B2 (en) | 2016-09-19 | 2022-06-14 | The Hong Kong Polytechnic University | Chiral cyclen compounds and their uses |
| EP3564218A4 (en) * | 2016-12-30 | 2019-12-18 | Viwit Pharmaceutical Co., Ltd. | METHOD FOR PRODUCING 1,4,7,10-TETRAAZACYCLODODECAN-1,4,7,10-TETRAIC ACID |
| US11214553B2 (en) | 2016-12-30 | 2022-01-04 | Viwit Pharmaceutical Co., Ltd. | Method for preparing 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid |
| WO2020161308A1 (fr) * | 2019-02-08 | 2020-08-13 | Centre National De La Recherche Scientifique | Nouveaux dérivés azobenzènes, leur procédé de préparation et leur utilisation pour le traitement thérapeutique associé à des radiations ionisantes |
| FR3092580A1 (fr) * | 2019-02-08 | 2020-08-14 | Centre National De La Recherche Scientifique | Nouveaux dérivés azobenzènes, leur procédé de préparation et leur utilisation pour le traitement thérapeutique associé à des radiations ionisantes |
| CN113710676A (zh) * | 2019-02-08 | 2021-11-26 | 国家科学研究中心 | 新型偶氮苯衍生物、其制备方法及其在与电离辐射联合的治疗性治疗中的用途 |
| WO2022100487A1 (zh) * | 2020-11-13 | 2022-05-19 | 义乌市华耀医药科技有限公司 | 氨基康普立停衍生物及其应用 |
| CN115403483A (zh) * | 2021-07-02 | 2022-11-29 | 河南省儿童医院郑州儿童医院 | 含二苯乙烯或二苯甲酮骨架的ca-4衍生物、药物组合物及其制备方法和应用 |
| CN115403483B (zh) * | 2021-07-02 | 2024-01-26 | 河南省儿童医院郑州儿童医院 | 含二苯乙烯或二苯甲酮骨架的ca-4衍生物、药物组合物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104447598B (zh) | 2017-09-22 |
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Legal Events
| Date | Code | Title | Description |
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| C06 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Macrocyclic polyamine derivatives of CA-4 and their antitumor properties Effective date of registration: 20220110 Granted publication date: 20170922 Pledgee: Zhejiang Yiwu Rural Commercial Bank Co.,Ltd. Pledgor: ZHEJIANG DADE PHARMACEUTICAL GROUP Co.,Ltd. Registration number: Y2022330000037 |
|
| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20230104 Granted publication date: 20170922 Pledgee: Zhejiang Yiwu Rural Commercial Bank Co.,Ltd. Pledgor: ZHEJIANG DADE PHARMACEUTICAL GROUP Co.,Ltd. Registration number: Y2022330000037 |