CN104447473A - 依折麦布中间体的制备方法 - Google Patents

依折麦布中间体的制备方法 Download PDF

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Publication number
CN104447473A
CN104447473A CN201410623650.1A CN201410623650A CN104447473A CN 104447473 A CN104447473 A CN 104447473A CN 201410623650 A CN201410623650 A CN 201410623650A CN 104447473 A CN104447473 A CN 104447473A
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CN
China
Prior art keywords
preparation
ezetimibe
ezetimibe intermediate
methylene dichloride
add
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CN201410623650.1A
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English (en)
Chinese (zh)
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CN104447473B (zh
Inventor
田兴华
晏柳清
李建惠
赵智程
罗丹
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Huzhou lingchuang Technology Co., Ltd
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CHENGDU SENKE PHARMACEUTICAL Co Ltd
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Priority to CN201410623650.1A priority Critical patent/CN104447473B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
CN201410623650.1A 2014-11-06 2014-11-06 依折麦布中间体的制备方法 Active CN104447473B (zh)

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CN201410623650.1A CN104447473B (zh) 2014-11-06 2014-11-06 依折麦布中间体的制备方法

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CN201410623650.1A CN104447473B (zh) 2014-11-06 2014-11-06 依折麦布中间体的制备方法

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CN104447473A true CN104447473A (zh) 2015-03-25
CN104447473B CN104447473B (zh) 2016-11-16

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105017119A (zh) * 2015-07-23 2015-11-04 青岛蓝盛洋医药生物科技有限责任公司 一种降血脂药物依折麦布化合物

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007119106A2 (en) * 2005-12-22 2007-10-25 Medichem, S.A. Processes for preparing intermediate compounds useful for the preparation of ezetimibe
WO2008096372A2 (en) * 2007-02-06 2008-08-14 Ind-Swift Laboratories Limited Process for preparing highly pure ezetimibe using novel intermediates
WO2010097350A1 (en) * 2009-02-24 2010-09-02 Adamed Sp. Z O.O. A process for the preparation of an aldehyde beta-lactam compound
CN102531986A (zh) * 2012-02-23 2012-07-04 苏州朗科生物技术有限公司 一种依替米贝的制备方法
CN102775366A (zh) * 2011-05-10 2012-11-14 上海医药工业研究院 3-(5-甲氧基-1,5-二氧代戊基)-(4s)-苯基噁唑烷-2-酮的制备方法
CN102952055A (zh) * 2011-08-16 2013-03-06 凯瑞斯德生化(苏州)有限公司 一种依泽替米贝和其中间体的制备方法
CN103086938A (zh) * 2011-10-28 2013-05-08 沈阳药科大学 依泽替米贝的合成方法
CN103755616A (zh) * 2013-12-31 2014-04-30 北京万全德众医药生物技术有限公司 一种制备依泽替米贝异构体的方法
CN104059009A (zh) * 2013-03-21 2014-09-24 四川金辉药业有限公司 一种依折麦布重要中间体的合成方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007119106A2 (en) * 2005-12-22 2007-10-25 Medichem, S.A. Processes for preparing intermediate compounds useful for the preparation of ezetimibe
WO2008096372A2 (en) * 2007-02-06 2008-08-14 Ind-Swift Laboratories Limited Process for preparing highly pure ezetimibe using novel intermediates
WO2010097350A1 (en) * 2009-02-24 2010-09-02 Adamed Sp. Z O.O. A process for the preparation of an aldehyde beta-lactam compound
CN102775366A (zh) * 2011-05-10 2012-11-14 上海医药工业研究院 3-(5-甲氧基-1,5-二氧代戊基)-(4s)-苯基噁唑烷-2-酮的制备方法
CN102952055A (zh) * 2011-08-16 2013-03-06 凯瑞斯德生化(苏州)有限公司 一种依泽替米贝和其中间体的制备方法
CN103086938A (zh) * 2011-10-28 2013-05-08 沈阳药科大学 依泽替米贝的合成方法
CN102531986A (zh) * 2012-02-23 2012-07-04 苏州朗科生物技术有限公司 一种依替米贝的制备方法
CN104059009A (zh) * 2013-03-21 2014-09-24 四川金辉药业有限公司 一种依折麦布重要中间体的合成方法
CN103755616A (zh) * 2013-12-31 2014-04-30 北京万全德众医药生物技术有限公司 一种制备依泽替米贝异构体的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
C.H.V.A.SASIKALA等: "An Improved and Scalable Process for the Synthesis of Ezetimibe: An Antihypercholesterolemia Drug", 《ORGANIC PROCESS RESEARCH & DEVELOPMENT》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105017119A (zh) * 2015-07-23 2015-11-04 青岛蓝盛洋医药生物科技有限责任公司 一种降血脂药物依折麦布化合物

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Effective date of registration: 20191118

Address after: 620000 No. 6, Xiang Zhang Road, new economic development zone, Meishan, Sichuan

Patentee after: Sichuan Senke Pharmaceutical Co. Ltd.

Address before: 610500, No. 145 East Street, new town, Xindu District, Sichuan, Chengdu

Patentee before: CHENGDU SENKE PHARMACEUTICAL CO., LTD.

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20210111

Address after: Room 406, no.3020 Huling Road, Linghu Town, Nanxun District, Huzhou City, Zhejiang Province

Patentee after: Huzhou lingchuang Technology Co., Ltd

Address before: 6 Xiangzhang Road, new economic development zone, Meishan, Sichuan 620000

Patentee before: SICHUAN SENKE PHARMACEUTICAL Co.,Ltd.

TR01 Transfer of patent right