CN102764168A - Elastic shape memory recyclable bracket and manufacturing method and using method thereof - Google Patents
Elastic shape memory recyclable bracket and manufacturing method and using method thereof Download PDFInfo
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- CN102764168A CN102764168A CN2011101132894A CN201110113289A CN102764168A CN 102764168 A CN102764168 A CN 102764168A CN 2011101132894 A CN2011101132894 A CN 2011101132894A CN 201110113289 A CN201110113289 A CN 201110113289A CN 102764168 A CN102764168 A CN 102764168A
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- shape memory
- elastic shape
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- bracket
- elastic
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Abstract
The invention relates to an elastic shape memory recyclable bracket, which is a tubular structural element manufactured by 80-100 parts of elastic shape memory polymer material and 0-20 parts of biocompatible micro powder (part by weight); a manufacturing method comprises the following steps: manufacturing raw materials as a folding-shaped bracket by a mould and expanding the folding-shaped bracket to form a tubular bracket through a ball expansion method; a using method comprises the following steps: compressing the tubular bracket in a catheter so as to transport to an internal lesion part; removing the catheter so that a bracket is restored into a tube shape; heating the tubular bracket to a shape memory restring temperature at withdrawing time; and restoring the bracket from the tube shape into an initial folding shape, thus, withdrawing the bracket conveniently. According to the invention, the manufacturing material of the bracket is polymer material with biocompatibility and/or biodegradability and has little stimulation for tissues; relatively to a metal bracket, the elastic shape memory recyclable bracket is characterized by simple manufacturing technology and low cost; in addition, therapeutic medicines are coated on the surface of the bracket so as to further enhance therapeutic effect.
Description
Technical field
The present invention relates to medical apparatus and instruments, particularly a kind of elastic shape memory recoverable support and preparation method thereof and method for using.
Background technology
In lysises such as treatment air flue organic stenosis, esophageal carcinoma, bladder/carcinoma of prostate, the vivo implantation type stent applications is extensive.The implantation of many clinically situation lower carriages is temporary, and along with the treatment of primary lesion, alleviating of narrow positions chocking-up degree needs to reclaim support.
Existing vivo implantation type support mainly is that these supports have all utilized the super-elasticity of timbering material or supporting structure basically with material such as rustless steel, NiTi alloys, and support itself can self-expanding, but can not self-constriction.The process that support is implanted is earlier it to be compressed in the conduit basically, is transported to diseased region in the body, and after removing conduit and discharging support, support begins to expand.In order to prevent the support phenomenon that is moved, support must have enough rigidity, makes it discharge that the back closely contacts with surrounding tissue and not yielding.Yet result of design is like this, in many disease treatment processes that only need interim implant frame (for example, the microtubular of optimum stenosis of colon is got involved and treatment), is difficult to support is taken out after treatment is accomplished, and promptly support reclaims difficulty.This has become existing common defective of implanted support.Therefore, limited the clinical practice of vivo implantation type support to a certain extent.The body interior conduit that particularly causes for benign lesion narrow uses to be restricted more.
In addition, no matter present employed vivo implantation type support is metal rack or polymer support, and major part all is a braiding structure, in tissue, aspect the growth higher incidence is arranged.
Polyurethane is a kind of very promising shape memory polymer material, and its shape memory temperature can be regulated in-30 ℃～70 ℃ scopes as required.Because it has mechanical characteristic and biocompatibility preferably, therefore also can be used for the making that body is implanted into medical apparatus and instruments simultaneously.At present, do not see the report of making recoverable support in the body with shape memory polymer material as yet.
Summary of the invention
The object of the invention in order to solve the problems referred to above that prior art exists, provides a kind of elastic shape memory recoverable support and preparation method thereof and method for using exactly.
To achieve these goals; The present invention has adopted following technical scheme: a kind of elastic shape memory recoverable support is the tubular structural member that the biocompatibility micropowder by the elastic shape memory polymer material of 80-100 weight portion and 0-20 weight portion is made.
Described recoverable support surface can apply or not apply curative drug.
Described elastic shape memory polymer material is that polyurethane or other have the elastic shape memory polymer of better biocompatibility; Described micropowder is Fe
3O
4Micropowder or other have the micropowder of biocompatibility.
The manufacture method of above-mentioned elastic shape memory recoverable support may further comprise the steps:
The said biocompatibility micropowder mix homogeneously of a, the said elastic shape memory polymer material of getting the 80-100 weight portion and 0-20 weight portion is as raw material; Wherein, the glass transition temperature of elastic shape memory polymer material is that the shape memory recovery temperature is between 38 ℃-40 ℃;
B, make the mould with star or other collapsed shape, step a gained raw material is placed in the mould, extrusion forming under the temperature that is higher than the elastic shape memory polymer material melting point makes the support of star or other collapsed shape after the demoulding;
C, with step b gained support under the condition of 15 ℃ of the glass transition temperatures that is higher than the elastic shape memory polymer material, the mode through inflation is expanded to tubulose, is cooled to room temperature then, promptly obtains tubulose elastic shape memory recoverable support product;
D, with after the elastic shape memory recoverable support effect product sterilization, obtain elastic shape memory recoverable support finished product, vacuum drying sealing is subsequent use.
The method for using of above-mentioned elastic shape memory recoverable support may further comprise the steps:
One, the elastic shape memory recoverable support is compressed in the conduit, is transported to diseased region in the body;
Two, remove conduit, then the elastic shape memory recoverable support reverts to tubulose at diseased region through elastic deformation, and diseased region is strutted;
When three, needing to take out the elastic shape memory recoverable support; The elastic shape memory recoverable support is heated to its shape memory recovery temperature; Then the elastic shape memory recoverable support is through SME, and contraction reverts to star or other predefined collapsed shape;
Four, the support after taking-up is shunk.
The elastic shape memory recoverable support being heated to its shape memory recovery temperature described in the step 3, is through the saline after the sterilization it to be heated.
The elastic shape memory recoverable support is heated to its shape memory recovery temperature described in the step 3; When the elastic shape memory recoverable support is made by the mixture of elastic shape memory polymer material and biocompatibility magnetic powder; Can utilize magnetic induction that it is heated through in the external oscillating magnetic field that applies of patient.
Elastic shape memory recoverable support of the present invention owing to adopted above technical scheme, makes it compared with prior art, has following advantage and beneficial effect:
1, elastic shape memory recoverable support of the present invention, its manufacturing materials has biocompatibility and/or biological degradability, and is little to tissue stimulation.
2, after support implants, when disease alleviates or treats the taking-up of end needs, can realize the automatic contraction of support, its volume reduced, thereby be convenient in body, take out through suitable environmental stimuli.
3, recoverable support overall structure of the present invention is a tubulose, has avoided ordinary stent to adopt braiding structure to cause organizing the defective of interior growth.
4, through at the stent surface coated curative drug, further intensive treatment effect also.
5, recoverable support of the present invention adopts polymeric material, and for metal rack, its processing technology is simple, and is with low cost, can reduce patient's medical treatment burden significantly.
Description of drawings
Fig. 1 is the star-shaped support shape of one embodiment of the invention;
Fig. 2 puts into the shape behind the star-shaped support with the sacculus of unaerated;
Fig. 3 makes star-shaped support be expanded to tubulose through the inflation mode;
Fig. 4 is the shape after star-shaped support expands, the shape of elastic shape memory recoverable support promptly of the present invention;
Fig. 5 is the state after support implants;
Fig. 6 is after being heated to shape memory temperature, and the elastic shape memory recoverable support reverts to the star-shaped support original state.
The specific embodiment
Below in conjunction with accompanying drawing and specific embodiment the present invention is elaborated.
Elastic shape memory recoverable support of the present invention is as shown in Figure 4, is the tubular structural member that the biocompatibility micropowder by the elastic shape memory polymer material of 80-100 weight portion and 0-20 weight portion is made.Can apply curative drug on the recoverable support surface or not apply curative drug.Elastic shape memory polymer material wherein is that polyurethane or other have the elastic shape memory polymer of better biocompatibility; Micropowder is Fe
3O
4Micropowder or other have the micropowder of biocompatibility.
The manufacture method of elastic shape memory recoverable support of the present invention and method for using can specify through following embodiment as follows:
Processing a star mould, is that 39 ℃ polyurethane particles is put into mould with glass transition temperature (being the shape memory recovery temperature), is being higher than extrusion forming under the temperature of its fusing point, makes star-shaped support 1 after the demoulding, as shown in Figure 1.
Under the temperature that is higher than 15 ℃ of its glass transition temperatures, make star-shaped support 1 be expanded to tubular bracket 1 through sacculus 2 expansible modes, like Fig. 2 and shown in Figure 3.Be cooled to room temperature then, then support will remain tubulose, and will be as shown in Figure 4.
After the tubular bracket sterilization, the vacuum drying sealing is subsequent use.
Utilize the elasticity of polyurethane that tubular bracket is compressed in the conduit in use, be transported to diseased region 3 in the body, remove conduit, then this support 1 will strut with piped form at diseased region through elastically-deformable recovery, and will be as shown in Figure 5.
After patient's disease alleviates or treats end, when needing to take out tubular bracket, utilize the saline after sterilizing that it is heated.When temperature reaches 39 ℃ (being the shape memory recovery temperature), this tubular bracket will revert to initial star-shaped support 1 through SME, and will be as shown in Figure 6, owing to volume reduces, so be convenient to take out.
Process a star mould.
With magnetic Fe
3O
4It is in 39 ℃ the polyurethane solutions that micropowder evenly is blended into glass transition temperature (being the shape memory recovery temperature) through sonic oscillation, Fe
3O
4The percentage by weight of micropowder and polyurethane is 5: 95.
Above-mentioned mixed liquor is poured in the mould, be heated to 80 ℃ and make its curing molding, make after the demoulding and contain Fe
3O
4The star-shaped support of micropowder.
Under the temperature that is higher than 15 ℃ of polyurethane glass transition temperatures, the mode through inflation makes and contains Fe
3O
4The star-shaped support of micropowder is expanded to tubulose, is cooled to room temperature then, and then support will remain tubulose.
To contain Fe
3O
4After the tubular bracket sterilization of micropowder, the vacuum drying sealing is subsequent use.
Utilize the elasticity of polyurethane will contain Fe in use
3O
4The tubular bracket of micropowder is compressed in the conduit, is transported to diseased region in the body, removes conduit, and then this support will strut with piped form at diseased region through elastically-deformable recovery.
After patient's disease alleviates or treats end, need to take out and contain Fe
3O
4During the support of micropowder, can utilize magnetic induction that it is heated in the external oscillating magnetic field that applies of patient.When temperature reaches 39 ℃ (being the shape memory recovery temperature), this tubular bracket will return to its initial star through SME, owing to volume reduces, so be convenient to take out.
The foregoing description is the present invention's embodiment preferably; But embodiment of the present invention is not restricted to the described embodiments; Other is any not to deviate from change, the modification done under spirit of the present invention and the principle, substitute, combination, simplify; All should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (7)
1. elastic shape memory recoverable support is characterized in that: be the tubular structural member that the biocompatibility micropowder by the elastic shape memory polymer material of 80-100 weight portion and 0-20 weight portion is made.
2. elastic shape memory recoverable support as claimed in claim 1 is characterized in that: described recoverable support surface can apply or not apply curative drug.
3. elastic shape memory recoverable support as claimed in claim 1 is characterized in that: described elastic shape memory polymer material is that polyurethane or other have the elastic shape memory polymer of better biocompatibility; Described micropowder is Fe
3O
4Micropowder or other have the micropowder of biocompatibility.
4. the manufacture method of elastic shape memory recoverable support as claimed in claim 1 is characterized in that, may further comprise the steps:
The said biocompatibility micropowder mix homogeneously of a, the said elastic shape memory polymer material of getting the 80-100 weight portion and 0-20 weight portion is as raw material; Wherein, the glass transition temperature of elastic shape memory polymer material is that the shape memory recovery temperature is between 38 ℃-40 ℃;
B, make the mould with star or other collapsed shape, step a gained raw material is placed in the mould, extrusion forming under the temperature that is higher than the elastic shape memory polymer material melting point makes the support of star or other collapsed shape after the demoulding;
C, with step b gained support under the condition of 15 ℃ of the glass transition temperatures that is higher than the elastic shape memory polymer material, the mode through inflation is expanded to tubulose, is cooled to room temperature then, promptly obtains tubulose elastic shape memory recoverable support product;
D, with after the elastic shape memory recoverable support effect product sterilization, obtain elastic shape memory recoverable support finished product, vacuum drying sealing is subsequent use.
5. the method for using of elastic shape memory recoverable support as claimed in claim 1 is characterized in that, may further comprise the steps:
One, the elastic shape memory recoverable support is compressed in the conduit, is transported to diseased region in the body;
Two, remove conduit, then the elastic shape memory recoverable support reverts to tubulose at diseased region through elastic deformation, and diseased region is strutted;
When three, needing to take out the elastic shape memory recoverable support; The elastic shape memory recoverable support is heated to its shape memory recovery temperature; Then the elastic shape memory recoverable support is through SME, and contraction reverts to star or other predefined collapsed shape;
Four, the support after taking-up is shunk.
6. the method for using of elastic shape memory recoverable support as claimed in claim 5 is characterized in that: the elastic shape memory recoverable support being heated to its shape memory recovery temperature described in the step 3, is through the saline after the sterilization it to be heated.
7. the method for using of elastic shape memory recoverable support as claimed in claim 5; It is characterized in that: the elastic shape memory recoverable support is heated to its shape memory recovery temperature described in the step 3; When the elastic shape memory recoverable support is made by the mixture of elastic shape memory polymer material and biocompatibility magnetic powder; Can utilize magnetic induction that it is heated through in the external oscillating magnetic field that applies of patient.
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| CN2011101132894A CN102764168A (en) | 2011-05-03 | 2011-05-03 | Elastic shape memory recyclable bracket and manufacturing method and using method thereof |
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| CN2011101132894A CN102764168A (en) | 2011-05-03 | 2011-05-03 | Elastic shape memory recyclable bracket and manufacturing method and using method thereof |
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Cited By (8)
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| CN105944144A (en) * | 2016-04-29 | 2016-09-21 | 哈尔滨工业大学 | Bone tissue repair material based on shape memory composite material as well as preparation method and application method of bone tissue repair structure |
| CN106473848A (en) * | 2015-08-31 | 2017-03-08 | 上海圣博艾医疗科技有限公司 | Prostate bracket |
| CN106901880A (en) * | 2017-02-04 | 2017-06-30 | 同济大学 | Expand preparation and the application process of formula self expandable developable degradable polyurethane urethra rack in two ends |
| CN107811727A (en) * | 2017-09-29 | 2018-03-20 | 云南靖创液态金属热控技术研发有限公司 | A kind of recyclable cardiac stent |
| CN109745160A (en) * | 2019-03-22 | 2019-05-14 | 福州京东方光电科技有限公司 | A kind of vessel expanding device |
| CN111035810A (en) * | 2019-12-05 | 2020-04-21 | 深圳先进技术研究院 | Multichannel nerve conduit and preparation method thereof |
| CN113995892A (en) * | 2021-11-09 | 2022-02-01 | 上海理工大学 | Rubber-like shape memory recyclable esophageal stent and preparation method thereof |
| CN116672164A (en) * | 2022-02-23 | 2023-09-01 | 柏为（武汉）医疗科技股份有限公司 | Eustachian tube bracket |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106473848A (en) * | 2015-08-31 | 2017-03-08 | 上海圣博艾医疗科技有限公司 | Prostate bracket |
| CN105944144A (en) * | 2016-04-29 | 2016-09-21 | 哈尔滨工业大学 | Bone tissue repair material based on shape memory composite material as well as preparation method and application method of bone tissue repair structure |
| CN106901880A (en) * | 2017-02-04 | 2017-06-30 | 同济大学 | Expand preparation and the application process of formula self expandable developable degradable polyurethane urethra rack in two ends |
| CN107811727A (en) * | 2017-09-29 | 2018-03-20 | 云南靖创液态金属热控技术研发有限公司 | A kind of recyclable cardiac stent |
| CN107811727B (en) * | 2017-09-29 | 2020-05-01 | 云南靖创液态金属热控技术研发有限公司 | Recyclable heart support |
| CN109745160A (en) * | 2019-03-22 | 2019-05-14 | 福州京东方光电科技有限公司 | A kind of vessel expanding device |
| CN111035810A (en) * | 2019-12-05 | 2020-04-21 | 深圳先进技术研究院 | Multichannel nerve conduit and preparation method thereof |
| CN111035810B (en) * | 2019-12-05 | 2022-04-22 | 深圳先进技术研究院 | Multichannel nerve conduit and preparation method thereof |
| CN113995892A (en) * | 2021-11-09 | 2022-02-01 | 上海理工大学 | Rubber-like shape memory recyclable esophageal stent and preparation method thereof |
| CN116672164A (en) * | 2022-02-23 | 2023-09-01 | 柏为（武汉）医疗科技股份有限公司 | Eustachian tube bracket |
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Application publication date: 20121107 |