CN102058927A - Hardness-controlled intelligent conduit for clinical intervention treatment - Google Patents
Hardness-controlled intelligent conduit for clinical intervention treatment Download PDFInfo
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- CN102058927A CN102058927A CN 201010528685 CN201010528685A CN102058927A CN 102058927 A CN102058927 A CN 102058927A CN 201010528685 CN201010528685 CN 201010528685 CN 201010528685 A CN201010528685 A CN 201010528685A CN 102058927 A CN102058927 A CN 102058927A
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Abstract
The invention discloses a hardness-controlled intelligent conduit for clinical intervention treatment. The conduit comprises an external conduit (1) and an internal conduit (3); a main body has the conventional conduit structure; and a metal enhancement layer (2) is arranged on an outer wall of the internal conduit (3); a structure containing a temperature sensitive high polymer layer also can be adopted, and a metal resistive layer (5) is arranged on the outer wall of the internal conduit (3); and a temperature sensitive high polymer layer (4) is coated on the external conduit (1). By applying a voltage or current signal on the metal enhancement layer (2) or the metal resistive layer (5), a local thermal effect is generated, the temperature of the temperature sensitive high polymer layer is raised, and Young modulus (also called hardness) is reduced. After an electric signal is cut off, the temperature of the polymer layer can be continuously reduced, while the hardness of the conduit is gradually increased to reach the initial hardness. The hardness-controlled intelligent conduit can greatly reduce the cost of frequently replacing the conduit, reduces the difficulty and risk of an operation, and shortens the operation time.
Description
Technical field
The present invention relates to a kind of intelligent duct, be specifically related to a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy.
Technical background
Interventional therapy is the emerging in the world in the last few years a kind of invasive Therapeutic Method that utilizes modern high tech method to carry out that grows up.It is under the guidance of medical imaging device (digital X-ray machine, CT machine, nuclear magnetic resonance machine), and accurate apparatus such as special conduit, seal wire is introduced patient body, and diseased region in the body is diagnosed and topical therapeutic.Compare with the Drug therapy of traditional internal medicine and the operative treatment of surgery, interventional therapy have do not operate on, wound is little, recovery is fast, characteristics such as effective, can treat many can't the treatment in the past or disease that other means therapeutic effect is not good enough.Perfect day by day along with its technology, interventional therapy now can arrive the nearly all vessel branch of human body and other luminal structure (digestive tract, biliary tract, trachea, nasal tube etc.), and some specific part, become topmost treatment meanss such as many major diseases such as hepatocarcinoma, pulmonary carcinoma, aneurysm, acute coronary, hysteromyoma, with department of medicine and surgery and be called clinical 3 big diagnosis and treatment technology.
Conduit is the main apparatus of interventional therapy, has played the part of very important role in interventional therapy.Selecting suitable conduit is one of the precondition of intervene operation success and key technology.According to purposes, conduit can be divided into guiding catheter, angiography catheter, drug delivery catheter, speckle turnery conduit and dilating catheter etc.The conduit of different functions generally all has different hardness (having different rigidity or pliability in other words).Even if use the conduit of specific function, doctors also often need according to the difference of intervener's body region and the difference between the individual patients, repeatedly change conduit with carrying out smoothly of guaranteeing to perform the operation in operation process.With the used guiding catheter of coronary heart disease interventional therapy is example, and conduit at first enters human body from femoral artery or radial artery, sends into the coronary artery pathological changes place along arteries and fixes.This crosses that the range request guiding catheter has good pliability so that it can be advanced along cranky blood vessel and not damage the vascular wall of approach., when inserting the support of dribbling capsule, its internal cavities then requires guiding catheter to have usually to advance with the opposing support to impose on the pressure of conduit in the process in the fixing back of catheter position than higher hardness.Yet the conduit of having developed in the market all can not satisfy these requirements simultaneously.For solving this difficult problem, the compromise way that present stage adopts clinically is the conduit of a series of different hardness of preparation, inserts the low conduit of hardness earlier, and then the hardness of replacing successively until conduit with the higher conduit of hardness reaches target call.Though this way has solved the introducing conduit and introduced in the support process conduit hardness is required unmatched contradiction, also caused new problem: the one, prolonged the time of interventional therapy operation greatly.According to statistics, extremely finally fixedly the used time of conduit of ideal grade accounts for 1/3rd of whole interventional therapy total time from first insertion flexible catheter.Because the introducing of conduit and fixedly need radioactivity medical imaging device assist location prolongs this process and means that the increase patient is exposed to the time of radioactive ray; The 2nd, repeatedly replace the cost that conduit has improved treatment, strengthen the probability that punctures vascular wall, thereby increased the risk and the difficulty of operation.
Along with updating of Other related equipment in the interventional therapy and technology, the contradiction that unitary catheter hardness can not be regulated and control seems particularly outstanding now.How to address this problem has fully and effectively become the inevitable requirement of further improving interventional therapeutic technique.Unfortunately, owing to lack clear and definite thinking, the research to it still is in the primary stage in worldwide at present.Great majority work mainly concentrates on carries out machine rebuilding to the catheter interior structure, and as existing monolayer composite conduit wall being divided into independently two layers or multilayer, layers of material has different hardness, utilizes the space between each layer to regulate its overall hardness.Yet even if use so complicated guide-tube structure, the regulatable scope of conduit hardness is still limited, can not satisfy actual demand clinically.
Summary of the invention
Technical problem to be solved by this invention provides a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy, to substitute the single hardness conduit that adopts in the existing clinical interventional therapy, effectively solve in the intervene operation and must frequently change conduit to adapt to the difficult problem of different hardness requirement.
The present invention realizes by following technical solution:
A kind of adjustable hardness intelligent duct that is used for clinical interventional therapy, described conduit comprises outer catheter and interior pipe, it is characterized in that being coated with on the outer catheter responsive to temperature high polymer layer.
Above-mentioned a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy, described responsive to temperature high molecular polymerization layer and outer tube, the compound extrusion way of interior pipe.
Above-mentioned a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy, described outer catheter material is block polyurethane, nylon, polyethylene or polrvinyl chloride, inner tube material is politef or block polyurethane; Described outer wall of inner tube has metal enhancement layer or metallic resistance layer.
Above-mentioned a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy, described responsive to temperature high polymer layer is coated in the outer wall of outer catheter.
Above-mentioned a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy, described responsive to temperature high molecular polymer has biocompatibility, and glass transition temperature or fusing point are near blood heat's scope.
Above-mentioned a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy, described responsive to temperature high molecular polymerization layer are one or more of paraffin, polycaprolactone, polyurethane, polyvinyl acetate.
Above-mentioned a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy, described responsive to temperature high molecular polymerization layer are the complex of one or more and inorganic nano-particle of paraffin, polycaprolactone, polyurethane, polyvinyl acetate.
Above-mentioned a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy, described metallic resistance layer adopt plating, chemical plating or magnetron sputtering mode to be plated on the outer wall of inner tube.
Described external tube layer material is generally block polyurethane, nylon, polyethylene and polrvinyl chloride; Interior pipe layer material generally is politef or block polyurethane.
Than single hardness conduit commonly used at present, the present invention has the following advantages:
(1) a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy of the present invention can be in the patient narrow temperature range of human body the hardness at modulation distal end of catheter or any position, thoroughly solve the conduit hardness that often runs in the interventional therapy difficult problem that do not match.
(2) a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy of the present invention helps in vivo fixing of conduit at stimulate the signal of telecommunication to disappear shape memory function that the back presented, avoid breaking away from the phenomenon of diseased region because of the conduit that the subsequent procedures operation causes, greatly reduce the difficulty and the risk of operation, shortened the time of operation.
(3) compare the production technology that has conduit now, the present invention only needs to make suitable change in technological process, promptly can be used for the production of intelligent duct at the outer application temperature sensitive high molecular weight of inner catheter polymeric layer, and fund input is little, and effect is very obvious, has wide commercial application prospect.
Description of drawings
Fig. 1 is a kind of agent structure sketch map of adjustable hardness intelligent duct.
Fig. 2 is the another kind of agent structure sketch map of adjustable hardness intelligent duct.
Fig. 3 is the The performance test results figure of adjustable hardness intelligent duct in the embodiment.
The specific embodiment
With paraffin be below example the invention will be further described in conjunction with the accompanying drawings and embodiments, but be not limited to this.
The intelligent duct agent structure can adopt existing guide-tube structure, is to apply one deck responsive to temperature high polymer layer 4 at existing guide-tube structure outer catheter 1 outer wall, and metal enhancement layer 2 is arranged on the outer wall of inner tube; Also can adopt to contain responsive to temperature high polymer layer structure, metallic resistance layer 5 is arranged on the outer wall of inner tube.By applying voltage or current signal for metal enhancement layer 2 or metallic resistance layer 5 on the existing conduit outer wall of inner tube, produce local heat effect, improve the temperature of responsive to temperature high polymer layer, reduce its Young's modulus (also being hardness).If cut off the signal of telecommunication this moment, the temperature of polymeric layer can continue to reduce, and the hardness of conduit then can progressively raise until initial hardness.The metallic resistance layer can adopt modes such as plating, chemical plating or magnetron sputtering to be plated on the outer wall of inner tube, but the spin coating of responsive to temperature high molecular polymerization layer is coated on outer catheter or with outer tube, interior pipe is compound extrudes.Under the certain prerequisite of metal enhancement layer or metallic resistance layer resistance, each hardness number in the firmness change interval all corresponding specific magnitude of voltage or current value, in other words, the hardness of intelligent duct can accurately be controlled by the mode of regulation voltage or electric current.If responsive to temperature high polymer layer thickness is certain, the big I that then reaches same rigidity required voltage or electric current is changed by the resistance of metal enhancement layer or extra metallic resistance layer.
The responsive to temperature high polymer layer not only can be positioned at the intelligent duct far-end, also can be distributed in whole conduit or wherein any part, and the intelligent duct far-end adopts 4 layers of structure that contain the responsive to temperature high molecular polymer.Its mechanism of action can illustrate by way of example, as modify the far-end of guiding catheter with the responsive to temperature high polymer layer, in this guiding catheter introducing human vas process, apply the signal of telecommunication and can reduce its most advanced and sophisticated hardness rapidly, help conduit along blood vessel cranky and that have a branched structure advance and do not stab by way of vascular wall, diseased region the to be arrived de-electrifying signal of dropping back, conduit hardness can be recovered again again, and this moment, the shape of catheter tip can be consistent with the shape of peripheral vessels, promptly has certain shape memory function, make it in follow-up operating process, (change seal wire, injectable drug or insert support etc.) can not break away from both allocations, greatly reduce the difficulty and the risk of operation, shortened the time of operation.
The prepared in laboratory of intelligent duct
(intracavity diameter is 1.14mm with the thick polyimide tube of 32 μ m buied on the market, 0.045 ") be fixed on the thin round metal bars with same inner diameter; adopt electroless plating method after the outer surface of polyimide tube evenly plates the thick copper of about 25nm (resistance is 30 Ω); to be spin-coated on the polyimides tube outer surface that is coated with metal level after paraffin is dissolved in the organic solvent chloroform; the thickness of paraffin layer is regulated by the concentration and the spin speed of paraffin organic solution, and according to said method spin coating thickness is the paraffin layer of 124,213,314,425 μ m successively.After treating that solvent evaporates fully, be nested in the polyimide tube with large diameter more, promptly get intelligent duct, carry out hardness test on Electroforce electromagnetism dynamic and static mechanics test machine (Bose company), its result as shown in Figure 2.
Become the process of 200mA from 0 at current signal, the intelligent duct firmness change scope of these four groups of different-thickness is respectively 2.3-0.6GPa (124 μ m), (1.72-0.48GPa 213 μ m), 1.25-0.25GPa (314 μ m), 1.16-0.17GPa (425 μ m).
Under the same experimental conditions, the firmness change of existing commercial guiding catheter (2F-8F) interval is 1.24-1.09GPa.This shows that adjustable hardness intelligent duct of the present invention has the adjustable interval of the hardness wideer than existing guiding catheter, obviously is better than existing guiding catheter on performance.
The suitability for industrialized production of intelligent duct
Make suitable modification in the technological process of existing conduit, promptly adopt the compound mode of extruding that outer tube, responsive to temperature high molecular polymer and inner tube are extruded jointly, tube wall available metal silk or net strengthen.Additionally increase the metallic resistance layer as need, available chemical plating plates the skim metal at interior pipe layer outer surface, and the time of control chemical plating is to regulate resistance sizes.
Claims (9)
1. adjustable hardness intelligent duct that is used for clinical interventional therapy, described conduit comprises outer catheter (1) and interior pipe (3), it is characterized in that being coated with on the outer catheter (1) responsive to temperature high polymer layer (4).
2. a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy according to claim 1, it is characterized in that described outer catheter (1) material is block polyurethane, nylon, polyethylene or polrvinyl chloride, interior pipe (3) material is politef or block polyurethane; Pipe (3) outer wall has metal enhancement layer (2) or metallic resistance layer (5) in described.
3. a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy according to claim 1 is characterized in that described responsive to temperature high polymer layer (4) is coated in the outer wall of outer catheter (1).
4. a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy according to claim 1 is characterized in that (4) employing of described responsive to temperature high molecular polymerization layer and outer tube, the compound extrusion way of interior pipe.
5. a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy according to claim 1 is characterized in that described responsive to temperature high molecular polymer (4) has biocompatibility, and glass transition temperature or fusing point are near blood heat's scope.
6. a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy according to claim 1 is characterized in that described responsive to temperature high molecular polymerization layer (4) is one or more of paraffin, polycaprolactone, polyurethane, polyvinyl acetate.
7. a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy according to claim 1 is characterized in that the complex of described responsive to temperature high molecular polymerization layer (4) for one or more and inorganic nano-particle of paraffin, polycaprolactone, polyurethane, polyvinyl acetate.
8. a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy according to claim 1 is characterized in that described metallic resistance layer (5) adopts plating, chemical plating or magnetron sputtering mode to be plated on the outer wall of inner tube.
9. a kind of adjustable hardness intelligent duct that is used for clinical interventional therapy according to claim 1 is characterized in that described agent structure can adopt existing guide-tube structure, and metal enhancement layer (2) is arranged on the outer wall of inner tube (3); Also can adopt to contain responsive to temperature high polymer layer structure, metallic resistance layer (5) is arranged on the outer wall of inner tube (3).
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010528685 CN102058927A (en) | 2010-10-29 | 2010-10-29 | Hardness-controlled intelligent conduit for clinical intervention treatment |
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| CN 201010528685 CN102058927A (en) | 2010-10-29 | 2010-10-29 | Hardness-controlled intelligent conduit for clinical intervention treatment |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104736058A (en) * | 2012-11-05 | 2015-06-24 | 林治远 | Plastic blood lancet |
| CN107050623A (en) * | 2016-12-29 | 2017-08-18 | 杭州思客医学科技有限公司 | A kind of variable durometer seal wire |
| CN107737399A (en) * | 2017-11-15 | 2018-02-27 | 董鹏 | One kind inflation break-through conduit |
| CN109999317A (en) * | 2019-05-21 | 2019-07-12 | 心凯诺医疗科技(上海)有限公司 | A kind of conduit and intervention device of adjustable hardness |
| CN111050835A (en) * | 2017-09-05 | 2020-04-21 | 苏黎世联邦理工学院 | Steerable catheter with sections of different stiffness |
| CN115154844A (en) * | 2022-08-11 | 2022-10-11 | 临沂市兴华医用器材有限公司 | Anesthesia catheter capable of being bent directionally and anesthesia device |
| CN115253020A (en) * | 2022-08-11 | 2022-11-01 | 临沂市兴华医用器材有限公司 | Anesthesia catheter subassembly that can injury-proof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040131863A1 (en) * | 2002-10-29 | 2004-07-08 | Belliveau Brian Peter | Multilayered articles having biocompatibility and biostability characteristics |
| US20060211979A1 (en) * | 2004-09-24 | 2006-09-21 | Smith Kevin W | Methods for operating a selective stiffening catheter |
| US20080009831A1 (en) * | 2004-12-03 | 2008-01-10 | Scimed Life Systems, Inc. | Selectively flexible catheter and method of use |
-
2010
- 2010-10-29 CN CN 201010528685 patent/CN102058927A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040131863A1 (en) * | 2002-10-29 | 2004-07-08 | Belliveau Brian Peter | Multilayered articles having biocompatibility and biostability characteristics |
| US20060211979A1 (en) * | 2004-09-24 | 2006-09-21 | Smith Kevin W | Methods for operating a selective stiffening catheter |
| US20080009831A1 (en) * | 2004-12-03 | 2008-01-10 | Scimed Life Systems, Inc. | Selectively flexible catheter and method of use |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104736058A (en) * | 2012-11-05 | 2015-06-24 | 林治远 | Plastic blood lancet |
| CN107050623A (en) * | 2016-12-29 | 2017-08-18 | 杭州思客医学科技有限公司 | A kind of variable durometer seal wire |
| CN111050835A (en) * | 2017-09-05 | 2020-04-21 | 苏黎世联邦理工学院 | Steerable catheter with sections of different stiffness |
| CN107737399A (en) * | 2017-11-15 | 2018-02-27 | 董鹏 | One kind inflation break-through conduit |
| CN109999317A (en) * | 2019-05-21 | 2019-07-12 | 心凯诺医疗科技(上海)有限公司 | A kind of conduit and intervention device of adjustable hardness |
| CN115154844A (en) * | 2022-08-11 | 2022-10-11 | 临沂市兴华医用器材有限公司 | Anesthesia catheter capable of being bent directionally and anesthesia device |
| CN115253020A (en) * | 2022-08-11 | 2022-11-01 | 临沂市兴华医用器材有限公司 | Anesthesia catheter subassembly that can injury-proof |
| CN115154844B (en) * | 2022-08-11 | 2023-09-08 | 临沂市兴华医用器材有限公司 | Anesthesia catheter capable of being bent directionally and anesthesia device |
| CN115253020B (en) * | 2022-08-11 | 2023-10-03 | 临沂市兴华医用器材有限公司 | Can prevent anesthesia pipe subassembly of damage |
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Application publication date: 20110518 |