CN103936564A - 泊沙康唑中间体(2s,3r)-2-苄氧基-3-戊醇的制备方法 - Google Patents
泊沙康唑中间体(2s,3r)-2-苄氧基-3-戊醇的制备方法 Download PDFInfo
- Publication number
- CN103936564A CN103936564A CN201410121622.XA CN201410121622A CN103936564A CN 103936564 A CN103936564 A CN 103936564A CN 201410121622 A CN201410121622 A CN 201410121622A CN 103936564 A CN103936564 A CN 103936564A
- Authority
- CN
- China
- Prior art keywords
- benzyloxy
- amylalcohol
- reaction
- propione
- thf
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C[C@](*)C(C1ICCCC1)=O Chemical compound C[C@](*)C(C1ICCCC1)=O 0.000 description 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
- C07C41/26—Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/54—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410121622.XA CN103936564B (zh) | 2014-03-28 | 2014-03-28 | 泊沙康唑中间体(2s,3r)-2-苄氧基-3-戊醇的制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410121622.XA CN103936564B (zh) | 2014-03-28 | 2014-03-28 | 泊沙康唑中间体(2s,3r)-2-苄氧基-3-戊醇的制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103936564A true CN103936564A (zh) | 2014-07-23 |
CN103936564B CN103936564B (zh) | 2016-05-11 |
Family
ID=51184486
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410121622.XA Expired - Fee Related CN103936564B (zh) | 2014-03-28 | 2014-03-28 | 泊沙康唑中间体(2s,3r)-2-苄氧基-3-戊醇的制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN103936564B (it) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108084049A (zh) * | 2016-11-21 | 2018-05-29 | 重庆圣华曦药业股份有限公司 | 一种泊沙康唑中间体的制备方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996033178A1 (en) * | 1995-04-19 | 1996-10-24 | Schering Corporation | Process for the preparation of triazolones |
CN101412687A (zh) * | 2008-11-10 | 2009-04-22 | 浙江师范大学 | 旋光纯富马酸伊布利特的制备方法 |
CN102775366A (zh) * | 2011-05-10 | 2012-11-14 | 上海医药工业研究院 | 3-(5-甲氧基-1,5-二氧代戊基)-(4s)-苯基噁唑烷-2-酮的制备方法 |
CN103193609A (zh) * | 2013-03-27 | 2013-07-10 | 浙江丽晶化学有限公司 | (s)-2-苄氧基戊-3-酮的合成工艺 |
CN103635465A (zh) * | 2011-06-16 | 2014-03-12 | 桑多斯股份公司 | 制备手性化合物的方法 |
-
2014
- 2014-03-28 CN CN201410121622.XA patent/CN103936564B/zh not_active Expired - Fee Related
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996033178A1 (en) * | 1995-04-19 | 1996-10-24 | Schering Corporation | Process for the preparation of triazolones |
CN101412687A (zh) * | 2008-11-10 | 2009-04-22 | 浙江师范大学 | 旋光纯富马酸伊布利特的制备方法 |
CN102775366A (zh) * | 2011-05-10 | 2012-11-14 | 上海医药工业研究院 | 3-(5-甲氧基-1,5-二氧代戊基)-(4s)-苯基噁唑烷-2-酮的制备方法 |
CN103635465A (zh) * | 2011-06-16 | 2014-03-12 | 桑多斯股份公司 | 制备手性化合物的方法 |
CN103193609A (zh) * | 2013-03-27 | 2013-07-10 | 浙江丽晶化学有限公司 | (s)-2-苄氧基戊-3-酮的合成工艺 |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108084049A (zh) * | 2016-11-21 | 2018-05-29 | 重庆圣华曦药业股份有限公司 | 一种泊沙康唑中间体的制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN103936564B (zh) | 2016-05-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103880596B (zh) | 一种适合工业化生产的硝酸布康唑中间体的制备方法 | |
CN110467591A (zh) | 稀土金属配合物促进的一锅法合成化妆品活性物玻色因 | |
CN110092757A (zh) | 一种安全可靠的咪鲜胺的制备方法 | |
CN112300212A (zh) | 硼烷-吡啶络合物在制备nk-1受体拮抗剂中的用途 | |
CN105254567A (zh) | 一种制备盐酸右美托咪定关键中间体的方法 | |
CN103936564B (zh) | 泊沙康唑中间体(2s,3r)-2-苄氧基-3-戊醇的制备方法 | |
CN102746235B (zh) | 一种改进的制备咪达那新的方法 | |
CN102603603B (zh) | 一种制备(s)-奥拉西坦的方法 | |
CN102241630A (zh) | 一种镇咳嗽药磷酸二甲啡烷的制备方法 | |
CN102432594B (zh) | 一种药物中间体1-(3-羟甲基吡啶-2-基)-2-苯基-4-甲基哌嗪的制备方法 | |
CN103896858B (zh) | 胞嘧啶的制备工艺 | |
CN102718662A (zh) | 一种制备盐酸西那卡塞的方法 | |
CN103044468A (zh) | N-(2-吡嗪羰基)-l-苯丙氨酸-l-亮氨酸硼酸的制备方法 | |
CN102070513B (zh) | 1-叔丁氧羰基-4-哌啶酮的合成方法 | |
CN112480172A (zh) | 硼烷-吡啶络合物在制备药物化合物中的用途 | |
CN103896859B (zh) | 合成胞嘧啶的工艺 | |
CN109053585B (zh) | 一种三氯苯达唑的合成方法 | |
CN103193609B (zh) | (s)-2-苄氧基戊-3-酮的合成工艺 | |
CN106749116A (zh) | 一种3‑氨基甲基四氢呋喃的制备方法 | |
CN106748816A (zh) | 一种度鲁特韦关键中间体(r)‑3‑氨基丁醇的合成方法 | |
CN104672180A (zh) | 一种[(1s)-3-甲基-1-[[(2r)-2-甲基环氧乙基]羰基]丁基]氨基甲酸叔丁酯的手性制备方法 | |
CN112552345A (zh) | 一种nk-1受体拮抗剂的制备方法 | |
CN105237340A (zh) | 4,4,4-三氟丁醇的合成新方法 | |
CN112521421A (zh) | 一种药物化合物的制备方法 | |
CN102603600A (zh) | 一种制备(s)-奥拉西坦的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
CB03 | Change of inventor or designer information |
Inventor after: Sang Yuan Inventor after: Zhu Yuzheng Inventor after: Yang Yankun Inventor after: Zhang Ying Inventor after: Liu Yuanxin Inventor after: Liu Peng Inventor after: Sun Limeng Inventor after: Li Hongshuang Inventor after: Sun Jian Inventor after: Wang Xuebin Inventor after: Qu Yanwei Inventor before: Zhang Ying Inventor before: Yang Yankun Inventor before: Liu Yuanxin Inventor before: Liu Peng Inventor before: Sun Limeng Inventor before: Li Hongshuang Inventor before: Sun Jian Inventor before: Wang Xuebin Inventor before: Qu Yanwei Inventor before: Zhu Yuzheng |
|
COR | Change of bibliographic data | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160511 Termination date: 20210328 |
|
CF01 | Termination of patent right due to non-payment of annual fee |