CA2647850A1 - Apparatus and method for vascular embolization - Google Patents
Apparatus and method for vascular embolization Download PDFInfo
- Publication number
- CA2647850A1 CA2647850A1 CA002647850A CA2647850A CA2647850A1 CA 2647850 A1 CA2647850 A1 CA 2647850A1 CA 002647850 A CA002647850 A CA 002647850A CA 2647850 A CA2647850 A CA 2647850A CA 2647850 A1 CA2647850 A1 CA 2647850A1
- Authority
- CA
- Canada
- Prior art keywords
- embolic device
- deployment
- state
- elongate
- polymeric material
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002792 vascular Effects 0.000 title claims abstract 15
- 230000010102 embolization Effects 0.000 title claims abstract 3
- 230000003073 embolic effect Effects 0.000 claims abstract 23
- 239000000463 material Substances 0.000 claims abstract 14
- 239000008280 blood Substances 0.000 claims abstract 7
- 210000004369 blood Anatomy 0.000 claims abstract 7
- 230000007797 corrosion Effects 0.000 claims abstract 4
- 238000005260 corrosion Methods 0.000 claims abstract 4
- 239000007788 liquid Substances 0.000 claims abstract 3
- 239000002184 metal Substances 0.000 claims abstract 3
- 238000001125 extrusion Methods 0.000 claims abstract 2
- 230000037431 insertion Effects 0.000 claims abstract 2
- 238000003780 insertion Methods 0.000 claims abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- LZCLXQDLBQLTDK-UHFFFAOYSA-N ethyl 2-hydroxypropanoate Chemical compound CCOC(=O)C(C)O LZCLXQDLBQLTDK-UHFFFAOYSA-N 0.000 claims 2
- 239000012530 fluid Substances 0.000 claims 2
- 230000007704 transition Effects 0.000 claims 2
- 229920001651 Cyanoacrylate Polymers 0.000 claims 1
- MWCLLHOVUTZFKS-UHFFFAOYSA-N Methyl cyanoacrylate Chemical compound COC(=O)C(=C)C#N MWCLLHOVUTZFKS-UHFFFAOYSA-N 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 229940116333 ethyl lactate Drugs 0.000 claims 1
- 235000019808 microcrystalline wax Nutrition 0.000 claims 1
- 239000004200 microcrystalline wax Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000004014 plasticizer Substances 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- 239000007769 metal material Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12163—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device having a string of elements connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/12186—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices liquid materials adapted to be injected
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/12195—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices comprising a curable material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
- A61B2017/12054—Details concerning the detachment of the occluding device from the introduction device
- A61B2017/12063—Details concerning the detachment of the occluding device from the introduction device electrolytically detachable
Abstract
Apparatus for vascular embolization, deployable through a microtcatheter, includes a flexible, elongate deployment tube dimensioned for insertion through the microcatheter, and a filamentous embolic device releasably attached to the distal end of the tube.
The embolic device is controllably transformable from a soft, compliant state to a rigid or semi-rigid state. The embolic device may include a polymeric material that is transformable by contact with vascular blood or with a liquid that is cooler than vascular blood, or it may include a metallic material that is transformable by electrolytic corrosion. The embolic device may be a continuous filamentous polymeric extrusion; an elongate microcoil filled with polymeric material; an elongate, multi-segmented chain including polymeric interconnecting portions; or an elongate chain of metal segments that are fused together by electrolytic corrosion.
The embolic device is controllably transformable from a soft, compliant state to a rigid or semi-rigid state. The embolic device may include a polymeric material that is transformable by contact with vascular blood or with a liquid that is cooler than vascular blood, or it may include a metallic material that is transformable by electrolytic corrosion. The embolic device may be a continuous filamentous polymeric extrusion; an elongate microcoil filled with polymeric material; an elongate, multi-segmented chain including polymeric interconnecting portions; or an elongate chain of metal segments that are fused together by electrolytic corrosion.
Claims (20)
1. Apparatus for vascular embolization that is deployable through a microcatheter having an axial lumen, comprising:
a flexible, elongate, hollow deployment tube dimensioned for insertion through the lumen of the microcatheter, the deployment tube having a proximal end and a distal end; and a filamentous embolic device having a proximal end detachably connected to the distal end of the deployment tube;
characterized in that the proximal end of the embolic device is detachable from the distal end of the deployment tube by the application of fluid pressure from the deployment tube to the proximal end of the embolic device, and in that the embolic device is controllably transformable from a pre-deployment state to a post-deployment state.
a flexible, elongate, hollow deployment tube dimensioned for insertion through the lumen of the microcatheter, the deployment tube having a proximal end and a distal end; and a filamentous embolic device having a proximal end detachably connected to the distal end of the deployment tube;
characterized in that the proximal end of the embolic device is detachable from the distal end of the deployment tube by the application of fluid pressure from the deployment tube to the proximal end of the embolic device, and in that the embolic device is controllably transformable from a pre-deployment state to a post-deployment state.
2. The apparatus of Claim 1, wherein the pre-deployment state is a soft, compliant state and the post-deployment state is a rigid or semi-rigid state.
3. The apparatus of Claim 2, wherein the embolic device is transformable by contact with vascular blood.
4. The apparatus of Claim 2, wherein the embolic device is controllably transformable by contact with a biocompatible liquid that is cooler than vascular blood.
5. The apparatus of Claim 1, wherein the embolic device includes a polymeric material that is controllably transformable from a soft, compliant state to a rigid or semi-rigid state.
6. The apparatus of Claim 5, wherein the polymeric material includes a microcrystalline wax composition.
7. The apparatus of Claim 5, wherein the polymeric material is selected from the group consisting of cellulose acetate polymers and polyurethane-based copolymers.
8. The apparatus of Claim 7, wherein the plasticizer is selected from a group consisting of dimethylsulfoxide, ethyl lactate, and ethanol.
9. The apparatus of any of Claims 5 through 8, wherein the embolic device comprises a continuous extrusion of the polymeric material.
10. The apparatus of Claim 3, wherein the embolic device comprises an elongate, flexible microcoil having a hollow interior containing a polymeric material.
11. The apparatus of any of Claims 5 through 8, wherein the embolic device comprises an elongate, flexible chain of multiple interlinked segments, at least some of which include an interlinking portion made of the polymeric material.
12. The apparatus of Claim 1, wherein the embolic device comprises an elongate, flexible chain of multiple interlinked metal segments, wherein the chain is transformable by electrolytic- corrosion.
13. The apparatus of Claim 1, wherein the embolic device comprises an elongate, flexible chain of multiple interlinked hollow segments filled with the polymeric material.
14. The apparatus of any one of Claims 10 or 13, wherein the polymeric material is cyanoacrylate.
15. Use of an elongate filamentous embolic device as an apparatus for embolizing a vascular site, wherein said device is controllably transformable from a pre-deployment state in the vascular site to a post-deployment state after deployment in the vascular site, and wherein said device is deployable through a catheter having a distal end adjacent the vascular site, where the device has a filamentous form before it is inserted into the catheter and forms a web-like mass in the vascular site as it transforms from its pre-deployment state to its post-deployment state.
16. Use according to claim 15, wherein the embolic device is used in conjunction with an elongate, flexible deployment tube wherein the proximal end of the embolic device attaches to the distal end of the deployment tube and wherein fluid is used to push the deployment tube through the catheter until the embolic device is deployed in the vascular site and detached from the deployment tube.
17. Use according to claim 15 or claim 16 wherein the embolic device includes a portion made of polymeric material that is transformable from a soft pre-deployment state to the post-deployment state, and wherein a polymeric portion contacts vascular blood.
18. Use according to claim 15 or claim 16 wherein the embolic device includes a portion made of a polymeric material that is transformable from the pre-deployment state to the post-deployment state, and wherein contact with a biocompatible liquid that is cooler than blood transforms the device to the rigid or semi-rigid state.
19. Use according to claim 15 or claim 16, wherein the device comprises an elongate, flexible chain of multiple interlinked metal segments, and wherein electrolytic corrosion of the elements transforms the device to the rigid or semi-rigid state.
20. Use according to claim 15 or claim 16, wherein the embolic device has a hollow interior into which a transition material is inserted and wherein said transition material is transformed upon contact with vascular blood.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2736639A CA2736639A1 (en) | 1998-04-28 | 1999-04-23 | Apparatus and method for vascular embolization |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/069008 | 1998-04-28 | ||
US09/069,008 US6015424A (en) | 1998-04-28 | 1998-04-28 | Apparatus and method for vascular embolization |
CA002330136A CA2330136C (en) | 1998-04-28 | 1999-04-23 | Apparatus and method for vascular embolization |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002330136A Division CA2330136C (en) | 1998-04-28 | 1999-04-23 | Apparatus and method for vascular embolization |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2736639A Division CA2736639A1 (en) | 1998-04-28 | 1999-04-23 | Apparatus and method for vascular embolization |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2647850A1 true CA2647850A1 (en) | 1999-11-04 |
CA2647850C CA2647850C (en) | 2011-06-21 |
Family
ID=22086109
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002330136A Expired - Fee Related CA2330136C (en) | 1998-04-28 | 1999-04-23 | Apparatus and method for vascular embolization |
CA2647850A Expired - Fee Related CA2647850C (en) | 1998-04-28 | 1999-04-23 | Apparatus and method for vascular embolization |
CA2736639A Abandoned CA2736639A1 (en) | 1998-04-28 | 1999-04-23 | Apparatus and method for vascular embolization |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002330136A Expired - Fee Related CA2330136C (en) | 1998-04-28 | 1999-04-23 | Apparatus and method for vascular embolization |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2736639A Abandoned CA2736639A1 (en) | 1998-04-28 | 1999-04-23 | Apparatus and method for vascular embolization |
Country Status (11)
Country | Link |
---|---|
US (2) | US6015424A (en) |
EP (3) | EP1806106B1 (en) |
JP (2) | JP4376458B2 (en) |
CN (1) | CN1200648C (en) |
AT (2) | ATE359031T1 (en) |
AU (4) | AU764797C (en) |
BR (1) | BR9910027A (en) |
CA (3) | CA2330136C (en) |
DE (2) | DE69935814T2 (en) |
ES (3) | ES2384988T3 (en) |
WO (1) | WO1999055239A1 (en) |
Families Citing this family (209)
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- 1999-04-23 EP EP07104770A patent/EP1806106B1/en not_active Expired - Lifetime
- 1999-04-23 DE DE69935814T patent/DE69935814T2/en not_active Expired - Lifetime
- 1999-04-23 ES ES07104770T patent/ES2384988T3/en not_active Expired - Lifetime
- 1999-04-23 DE DE69921979T patent/DE69921979T2/en not_active Expired - Lifetime
- 1999-04-23 ES ES99921377T patent/ES2232136T3/en not_active Expired - Lifetime
- 1999-04-23 AT AT04019762T patent/ATE359031T1/en not_active IP Right Cessation
- 1999-04-23 CA CA2647850A patent/CA2647850C/en not_active Expired - Fee Related
- 1999-04-23 JP JP2000545447A patent/JP4376458B2/en not_active Expired - Fee Related
- 1999-04-23 ES ES04019762T patent/ES2285319T3/en not_active Expired - Lifetime
- 1999-04-23 EP EP99921377A patent/EP1073377B1/en not_active Expired - Lifetime
- 1999-04-23 EP EP04019762A patent/EP1518502B1/en not_active Expired - Lifetime
- 1999-04-23 WO PCT/US1999/007399 patent/WO1999055239A1/en active IP Right Grant
- 1999-04-23 AT AT99921377T patent/ATE282362T1/en not_active IP Right Cessation
- 1999-04-23 CA CA2736639A patent/CA2736639A1/en not_active Abandoned
- 1999-04-23 CN CNB998056081A patent/CN1200648C/en not_active Expired - Fee Related
- 1999-04-23 AU AU38609/99A patent/AU764797C/en not_active Ceased
- 1999-04-23 BR BR9910027-4A patent/BR9910027A/en not_active IP Right Cessation
- 1999-12-23 US US09/471,507 patent/US6375669B1/en not_active Expired - Lifetime
-
2003
- 2003-11-26 AU AU2003264582A patent/AU2003264582B2/en not_active Ceased
-
2006
- 2006-12-06 AU AU2006249217A patent/AU2006249217B2/en not_active Ceased
-
2007
- 2007-03-01 JP JP2007051457A patent/JP4794477B2/en not_active Expired - Fee Related
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2009
- 2009-04-29 AU AU2009201669A patent/AU2009201669A1/en not_active Abandoned
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