CN103848778A - 一种氨肽酶n抑制剂及其制备方法与应用 - Google Patents
一种氨肽酶n抑制剂及其制备方法与应用 Download PDFInfo
- Publication number
- CN103848778A CN103848778A CN201410123847.9A CN201410123847A CN103848778A CN 103848778 A CN103848778 A CN 103848778A CN 201410123847 A CN201410123847 A CN 201410123847A CN 103848778 A CN103848778 A CN 103848778A
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- CN
- China
- Prior art keywords
- aminopeptidase
- compound
- inhibitor
- cell
- preparation
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/86—Oxygen atoms
- C07D211/88—Oxygen atoms attached in positions 2 and 6, e.g. glutarimide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410123847.9A CN103848778B (zh) | 2014-03-28 | 2014-03-28 | 一种氨肽酶n抑制剂及其制备方法与应用 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410123847.9A CN103848778B (zh) | 2014-03-28 | 2014-03-28 | 一种氨肽酶n抑制剂及其制备方法与应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103848778A true CN103848778A (zh) | 2014-06-11 |
CN103848778B CN103848778B (zh) | 2016-01-06 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201410123847.9A Expired - Fee Related CN103848778B (zh) | 2014-03-28 | 2014-03-28 | 一种氨肽酶n抑制剂及其制备方法与应用 |
Country Status (1)
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CN (1) | CN103848778B (it) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108977498A (zh) * | 2018-06-19 | 2018-12-11 | 潍坊医学院 | 一种氨肽酶n抑制剂的抑酶活性测定方法及应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1974554A (zh) * | 2006-12-12 | 2007-06-06 | 山东大学 | 环酰亚胺类肽金属蛋白酶抑制剂及其应用 |
CN101538311A (zh) * | 2009-04-16 | 2009-09-23 | 山东大学 | α-氨基酰环酰亚胺类肽金属蛋白酶抑制剂及其应用 |
-
2014
- 2014-03-28 CN CN201410123847.9A patent/CN103848778B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1974554A (zh) * | 2006-12-12 | 2007-06-06 | 山东大学 | 环酰亚胺类肽金属蛋白酶抑制剂及其应用 |
CN101538311A (zh) * | 2009-04-16 | 2009-09-23 | 山东大学 | α-氨基酰环酰亚胺类肽金属蛋白酶抑制剂及其应用 |
Non-Patent Citations (3)
Title |
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宿莉: "脲基类肽氨酶N抑制剂的设计合成及其抗肿瘤活性研究", 《中国博士学位论文全文数据库医药卫生科技辑》 * |
李荣坡等: "(S)-5-乙酰胺甲基-3-[(4-取代胺甲基)苯基]-2- 噁唑烷酮衍生物的合成及抗菌活性", 《药学学报》 * |
王晓季: "叠氮化合物还原成胺的研究进展", 《化学通报》 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108977498A (zh) * | 2018-06-19 | 2018-12-11 | 潍坊医学院 | 一种氨肽酶n抑制剂的抑酶活性测定方法及应用 |
CN108977498B (zh) * | 2018-06-19 | 2022-09-20 | 潍坊医学院 | 一种氨肽酶n抑制剂的抑酶活性测定方法及应用 |
Also Published As
Publication number | Publication date |
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CN103848778B (zh) | 2016-01-06 |
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PB01 | Publication | ||
C10 | Entry into substantive examination | ||
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C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20160106 Termination date: 20180328 |
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CF01 | Termination of patent right due to non-payment of annual fee |