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Publication numberCA2577018 A1
Publication typeApplication
Application numberCA 2577018
PCT numberPCT/US2005/028228
Publication dateFeb 23, 2006
Filing dateAug 9, 2005
Priority dateAug 13, 2004
Also published asCA2577018C, CN101014642A, CN101014642B, EP1778761A1, US7473417, US20060036316, WO2006020616A1
Publication numberCA 2577018, CA 2577018 A1, CA 2577018A1, CA-A1-2577018, CA2577018 A1, CA2577018A1, PCT/2005/28228, PCT/US/2005/028228, PCT/US/2005/28228, PCT/US/5/028228, PCT/US/5/28228, PCT/US2005/028228, PCT/US2005/28228, PCT/US2005028228, PCT/US200528228, PCT/US5/028228, PCT/US5/28228, PCT/US5028228, PCT/US528228
InventorsDonald K. Brandom, Joan Zeltinger
ApplicantReva Medical, Inc., Donald K. Brandom, Joan Zeltinger
Export CitationBiBTeX, EndNote, RefMan
External Links: CIPO, Espacenet
Inherently radiopaque bioresorbable polymers for multiple uses
CA 2577018 A1
Abstract
Preferred embodiments of the present invention relate to polymeric medical devices, such as stents. More particularly, the compositions disclosed herein comprise halogen-containing phenol moeities, that may be used for medical devices and other uses whereby bioresorbable and radiopaque and physicomechanical properties are desired.
Description  available in
Claims(30)
1. An inherently radiopaque, biocompatible, bioresorbable polymer, wherein said polymer comprises one or more recurring units of the Formula (I):

wherein:
X1 and X2 are each independently selected from the group consisting of Br and I;
y1 and y2 are each independently zero or an integer in the range of 1 to 4, with the proviso that the sum of y1 and y2 is at least 1;

R1 is R13 and R14 are each independently selected from the group consisting of -CH=CH-, -(CH2)c-, -(CHJ1)-, -CHJ2-CHJ3-, -CH=CH-(CHJ1)-, and -(CH2),-(CHJ1 )-;
c is zero or an integer in the range of 1 to 8;
J1, J2 and J3 are each independently selected from the group consisting of H, Br, I, -NH-Q2 and -C(=Z8)-OQ3;
Q1, Q2 and Q3 are each independently H or a non-crystallizable group comprising from about 1 to about 30 carbons;
Z7 and Z8 are each independetly O or S;
A1 is selected from the group consisting of R5 is selected from the group consisting of H, C1 - C30 alkyl, and C1 - C30 heteroalkyl.
2. A medical device comprising the polymer of Claim 1.
3. The medical device of Claim 2, wherein said medical device is configured for placement in a region selected from vascular, musculoskeletal/orthopedic, nervous, respiratory, reproductive, urinary, digestive, endocrine, hematopoietic, or integumentary system.
4. The medical device of Claim 2, wherein said medical device is configured for use in vivo.
5. The medical device of Claim 2, wherein said medical device is configured for use ex vivo.
6. The medical device of Claim 5, wherein said medical device is configured for use in vitro.
7. The medical device of Claim 2, wherein said medical device comprises a stent.
8. The medical device of Claim 7, wherein said stent further comprises a configuration selected from the group consisting of a sheet stent, a braided stent, a self-expanding stent, a wire stent, a deformable stent, and a slide-and-lock stent.
9. The medical device of Claim 7, wherein said stent comprises at least two substantially non-deforming elements arranged to form a tubular member, the non-deforming elements being slidably interconnected for allowing the tubular member to expand from a collapsed diameter to an expanded diameter.
10. The medical device of Claim 7, wherein said stent further comprises a tubular member comprising a series of slideably-engaged radial elements and a locking mechanism adapted to permit one-way sliding of the radial elements, such that said tubular member is configured to expand from a first collapsed diameter to a second expanded diameter with minimum recoil.
11. The medical device of Claim 2, further comprising an effective amount of a therapeutic agent.
12. The medical device of Claim 11, wherein said therapeutic agent is selected from the group consisting of antiproliferative agent, anti-inflammatory agent, anti-matrix metalloproteinase agent, lipid lowering agent, cholesterol modifying agent, anti-thrombotic agent, and antiplatelet agent.
13. The medical device of Claim 11, wherein said effective amount is sufficient to provide an effect selected from the group consisting of inhibition of restenosis, inhibition of thrombosis, inhibition of plaque formation, inhibition of plaque rupture, inhibition of inflammation, lowering of cholesterol, and promote healing.
14. The medical device of Claim 2, wherein X1 and X2 are iodine.
15. The medical device of Claim 2 further comprising a non-halogenated coating.
16. The medical device of Claim 2, wherein said polymer forms a coating on at least a portion of said medical device.
17. A system for treating a site within a vessel, comprising the stent of Claim 7 and a catheter having a deployment means, wherein said catheter is adapted to deliver the stent to said site and said deployment means is adapted to deploy the stent.
18. A method for re-treatment of a body lumen, comprising:
deploying a first stent along a region within a blood vessel, wherein said first stent is the stent of Claim 7, and wherein said first stent resides for a period of time; and deploying at a later time a second stent, along the approximate same region within the blood vessel, such that the blood vessel is re-treated.
19. The polymer of Claim 1, further comprising one or more recurring units of the Formula (II):

wherein:
B is -O-(CHR6)p O)q-;

R6 is H or C1 to C3 alkyl;
p and q are each individually an integer in the range of about 1 to about 100;

A2 is selected from the group consisting of R7 is H or a C, to C30 hydrocarbon; and R11 is selected from the group consisting of C1 - C30 alkyl, C1 - C30 heteroalkyl, C5 - C30 aryl, C6 - C30 alkylaryl, and C2 - C30 heteroaryl.
20. A medical device comprising the polymer of Claim 19.
21. The polymer of Claim 19, further comprising one or more recurring units of the Formula (Ia):

wherein:
X3 and X4 are each independently selected from the group consisting of Br and I;
y3 and y4 are each independently zero or an integer in the range of 1 to 4;
R2 is selected from the group consisting of:

R8 and R9 are each independently H or a non-crystallizable C1 to C30 hydrocarbon;
Z4, Z5 and Z6 are each independently O or S;
a and b are each independently an integer in the range of 1 to 8;
A3 is selected from the group consisting of R10 is selected from the group consisting of H, C1 - C30 alkyl, and C1 - C30 heteroalkyl; and R12 is selected from the group consisting of C1 - C30 alkyl, C1 - C30 heteroalkyl, C5 - C30 aryl, C6 - C30 alkylaryl, and C2 - C30 heteroaryl.
22. A medical device comprising the polymer of Claim 21.
23. The polymer of Claim 1, wherein R1 is:

wherein R3 is H or a non-crystallizable C1 to C29 hydrocarbon;
Z1 and Z2 are each independently O or S; and m is an integer in the range of 1 to 8.
24. A medical device comprising the polymer of Claim 23.
25. The polymer of Claim 1, wherein R1 is:

wherein R3 is H or a non-crystallizable C, to C29 hydrocarbon;
Z1 and Z2 are each independently O or S; and j and m are each independently an integer in the range of 1 to 8.
26. A medical device comprising the polymer of Claim 25.
27. The polymer of Claim 1, wherein R1 is:

wherein R3 and R4 are each independently H or a non-crystallizable C1 to C29 hydrocarbon;
Z1, Z2 and Z3 are each independently O or S; and j and m are each independently an integer in the range of 1 to 8.
28. A medical device comprising the polymer of Claim 27.
29. The medical device of Claim 2, further comprising an effective amount of a radiopacifying agent.
30. The medical device of Claim 2, further comprising an effective amount of a magnetic resonance enhancing agent.
Classifications
International ClassificationC08G63/685, C08G64/12, C08G65/40
Cooperative ClassificationB33Y70/00, A61F2210/0004, A61F2002/91533, C08G65/4006, A61K49/0442, A61F2/91, C08G64/18, A61L31/18, B33Y80/00, C08G64/08, A61F2/915, A61F2002/91591
European ClassificationA61F2/915, A61F2/91, C08G64/08, A61L31/18, A61K49/04H4, C08G64/18, C08G65/40B
Legal Events
DateCodeEventDescription
Feb 12, 2007EEERExamination request