CN103936564B - 泊沙康唑中间体（2s，3r）-2-苄氧基-3-戊醇的制备方法 - Google Patents

泊沙康唑中间体（2s，3r）-2-苄氧基-3-戊醇的制备方法 Download PDF

Info

Publication number
CN103936564B
CN103936564B CN201410121622.XA CN201410121622A CN103936564B CN 103936564 B CN103936564 B CN 103936564B CN 201410121622 A CN201410121622 A CN 201410121622A CN 103936564 B CN103936564 B CN 103936564B
Authority
CN
China
Prior art keywords
benzyloxy
propione
reaction
cbs
amylalcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201410121622.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN103936564A (zh
Inventor
桑媛
张颖
刘元鑫
刘鹏
孙丽梦
李洪爽
孙健
王学斌
曲延伟
朱玉正
杨延昆
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
JINAN KANGHE MEDICAL TECHNOLOGY Co Ltd
Original Assignee
JINAN KANGHE MEDICAL TECHNOLOGY Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JINAN KANGHE MEDICAL TECHNOLOGY Co Ltd filed Critical JINAN KANGHE MEDICAL TECHNOLOGY Co Ltd
Priority to CN201410121622.XA priority Critical patent/CN103936564B/zh
Publication of CN103936564A publication Critical patent/CN103936564A/zh
Application granted granted Critical
Publication of CN103936564B publication Critical patent/CN103936564B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
CN201410121622.XA 2014-03-28 2014-03-28 泊沙康唑中间体（2s，3r）-2-苄氧基-3-戊醇的制备方法 Expired - Fee Related CN103936564B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201410121622.XA CN103936564B (zh) 2014-03-28 2014-03-28 泊沙康唑中间体（2s，3r）-2-苄氧基-3-戊醇的制备方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201410121622.XA CN103936564B (zh) 2014-03-28 2014-03-28 泊沙康唑中间体（2s，3r）-2-苄氧基-3-戊醇的制备方法

Publications (2)

Publication Number Publication Date
CN103936564A CN103936564A (zh) 2014-07-23
CN103936564B true CN103936564B (zh) 2016-05-11

Family

ID=51184486

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201410121622.XA Expired - Fee Related CN103936564B (zh) 2014-03-28 2014-03-28 泊沙康唑中间体（2s，3r）-2-苄氧基-3-戊醇的制备方法

Country Status (1)

Country Link
CN (1) CN103936564B (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108084049B (zh) * 2016-11-21 2020-09-25 重庆圣华曦药业股份有限公司 一种泊沙康唑中间体的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033178A1 (en) * 1995-04-19 1996-10-24 Schering Corporation Process for the preparation of triazolones
CN101412687A (zh) * 2008-11-10 2009-04-22 浙江师范大学 旋光纯富马酸伊布利特的制备方法
CN102775366A (zh) * 2011-05-10 2012-11-14 上海医药工业研究院 3-(5-甲氧基-1,5-二氧代戊基)-(4s)-苯基噁唑烷-2-酮的制备方法
CN103193609A (zh) * 2013-03-27 2013-07-10 浙江丽晶化学有限公司 (s)-2-苄氧基戊-3-酮的合成工艺
CN103635465A (zh) * 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033178A1 (en) * 1995-04-19 1996-10-24 Schering Corporation Process for the preparation of triazolones
CN101412687A (zh) * 2008-11-10 2009-04-22 浙江师范大学 旋光纯富马酸伊布利特的制备方法
CN102775366A (zh) * 2011-05-10 2012-11-14 上海医药工业研究院 3-(5-甲氧基-1,5-二氧代戊基)-(4s)-苯基噁唑烷-2-酮的制备方法
CN103635465A (zh) * 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法
CN103193609A (zh) * 2013-03-27 2013-07-10 浙江丽晶化学有限公司 (s)-2-苄氧基戊-3-酮的合成工艺

Also Published As

Publication number Publication date
CN103936564A (zh) 2014-07-23

Similar Documents

Publication Publication Date Title
CN106928214A (zh) 一种噁唑烷酮类化合物及其中间体的制备方法
CN112300212A (zh) 硼烷-吡啶络合物在制备nk-1受体拮抗剂中的用途
WO2023284058A1 (zh) 一种手性合成尼古丁的制备方法
CN103936564B (zh) 泊沙康唑中间体（2s，3r）-2-苄氧基-3-戊醇的制备方法
CN105622591A (zh) 一种新型三唑类抗真菌药物的制备方法
CN105524064A (zh) 恩替卡韦的合成方法
CN103864630B (zh) (s)-1-(4-乙氧基苄基)-3-氮杂戊烷-1,5-二胺三盐酸盐的合成方法
CN103044468B (zh) N-(2-吡嗪羰基)-l-苯丙氨酸-l-亮氨酸硼酸的制备方法
CN102746235B (zh) 一种改进的制备咪达那新的方法
CN102603603B (zh) 一种制备（s）-奥拉西坦的方法
CN102718662A (zh) 一种制备盐酸西那卡塞的方法
CN102070513B (zh) 1-叔丁氧羰基-4-哌啶酮的合成方法
CN102603594B (zh) （s）-奥拉西坦的制备方法
CN104326927B (zh) 一种1-[2-氨基-1-(4-甲氧基苯基)乙基]环己醇硫酸盐的制备方法
CN107987097A (zh) 2,6-二氯吡啶-4-硼酸频那醇酯的合成工艺
CN103193609B (zh) (s)-2-苄氧基戊-3-酮的合成工艺
CN112480172A (zh) 硼烷-吡啶络合物在制备药物化合物中的用途
CN106748816A (zh) 一种度鲁特韦关键中间体(r)‑3‑氨基丁醇的合成方法
CN112552345A (zh) 一种nk-1受体拮抗剂的制备方法
CN104672180A (zh) 一种[(1s)-3-甲基-1-[[(2r)-2-甲基环氧乙基]羰基]丁基]氨基甲酸叔丁酯的手性制备方法
CN112521421A (zh) 一种药物化合物的制备方法
CN104447562A (zh) 一种制备盐酸右美托咪定关键中间体的新方法
CN104230723A (zh) 托瑞米芬的合成方法
CN106947792A (zh) 一种间甲砜基‑l‑苯丙氨酸的制备方法
CN103373954B (zh) 一种1-苄基-4-甲氧甲基-4-苯胺基哌啶盐酸盐的制备方法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
CB03 Change of inventor or designer information

Inventor after: Sang Yuan

Inventor after: Zhu Yuzheng

Inventor after: Yang Yankun

Inventor after: Zhang Ying

Inventor after: Liu Yuanxin

Inventor after: Liu Peng

Inventor after: Sun Limeng

Inventor after: Li Hongshuang

Inventor after: Sun Jian

Inventor after: Wang Xuebin

Inventor after: Qu Yanwei

Inventor before: Zhang Ying

Inventor before: Yang Yankun

Inventor before: Liu Yuanxin

Inventor before: Liu Peng

Inventor before: Sun Limeng

Inventor before: Li Hongshuang

Inventor before: Sun Jian

Inventor before: Wang Xuebin

Inventor before: Qu Yanwei

Inventor before: Zhu Yuzheng

COR Change of bibliographic data
C14 Grant of patent or utility model
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160511

Termination date: 20210328

CF01 Termination of patent right due to non-payment of annual fee