CN103936564A - 泊沙康唑中间体(2s,3r)-2-苄氧基-3-戊醇的制备方法 - Google Patents

泊沙康唑中间体(2s,3r)-2-苄氧基-3-戊醇的制备方法 Download PDF

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Publication number
CN103936564A
CN103936564A CN201410121622.XA CN201410121622A CN103936564A CN 103936564 A CN103936564 A CN 103936564A CN 201410121622 A CN201410121622 A CN 201410121622A CN 103936564 A CN103936564 A CN 103936564A
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Prior art keywords
benzyloxy
amylalcohol
reaction
propione
thf
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CN201410121622.XA
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English (en)
Chinese (zh)
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CN103936564B (zh
Inventor
张颖
刘元鑫
刘鹏
孙丽梦
李洪爽
孙健
王学斌
曲延伟
朱玉正
杨延昆
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JINAN KANGHE MEDICAL TECHNOLOGY Co Ltd
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JINAN KANGHE MEDICAL TECHNOLOGY Co Ltd
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Priority to CN201410121622.XA priority Critical patent/CN103936564B/zh
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/18Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/26Preparation of ethers by reactions not forming ether-oxygen bonds by introduction of hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/54Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition of compounds containing doubly bound oxygen atoms, e.g. esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
CN201410121622.XA 2014-03-28 2014-03-28 泊沙康唑中间体(2s,3r)-2-苄氧基-3-戊醇的制备方法 Expired - Fee Related CN103936564B (zh)

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CN201410121622.XA CN103936564B (zh) 2014-03-28 2014-03-28 泊沙康唑中间体(2s,3r)-2-苄氧基-3-戊醇的制备方法

Applications Claiming Priority (1)

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CN201410121622.XA CN103936564B (zh) 2014-03-28 2014-03-28 泊沙康唑中间体(2s,3r)-2-苄氧基-3-戊醇的制备方法

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CN103936564A true CN103936564A (zh) 2014-07-23
CN103936564B CN103936564B (zh) 2016-05-11

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108084049A (zh) * 2016-11-21 2018-05-29 重庆圣华曦药业股份有限公司 一种泊沙康唑中间体的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033178A1 (en) * 1995-04-19 1996-10-24 Schering Corporation Process for the preparation of triazolones
CN101412687A (zh) * 2008-11-10 2009-04-22 浙江师范大学 旋光纯富马酸伊布利特的制备方法
CN102775366A (zh) * 2011-05-10 2012-11-14 上海医药工业研究院 3-(5-甲氧基-1,5-二氧代戊基)-(4s)-苯基噁唑烷-2-酮的制备方法
CN103193609A (zh) * 2013-03-27 2013-07-10 浙江丽晶化学有限公司 (s)-2-苄氧基戊-3-酮的合成工艺
CN103635465A (zh) * 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996033178A1 (en) * 1995-04-19 1996-10-24 Schering Corporation Process for the preparation of triazolones
CN101412687A (zh) * 2008-11-10 2009-04-22 浙江师范大学 旋光纯富马酸伊布利特的制备方法
CN102775366A (zh) * 2011-05-10 2012-11-14 上海医药工业研究院 3-(5-甲氧基-1,5-二氧代戊基)-(4s)-苯基噁唑烷-2-酮的制备方法
CN103635465A (zh) * 2011-06-16 2014-03-12 桑多斯股份公司 制备手性化合物的方法
CN103193609A (zh) * 2013-03-27 2013-07-10 浙江丽晶化学有限公司 (s)-2-苄氧基戊-3-酮的合成工艺

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108084049A (zh) * 2016-11-21 2018-05-29 重庆圣华曦药业股份有限公司 一种泊沙康唑中间体的制备方法

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Inventor after: Liu Peng

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Inventor after: Li Hongshuang

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