CN103012248B - 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用 - Google Patents

氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用 Download PDF

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CN103012248B
CN103012248B CN201310011060.9A CN201310011060A CN103012248B CN 103012248 B CN103012248 B CN 103012248B CN 201310011060 A CN201310011060 A CN 201310011060A CN 103012248 B CN103012248 B CN 103012248B
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cancer
amino
compound
trimethoxyphenyl
ethene
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CN103012248A (zh
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王建平
王建国
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Zhejiang Dade Pharmaceutical Group Co Ltd
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Zhejiang Dade Pharmaceutical Group Co Ltd
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Priority to PCT/CN2014/070286 priority patent/WO2014108066A1/zh
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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CN201310011060.9A 2013-01-11 2013-01-11 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用 Active CN103012248B (zh)

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CN201310011060.9A CN103012248B (zh) 2013-01-11 2013-01-11 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用
PCT/CN2014/070286 WO2014108066A1 (zh) 2013-01-11 2014-01-08 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用

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Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103012248B (zh) * 2013-01-11 2014-11-05 浙江大德药业集团有限公司 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用
CN104447598B (zh) * 2013-09-18 2017-09-22 浙江大德药业集团有限公司 Ca‑4的大环多胺衍生物及其抗肿瘤特性
US9487482B2 (en) * 2014-05-09 2016-11-08 Council Of Scientific And Industrial Research 3,4,5-trimethoxystyrylarylaminopropenones as potential anticancer agents
CN107365248A (zh) * 2017-07-25 2017-11-21 上海应用技术大学 二氟甲氧基取代的二苯乙烷及反式二苯乙烯衍生物及其制备方法和应用
CN112225673B (zh) * 2020-11-13 2022-08-02 义乌市华耀医药科技有限公司 氨基康普立停衍生物及其应用

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US5561122A (en) * 1994-12-22 1996-10-01 Arizona Board Of Regents Acting On Behalf Of Arizona State University Combretastatin A-4 prodrug
CN1465580A (zh) * 2002-06-07 2004-01-07 深圳市北大高科技股份有限公司 一种简便合成康普立停a-4前药的方法
CN101085743A (zh) * 2006-06-06 2007-12-12 浙江大德药业集团有限公司 含氟烷氧基康普立停衍生物及制法和用途

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TW334418B (en) * 1995-03-07 1998-06-21 Ajinomoto Kk Stilbene derivatives and pharmaceutical compositions
FR2838437B1 (fr) * 2002-04-11 2004-06-04 Aventis Pharma Sa Procedes de preparation de combretastatines
CN102249987B (zh) * 2011-05-06 2013-07-24 兰州大学 一种考布他汀类化合物及其制备方法和用途
WO2013084150A1 (en) * 2011-12-06 2013-06-13 Sanofi Novel crystal form of (2s)-2-amino-3-hydroxy-n-[2-methoxy-2-[(1z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl]propanamide and method of preparation thereof
CN103012248B (zh) * 2013-01-11 2014-11-05 浙江大德药业集团有限公司 氨基康普立停衍生物的合成及其作为口服抗肿瘤药物的应用

Patent Citations (4)

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Publication number Priority date Publication date Assignee Title
US5430062A (en) * 1992-05-21 1995-07-04 Research Corporation Technologies, Inc. Stilbene derivatives as anticancer agents
US5561122A (en) * 1994-12-22 1996-10-01 Arizona Board Of Regents Acting On Behalf Of Arizona State University Combretastatin A-4 prodrug
CN1465580A (zh) * 2002-06-07 2004-01-07 深圳市北大高科技股份有限公司 一种简便合成康普立停a-4前药的方法
CN101085743A (zh) * 2006-06-06 2007-12-12 浙江大德药业集团有限公司 含氟烷氧基康普立停衍生物及制法和用途

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