CN101503373B - 2-氨基-1-(4-硝基苯基)-1-乙醇类金属蛋白酶抑制剂及其制备方法和用途 - Google Patents

2-氨基-1-(4-硝基苯基)-1-乙醇类金属蛋白酶抑制剂及其制备方法和用途 Download PDF

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Publication number: CN101503373B
Authority: CN; China
Prior art keywords: amino; compound; nitrophenyl; hydroxyl; acid
Prior art date: 2009-03-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CN2009100198172A

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English (en)

Chinese (zh)

Other versions

CN101503373A (zh

Inventor

徐文方

杨康辉

方浩

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Shandong University

Original Assignee

Shandong University

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-13

Filing date

2009-03-13

Publication date

2013-07-24

2009-03-13 Application filed by Shandong University filed Critical Shandong University

2009-03-13 Priority to CN2009100198172A priority Critical patent/CN101503373B/zh

2009-08-12 Publication of CN101503373A publication Critical patent/CN101503373A/zh

2013-07-24 Application granted granted Critical

2013-07-24 Publication of CN101503373B publication Critical patent/CN101503373B/zh

Status Expired - Fee Related legal-status Critical Current

2029-03-13 Anticipated expiration legal-status Critical

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0 CC(C)(C)OC(N[C@@](CNC(*)=O)[C@](c(cc1)ccc1[N+]([O-])=O)O)=O Chemical compound CC(C)(C)OC(N[C@@](CNC(*)=O)[C@](c(cc1)ccc1[N+]([O-])=O)O)=O 0.000 description 7
XABMLWYGVXKUAO-RYUDHWBXSA-N CC(C)(C)OC(N[C@@H](CBr)[C@H](c(cc1)ccc1[N+]([O-])=O)O)=O Chemical compound CC(C)(C)OC(N[C@@H](CBr)[C@H](c(cc1)ccc1[N+]([O-])=O)O)=O XABMLWYGVXKUAO-RYUDHWBXSA-N 0.000 description 1
IJZRJHBKWDMDLS-RYUDHWBXSA-N CC(C)(C)OC(N[C@@H](CN)[C@H](c(cc1)ccc1[N+]([O-])=O)O)=O Chemical compound CC(C)(C)OC(N[C@@H](CN)[C@H](c(cc1)ccc1[N+]([O-])=O)O)=O IJZRJHBKWDMDLS-RYUDHWBXSA-N 0.000 description 1
VQYVJTCEEOYKHE-RYUDHWBXSA-N CC(C)(C)OC(N[C@@H](CO)[C@H](c(cc1)ccc1[N+]([O-])=O)O)=O Chemical compound CC(C)(C)OC(N[C@@H](CO)[C@H](c(cc1)ccc1[N+]([O-])=O)O)=O VQYVJTCEEOYKHE-RYUDHWBXSA-N 0.000 description 1
JOIWPCUDRRYOQH-UHFFFAOYSA-N CCCC(C)[N+]([O-])=O Chemical compound CCCC(C)[N+]([O-])=O JOIWPCUDRRYOQH-UHFFFAOYSA-N 0.000 description 1

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Classifications

- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

CN2009100198172A 2009-03-13 2009-03-13 2-氨基-1-(4-硝基苯基)-1-乙醇类金属蛋白酶抑制剂及其制备方法和用途 Expired - Fee Related CN101503373B (zh)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CN2009100198172A CN101503373B (zh)	2009-03-13	2009-03-13	2-氨基-1-(4-硝基苯基)-1-乙醇类金属蛋白酶抑制剂及其制备方法和用途

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CN2009100198172A CN101503373B (zh)	2009-03-13	2009-03-13	2-氨基-1-(4-硝基苯基)-1-乙醇类金属蛋白酶抑制剂及其制备方法和用途

Publications (2)

Publication Number	Publication Date
CN101503373A CN101503373A (zh)	2009-08-12
CN101503373B true CN101503373B (zh)	2013-07-24

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CN2009100198172A Expired - Fee Related CN101503373B (zh)	2009-03-13	2009-03-13	2-氨基-1-(4-硝基苯基)-1-乙醇类金属蛋白酶抑制剂及其制备方法和用途

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Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1546088T1 (sl)	2002-10-03	2015-04-30	Novaremed Ltd.	Spojine za uporabo v zdravljenju avtoimunskih bolezni, imunoalergijskih bolezni in zavrnitve transpalantata organa ali tkiva
EP1750691B1 (en)	2004-03-26	2016-08-10	Novaremed Ltd.	Compounds for treatment of aids and other diseases
GB0804213D0 (en) *	2008-03-06	2008-04-16	New Era Biotech Ltd	A method of printing or preventing pain
US8802734B2 (en)	2009-09-09	2014-08-12	Novaremed Limited	Method of treating or preventing pain
US20150018566A1 (en)	2011-08-25	2015-01-15	The Provost, Fellows, Foundation Scholars, & the Other Members of Board, of The College of the Holy	Tubulin binding agents
EP3964497A1 (en) *	2020-09-04	2022-03-09	Friedrich-Alexander-Universität Erlangen-Nürnberg	Substituted vicinal diamine compounds and their use in the treatment, amelioration or prevention of pain

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1566065A (zh) *	2003-06-27	2005-01-19	中国医学科学院药物研究所	α位杂原子取代的γ芳基丁本酮酸衍生物及其制法和其药物组合物与用途

2009
- 2009-03-13 CN CN2009100198172A patent/CN101503373B/zh not_active Expired - Fee Related

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1566065A (zh) *	2003-06-27	2005-01-19	中国医学科学院药物研究所	α位杂原子取代的γ芳基丁本酮酸衍生物及其制法和其药物组合物与用途

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JP特开2004-277291A 2004.10.07
Medicinal Chemistry Letters》.2004,第15卷(第4期),1115-1119. *
Teiichi Murakami et al.Synthesis and biological properties of novel sphingosine derivatives.《Bioorganic & Medicinal Chemistry Letters》.2004,第15卷(第4期),1115-1119.
Teiichi Murakami et al.Synthesis and biological properties of novel sphingosine derivatives.《Bioorganic &amp *

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2009-08-12	C06	Publication
2009-08-12	PB01	Publication
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2013-07-24	C14	Grant of patent or utility model
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2017-05-03	CF01	Termination of patent right due to non-payment of annual fee	Granted publication date: 20130724 Termination date: 20160313
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