CN103848778A - 一种氨肽酶n抑制剂及其制备方法与应用 - Google Patents

一种氨肽酶n抑制剂及其制备方法与应用 Download PDF

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Publication number
CN103848778A
CN103848778A CN201410123847.9A CN201410123847A CN103848778A CN 103848778 A CN103848778 A CN 103848778A CN 201410123847 A CN201410123847 A CN 201410123847A CN 103848778 A CN103848778 A CN 103848778A
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China
Prior art keywords
aminopeptidase
compound
inhibitor
cell
preparation
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CN201410123847.9A
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Chinese (zh)
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CN103848778B (zh
Inventor
张晓攀
马文泉
徐文方
刘刚
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WEIFANG HIGH-TECH BIOLOGICAL PARK DEVELOPMENT Co Ltd
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WEIFANG HIGH-TECH BIOLOGICAL PARK DEVELOPMENT Co Ltd
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/86Oxygen atoms
    • C07D211/88Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
CN201410123847.9A 2014-03-28 2014-03-28 一种氨肽酶n抑制剂及其制备方法与应用 Expired - Fee Related CN103848778B (zh)

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CN201410123847.9A CN103848778B (zh) 2014-03-28 2014-03-28 一种氨肽酶n抑制剂及其制备方法与应用

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CN201410123847.9A CN103848778B (zh) 2014-03-28 2014-03-28 一种氨肽酶n抑制剂及其制备方法与应用

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CN103848778A true CN103848778A (zh) 2014-06-11
CN103848778B CN103848778B (zh) 2016-01-06

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108977498A (zh) * 2018-06-19 2018-12-11 潍坊医学院 一种氨肽酶n抑制剂的抑酶活性测定方法及应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1974554A (zh) * 2006-12-12 2007-06-06 山东大学 环酰亚胺类肽金属蛋白酶抑制剂及其应用
CN101538311A (zh) * 2009-04-16 2009-09-23 山东大学 α-氨基酰环酰亚胺类肽金属蛋白酶抑制剂及其应用

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1974554A (zh) * 2006-12-12 2007-06-06 山东大学 环酰亚胺类肽金属蛋白酶抑制剂及其应用
CN101538311A (zh) * 2009-04-16 2009-09-23 山东大学 α-氨基酰环酰亚胺类肽金属蛋白酶抑制剂及其应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
宿莉: "脲基类肽氨酶N抑制剂的设计合成及其抗肿瘤活性研究", 《中国博士学位论文全文数据库医药卫生科技辑》 *
李荣坡等: "(S)-5-乙酰胺甲基-3-[(4-取代胺甲基)苯基]-2- 噁唑烷酮衍生物的合成及抗菌活性", 《药学学报》 *
王晓季: "叠氮化合物还原成胺的研究进展", 《化学通报》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108977498A (zh) * 2018-06-19 2018-12-11 潍坊医学院 一种氨肽酶n抑制剂的抑酶活性测定方法及应用
CN108977498B (zh) * 2018-06-19 2022-09-20 潍坊医学院 一种氨肽酶n抑制剂的抑酶活性测定方法及应用

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CN103848778B (zh) 2016-01-06

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