CN102949223A - Shape memory spring coil and manufacture method and application method thereof - Google Patents
Shape memory spring coil and manufacture method and application method thereof Download PDFInfo
- Publication number
- CN102949223A CN102949223A CN2011102494214A CN201110249421A CN102949223A CN 102949223 A CN102949223 A CN 102949223A CN 2011102494214 A CN2011102494214 A CN 2011102494214A CN 201110249421 A CN201110249421 A CN 201110249421A CN 102949223 A CN102949223 A CN 102949223A
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- China
- Prior art keywords
- shape memory
- memory spring
- shape
- spring circle
- spring coil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/12145—Coils or wires having a pre-set deployed three-dimensional shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00867—Material properties shape memory effect
- A61B2017/00871—Material properties shape memory effect polymeric
Abstract
A shape memory spring coil is a spiral structural member made of shape memory polymer material. A manufacture method of the shape memory spring coil includes firstly manufacturing polymer threads by the process of extrusion molding; secondly, manufacturing the thread-type shape memory spring coil by a mold into a spiral shape (permanent shape); and thirdly, fixing the shape of the polymer into a straight fine-thread shape (temporary shape) by a proper method. An application method of the shape memory spring coil includes conveying the straight fine-threaded spring coil to an aneurysm cavity through a micro catheter, the fine-threaded spring coil automatically restores to the original spiral structure at human body temperature, and accordingly aneurysm is packed. The spring coil made of polymer material with biocompatibility compared with metal is small in density, low in rigidity and soft in texture, compact packing rate of the aneurysm cavity can be increased, risk of perforating aneurysm by the spring coil in operation is lowered, damage of peripheral nerves and vessels, which is caused by gravity press after embolism of the spring coil, is reduced, manufacture process is simple, and cost is low.
Description
Technical field
The present invention relates to medical apparatus and instruments, particularly a kind of shape memory spring circle.
Background technology
Aneurysm is the angiomatoid projection that produces owing to arterial vascular abnormal change.In the situations such as the unexpected rising of blood pressure in the blood vessel or arteriosclerosis, it is hemorrhage that aneurysm can be broken, and will cause the patient to be disabled or death.At present, it is that a microtubular is sent in the aneurysm cavity that endovascular neurosurgery is treated aneurysmal method, with material occlude such as turn, medical adhesives, thereby prevents aneurysmal subarachnoid hemorrhage and recurrence, and the patient is fully recovered.The method has the outstanding advantages such as wound is little, misery is little, recover soon, danger is low, success rate is high, by patient is accepted extensively.Part American-European countries with endovascular neurosurgery as the treatment aneurysmal prefered method.For opening aneurysm that cranium is difficult to arrive, being difficult to patient tolerate surgery or hemorrhage acute stage, endovascular treatment can be proved effective equally.
At present, what the application of intravascular internal therapy aneurysm was maximum is the Application of Guglielmi Detachable Coil embolization technique, the used turn of this technology is a kind of tinsel of platinum material, is made into the plurality of specifications such as different-diameter, length and shape, is connected with a metal pushrod.In the thromboembolism operation, a microtubular is inserted in the aneurysm cavity, then with push rod with turn in microtubular pushes aneurysm cavity, utilize the mechanical blocking action of turn and the thrombosis blocking action of secondary, aneurysm is isolated from outside the blood circulation of parent artery, thereby reach the purpose that prevents that aneurysm from breaking again.This technology makes some intracranial aneurysm obtain timely and effectively treatment, but clinical practice is found, this technology also exists some drawbacks inevitably, for example: because treatment behavior occurs in the aneurysm cavity, and used turn is to be made by metal material, the danger that exists art medium-sized artery tumor to break when therefore operating; The densification filling rate in tumor chamber is lower, open rate is higher again for aneurysm; The compressing of gravity easily causes the damage of peripheral nerve and blood vessel behind the giant aneurysm tumor intracavity filling turn.In addition, owing to the reason of platinum material price has caused the surgery cost of this technology very expensive, limited its at home application in market.Therefore, explore a kind of more preferably the treatment with material and become the focus that the interventional therapy scholar pays close attention to always.
Polyurethane is a kind of very promising shape memory polymer material, and its shape memory temperature can be regulated in-30 ℃～70 ℃ scopes as required.Simultaneously, because it has preferably mechanical characteristic and biocompatibility, therefore also can be used for the making that body is implanted into medical apparatus and instruments.At present, not yet see the report of making the endovascular aneurysm turn of shape memory polymer material.
Summary of the invention
Purpose of the present invention, the problems referred to above that exist in order to solve prior art exactly provide a kind of shape memory spring circle and preparation method thereof and using method.
To achieve these goals, the present invention has adopted following technical scheme: a kind of shape memory spring circle is the helicoidal structure spare that is made by shape memory polymer material.
Described shape memory spring circle surface can apply or not apply the medicine that can efficiently form effect of embolization.
Described shape memory polymer material is that polyurethane or other have the shape-memory polymer of better biocompatibility.
The manufacture method of above-mentioned shape memory spring circle may further comprise the steps:
A, take glass transition temperature be the shape memory recovery temperature as 37.5 ℃ shape memory polymer material as raw material, utilize extruding-out process to be made into filament;
B, mould with helical form die cavity of making place step a gained filament in the mould, with the temperature a little less than the shape memory polymer material fusing point mould are heated, and are incubated 1 hour;
C, with mold cools down to room temperature, make helical rib memory spring circle after the demoulding;
D, under the condition of 15 ℃ of the glass transition temperatures that is higher than shape memory polymer material, stretching and two ends are fixed with step c gained helical rib memory spring circle, be incubated 3 minutes, then be cooled to room temperature, then this helical rib memory spring circle remains raw silk rings shape shape memory spring circle;
E, with after the steps d gained raw silk rings shape shape memory spring circle sterilization, the vacuum drying sealing is for subsequent use.
The using method of above-mentioned shape memory spring circle may further comprise the steps:
One, guiding catheter is sent to patient's arterial disease place, in advance the parent artery radiography;
Two, the microtubular head end is inserted in the aneurysm cavity under the micro-wire guiding through guiding catheter;
Three, through microtubular raw silk rings shape shape memory spring circle is sent to the tumor intracavity, under body temperature, raw silk rings shape shape memory spring circle will revert to initial helical rib memory spring circle automatically;
Four, select the turn of different size according to tumor chamber size, with the fine and close filling of aneurysm;
Five, withdraw from conduit system.
Shape memory spring circle of the present invention owing to adopted above technical scheme, makes it compared with prior art, has following advantage and beneficial effect:
1, compare with the platinum material, the rigidity of shape memory polymer material is lower, and quality is soft, can improve the densification filling rate in tumor chamber, increases the thromboembolism density in the aneurysm, thereby can reduce aneurysmal more open rate.
2, because turn is to make of the shape memory polymer material of quality softness, therefore can reduces the art spring coil of being hit by a bullet and wear out aneurysmal risk.
3, the density ratio platinum material of shape memory polymer material is low about 20 times, and is therefore lighter by the turn weight of its making, can reduce behind the Coil embolization because the compressing of gravity causes the damage to peripheral nerve and blood vessel.
4, turn of the present invention adopts polymeric material, and for the platinum material, its processing technology is simple, and is with low cost, but decrease patient's medical treatment burden.
Description of drawings
Fig. 1 is the shape of the shape memory spring circle of one embodiment of the invention;
Fig. 2 is that the shape memory spring circle is stretching and the shape of two ends after fixing;
Fig. 3 is that the microtubular head end is inserted the shape in the aneurysm cavity;
Fig. 4 is that the shape memory spring circle is through microtubular filling aneurysm sketch map;
Fig. 5 is that the shape memory spring circle fills up the aneurysm sketch map fully.
The specific embodiment
The present invention is described in detail below in conjunction with the drawings and specific embodiments.
Shape memory spring circle of the present invention is the helicoidal structure spare that is made by shape memory polymer material as shown in Figure 1.Shape memory polymer material wherein is that polyurethane or other have the shape-memory polymer of better biocompatibility.
The manufacture method of shape memory spring circle of the present invention and using method can be described as follows by following embodiment:
Utilizing extruding-out process, is that 37.5 ℃ polyurethane particles is made into filament with glass transition temperature (being the shape memory recovery temperature).
Make the mould with helical form die cavity, filament is placed in the mould, with the temperature a little less than the polyurethane fusing point mould is heated, and be incubated 1 hour, the demoulding makes helical rib memory spring circle 1 after the cooling, as shown in Figure 1.
Under the condition that is higher than 15 ℃ of polyurethane glass transition temperatures, with clip 2 helical rib memory spring circle is fixed stretching and two ends, be incubated 3 minutes, then be cooled to room temperature, then this helical rib memory spring circle remains raw silk rings shape shape memory spring circle, as shown in Figure 2.
After the sterilization of raw silk rings shape shape memory spring circle, the vacuum drying sealing is for subsequent use.
In use, by arteries 3 head end of microtubular 4 is inserted in the aneurysm cavity 5, as shown in Figure 3 under the micro-wire guiding through guiding catheter.
Raw silk rings shape shape memory spring circle 1 is put into aneurysm cavity 5 via microtubular 4.When raw silk rings shape shape memory spring circle 1 extend in the aneurysm cavity from microtubular 4 successively, it can revert to helical rib memory spring circle automatically by shape memory function, and then filling aneurysm cavity 5, as shown in Figure 4.
According to the size in tumor chamber, can place one or more shape memory spring circles, until till shape memory spring circle 1 fills up aneurysm cavity 5, as shown in Figure 5.
Above-described embodiment is preferably embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other is any not to deviate from change, the modification done under spirit of the present invention and the principle, substitute; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (5)
1. a shape memory spring circle is characterized in that: be the helicoidal structure spare that is made by shape memory polymer material.
2. shape memory spring circle as claimed in claim 1, it is characterized in that: described shape memory spring circle surface can apply or not apply the medicine that can efficiently form effect of embolization.
3. shape memory spring circle as claimed in claim 1 is characterized in that: described shape memory polymer material is that polyurethane or other have the shape-memory polymer of better biocompatibility.
4. the manufacture method of shape memory spring circle as claimed in claim 1 is characterized in that, may further comprise the steps:
A, take glass transition temperature be the shape memory recovery temperature as 37.5 ℃ shape memory polymer material as raw material, utilize extruding-out process to be made into filament;
B, mould with helical form die cavity of making place step a gained filament in the mould, with the temperature a little less than the shape memory polymer material fusing point mould are heated, and are incubated 1 hour;
C, with mold cools down to room temperature, make helical rib memory spring circle after the demoulding;
D, under the condition of 15 ℃ of the glass transition temperatures that is higher than shape memory polymer material, stretching and two ends are fixed with step c gained helical rib memory spring circle, be incubated 3 minutes, then be cooled to room temperature, then this helical rib memory spring circle remains raw silk rings shape shape memory spring circle;
E, with after the steps d gained raw silk rings shape shape memory spring circle sterilization, the vacuum drying sealing is for subsequent use.
5. the using method of shape memory spring circle as claimed in claim 1 is characterized in that, may further comprise the steps:
One, guiding catheter is sent to patient's arterial disease place, in advance the parent artery radiography;
Two, the microtubular head end is inserted in the aneurysm cavity under the micro-wire guiding through guiding catheter;
Three, through microtubular raw silk rings shape shape memory spring circle is sent to the tumor intracavity, under body temperature, raw silk rings shape shape memory spring circle will revert to initial helical rib memory spring circle automatically;
Four, select the turn of different size according to tumor chamber size, with the fine and close filling of aneurysm;
Five, withdraw from conduit system.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102494214A CN102949223A (en) | 2011-08-26 | 2011-08-26 | Shape memory spring coil and manufacture method and application method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011102494214A CN102949223A (en) | 2011-08-26 | 2011-08-26 | Shape memory spring coil and manufacture method and application method thereof |
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| Publication Number | Publication Date |
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| CN102949223A true CN102949223A (en) | 2013-03-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011102494214A Pending CN102949223A (en) | 2011-08-26 | 2011-08-26 | Shape memory spring coil and manufacture method and application method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105879192A (en) * | 2016-07-07 | 2016-08-24 | 许岗勤 | Aneurysm embolization micro-catheter |
Citations (6)
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|---|---|---|---|---|
| WO1996018343A1 (en) * | 1994-12-13 | 1996-06-20 | Micro Interventional Systems, Inc. | Embolic elements and methods and apparatus for their delivery |
| US6024754A (en) * | 1996-01-18 | 2000-02-15 | Target Therapeutics Inc. | Aneurysm closure method |
| WO2004010901A1 (en) * | 2002-07-26 | 2004-02-05 | Sdgi Holdings, Inc. | Axially expanding polymer stent |
| CN1894313A (en) * | 2003-12-12 | 2007-01-10 | 日本电气株式会社 | Reshapable shape-memory resin excelling in shape recovery capability and shaped item of the resin having been crosslinked |
| US20090227976A1 (en) * | 2008-03-05 | 2009-09-10 | Calabria Marie F | Multiple biocompatible polymeric strand aneurysm embolization system and method |
| JP4752339B2 (en) * | 2005-06-10 | 2011-08-17 | 日本電気株式会社 | Shape memory resin having excellent shape recovery ability in two stages and molded article comprising cross-linked product of the resin |
-
2011
- 2011-08-26 CN CN2011102494214A patent/CN102949223A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996018343A1 (en) * | 1994-12-13 | 1996-06-20 | Micro Interventional Systems, Inc. | Embolic elements and methods and apparatus for their delivery |
| US6024754A (en) * | 1996-01-18 | 2000-02-15 | Target Therapeutics Inc. | Aneurysm closure method |
| WO2004010901A1 (en) * | 2002-07-26 | 2004-02-05 | Sdgi Holdings, Inc. | Axially expanding polymer stent |
| CN1894313A (en) * | 2003-12-12 | 2007-01-10 | 日本电气株式会社 | Reshapable shape-memory resin excelling in shape recovery capability and shaped item of the resin having been crosslinked |
| JP4752339B2 (en) * | 2005-06-10 | 2011-08-17 | 日本電気株式会社 | Shape memory resin having excellent shape recovery ability in two stages and molded article comprising cross-linked product of the resin |
| US20090227976A1 (en) * | 2008-03-05 | 2009-09-10 | Calabria Marie F | Multiple biocompatible polymeric strand aneurysm embolization system and method |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105879192A (en) * | 2016-07-07 | 2016-08-24 | 许岗勤 | Aneurysm embolization micro-catheter |
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Application publication date: 20130306 |