CN104262229A - 一种2-苯基取代-3-苯甲酰基取代吲哚的制备方法 - Google Patents

一种2-苯基取代-3-苯甲酰基取代吲哚的制备方法 Download PDF

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Publication number
CN104262229A
CN104262229A CN201410417908.2A CN201410417908A CN104262229A CN 104262229 A CN104262229 A CN 104262229A CN 201410417908 A CN201410417908 A CN 201410417908A CN 104262229 A CN104262229 A CN 104262229A
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reaction
solvent
dmso
dimethyl sulfoxide
thf
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CN201410417908.2A
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Chinese (zh)
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CN104262229B (zh
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孙青�
张卫东
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Shandong Yi Tatsu Medical Technology Co Ltd
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SHANDONG XIER KANGTAI PHARMACEUTICAL CO Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
CN201410417908.2A 2014-08-18 2014-08-18 一种2-苯基取代-3-苯甲酰基取代吲哚的制备方法 Active CN104262229B (zh)

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CN201410417908.2A CN104262229B (zh) 2014-08-18 2014-08-18 一种2-苯基取代-3-苯甲酰基取代吲哚的制备方法

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CN201410417908.2A CN104262229B (zh) 2014-08-18 2014-08-18 一种2-苯基取代-3-苯甲酰基取代吲哚的制备方法

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CN104262229A true CN104262229A (zh) 2015-01-07
CN104262229B CN104262229B (zh) 2016-10-05

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001019794A2 (en) * 1999-09-17 2001-03-22 Baylor University Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents
WO2002060872A1 (en) * 2001-02-01 2002-08-08 The Australian National University Synthesis for the preparation of compounds for screening as potential tubulin binding agents
WO2004099139A1 (en) * 2000-09-15 2004-11-18 Baylor University Indole-containing compounds with anti-tubulin and vascular targeting activity

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001019794A2 (en) * 1999-09-17 2001-03-22 Baylor University Indole-containing and combretastatin-related anti-mitotic and anti-tubulin polymerization agents
US20070082872A1 (en) * 1999-09-17 2007-04-12 Pinney Kevin G Indole-containing compounds with anti-tubulin and vascular targeting activity
WO2004099139A1 (en) * 2000-09-15 2004-11-18 Baylor University Indole-containing compounds with anti-tubulin and vascular targeting activity
WO2002060872A1 (en) * 2001-02-01 2002-08-08 The Australian National University Synthesis for the preparation of compounds for screening as potential tubulin binding agents

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BERNARD L. FLYNN，等: "One-Pot Synthesis of Benzo[b]furan and Indole Inhibitors of Tubulin Polymerization", 《J. MED. CHEM.》 *
HU YUAN，等: "Construction of 2-Substituted-3-Functionalized Benzofurans via Intramolecular Heck Coupling: Application to Enantioselective Total Synthesis of Daphnodorin B", 《ORGANIC LETTERS》 *
MALLINATH B. HADIMANI，等: "Synthesis of a 2-Aryl-3-aroyl Indole Salt (OXi8007) Resembling Combretastatin A-4 with Application as a Vascular Disrupting Agent", 《J. NAT. PROD.》 *
MATTHEW T. MACDONOUGH，等: "Synthesis and biological evaluation of indole-based, anti-cancer agents inspired by the vascular disrupting agent 2-(3’-hydroxy-4’-methoxyphenyl)-3-(3’’,4’’,5’’-trimethoxybenzoyl)-6-methoxyindole", 《BIOORGANIC & MEDICINAL CHEMISTRY》 *
李洪雪，等: "考布他丁A-4磷酸盐前药：CA4P", 《中国新药与临床杂志》 *
杨晓梅，等: "还原型Heck反应的研究进展", 《有机化学》 *

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