CA2577018A1 - Inherently radiopaque bioresorbable polymers for multiple uses - Google Patents
Inherently radiopaque bioresorbable polymers for multiple uses Download PDFInfo
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- CA2577018A1 CA2577018A1 CA002577018A CA2577018A CA2577018A1 CA 2577018 A1 CA2577018 A1 CA 2577018A1 CA 002577018 A CA002577018 A CA 002577018A CA 2577018 A CA2577018 A CA 2577018A CA 2577018 A1 CA2577018 A1 CA 2577018A1
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/38—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives derived from phenols
- C08G65/40—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives derived from phenols from phenols (I) and other compounds (II), e.g. OH-Ar-OH + X-Ar-X, where X is halogen atom, i.e. leaving group
- C08G65/4006—(I) or (II) containing elements other than carbon, oxygen, hydrogen or halogen as leaving group (X)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/18—Materials at least partially X-ray or laser opaque
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/04—Aromatic polycarbonates
- C08G64/06—Aromatic polycarbonates not containing aliphatic unsaturation
- C08G64/08—Aromatic polycarbonates not containing aliphatic unsaturation containing atoms other than carbon, hydrogen or oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
- C08G64/18—Block or graft polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91591—Locking connectors, e.g. using male-female connections
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y70/00—Materials specially adapted for additive manufacturing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B33—ADDITIVE MANUFACTURING TECHNOLOGY
- B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
- B33Y80/00—Products made by additive manufacturing
Abstract
Preferred embodiments of the present invention relate to polymeric medical devices, such as stents. More particularly, the compositions disclosed herein comprise halogen-containing phenol moeities, that may be used for medical devices and other uses whereby bioresorbable and radiopaque and physicomechanical properties are desired.
Claims (30)
1. An inherently radiopaque, biocompatible, bioresorbable polymer, wherein said polymer comprises one or more recurring units of the Formula (I):
wherein:
X1 and X2 are each independently selected from the group consisting of Br and I;
y1 and y2 are each independently zero or an integer in the range of 1 to 4, with the proviso that the sum of y1 and y2 is at least 1;
R1 is R13 and R14 are each independently selected from the group consisting of -CH=CH-, -(CH2)c-, -(CHJ1)-, -CHJ2-CHJ3-, -CH=CH-(CHJ1)-, and -(CH2),-(CHJ1 )-;
c is zero or an integer in the range of 1 to 8;
J1, J2 and J3 are each independently selected from the group consisting of H, Br, I, -NH-Q2 and -C(=Z8)-OQ3;
Q1, Q2 and Q3 are each independently H or a non-crystallizable group comprising from about 1 to about 30 carbons;
Z7 and Z8 are each independetly O or S;
A1 is selected from the group consisting of R5 is selected from the group consisting of H, C1 - C30 alkyl, and C1 - C30 heteroalkyl.
wherein:
X1 and X2 are each independently selected from the group consisting of Br and I;
y1 and y2 are each independently zero or an integer in the range of 1 to 4, with the proviso that the sum of y1 and y2 is at least 1;
R1 is R13 and R14 are each independently selected from the group consisting of -CH=CH-, -(CH2)c-, -(CHJ1)-, -CHJ2-CHJ3-, -CH=CH-(CHJ1)-, and -(CH2),-(CHJ1 )-;
c is zero or an integer in the range of 1 to 8;
J1, J2 and J3 are each independently selected from the group consisting of H, Br, I, -NH-Q2 and -C(=Z8)-OQ3;
Q1, Q2 and Q3 are each independently H or a non-crystallizable group comprising from about 1 to about 30 carbons;
Z7 and Z8 are each independetly O or S;
A1 is selected from the group consisting of R5 is selected from the group consisting of H, C1 - C30 alkyl, and C1 - C30 heteroalkyl.
2. A medical device comprising the polymer of Claim 1.
3. The medical device of Claim 2, wherein said medical device is configured for placement in a region selected from vascular, musculoskeletal/orthopedic, nervous, respiratory, reproductive, urinary, digestive, endocrine, hematopoietic, or integumentary system.
4. The medical device of Claim 2, wherein said medical device is configured for use in vivo.
5. The medical device of Claim 2, wherein said medical device is configured for use ex vivo.
6. The medical device of Claim 5, wherein said medical device is configured for use in vitro.
7. The medical device of Claim 2, wherein said medical device comprises a stent.
8. The medical device of Claim 7, wherein said stent further comprises a configuration selected from the group consisting of a sheet stent, a braided stent, a self-expanding stent, a wire stent, a deformable stent, and a slide-and-lock stent.
9. The medical device of Claim 7, wherein said stent comprises at least two substantially non-deforming elements arranged to form a tubular member, the non-deforming elements being slidably interconnected for allowing the tubular member to expand from a collapsed diameter to an expanded diameter.
10. The medical device of Claim 7, wherein said stent further comprises a tubular member comprising a series of slideably-engaged radial elements and a locking mechanism adapted to permit one-way sliding of the radial elements, such that said tubular member is configured to expand from a first collapsed diameter to a second expanded diameter with minimum recoil.
11. The medical device of Claim 2, further comprising an effective amount of a therapeutic agent.
12. The medical device of Claim 11, wherein said therapeutic agent is selected from the group consisting of antiproliferative agent, anti-inflammatory agent, anti-matrix metalloproteinase agent, lipid lowering agent, cholesterol modifying agent, anti-thrombotic agent, and antiplatelet agent.
13. The medical device of Claim 11, wherein said effective amount is sufficient to provide an effect selected from the group consisting of inhibition of restenosis, inhibition of thrombosis, inhibition of plaque formation, inhibition of plaque rupture, inhibition of inflammation, lowering of cholesterol, and promote healing.
14. The medical device of Claim 2, wherein X1 and X2 are iodine.
15. The medical device of Claim 2 further comprising a non-halogenated coating.
16. The medical device of Claim 2, wherein said polymer forms a coating on at least a portion of said medical device.
17. A system for treating a site within a vessel, comprising the stent of Claim 7 and a catheter having a deployment means, wherein said catheter is adapted to deliver the stent to said site and said deployment means is adapted to deploy the stent.
18. A method for re-treatment of a body lumen, comprising:
deploying a first stent along a region within a blood vessel, wherein said first stent is the stent of Claim 7, and wherein said first stent resides for a period of time; and deploying at a later time a second stent, along the approximate same region within the blood vessel, such that the blood vessel is re-treated.
deploying a first stent along a region within a blood vessel, wherein said first stent is the stent of Claim 7, and wherein said first stent resides for a period of time; and deploying at a later time a second stent, along the approximate same region within the blood vessel, such that the blood vessel is re-treated.
19. The polymer of Claim 1, further comprising one or more recurring units of the Formula (II):
wherein:
B is -O-(CHR6)p O)q-;
R6 is H or C1 to C3 alkyl;
p and q are each individually an integer in the range of about 1 to about 100;
A2 is selected from the group consisting of R7 is H or a C, to C30 hydrocarbon; and R11 is selected from the group consisting of C1 - C30 alkyl, C1 - C30 heteroalkyl, C5 - C30 aryl, C6 - C30 alkylaryl, and C2 - C30 heteroaryl.
wherein:
B is -O-(CHR6)p O)q-;
R6 is H or C1 to C3 alkyl;
p and q are each individually an integer in the range of about 1 to about 100;
A2 is selected from the group consisting of R7 is H or a C, to C30 hydrocarbon; and R11 is selected from the group consisting of C1 - C30 alkyl, C1 - C30 heteroalkyl, C5 - C30 aryl, C6 - C30 alkylaryl, and C2 - C30 heteroaryl.
20. A medical device comprising the polymer of Claim 19.
21. The polymer of Claim 19, further comprising one or more recurring units of the Formula (Ia):
wherein:
X3 and X4 are each independently selected from the group consisting of Br and I;
y3 and y4 are each independently zero or an integer in the range of 1 to 4;
R2 is selected from the group consisting of:
R8 and R9 are each independently H or a non-crystallizable C1 to C30 hydrocarbon;
Z4, Z5 and Z6 are each independently O or S;
a and b are each independently an integer in the range of 1 to 8;
A3 is selected from the group consisting of R10 is selected from the group consisting of H, C1 - C30 alkyl, and C1 - C30 heteroalkyl; and R12 is selected from the group consisting of C1 - C30 alkyl, C1 - C30 heteroalkyl, C5 - C30 aryl, C6 - C30 alkylaryl, and C2 - C30 heteroaryl.
wherein:
X3 and X4 are each independently selected from the group consisting of Br and I;
y3 and y4 are each independently zero or an integer in the range of 1 to 4;
R2 is selected from the group consisting of:
R8 and R9 are each independently H or a non-crystallizable C1 to C30 hydrocarbon;
Z4, Z5 and Z6 are each independently O or S;
a and b are each independently an integer in the range of 1 to 8;
A3 is selected from the group consisting of R10 is selected from the group consisting of H, C1 - C30 alkyl, and C1 - C30 heteroalkyl; and R12 is selected from the group consisting of C1 - C30 alkyl, C1 - C30 heteroalkyl, C5 - C30 aryl, C6 - C30 alkylaryl, and C2 - C30 heteroaryl.
22. A medical device comprising the polymer of Claim 21.
23. The polymer of Claim 1, wherein R1 is:
wherein R3 is H or a non-crystallizable C1 to C29 hydrocarbon;
Z1 and Z2 are each independently O or S; and m is an integer in the range of 1 to 8.
wherein R3 is H or a non-crystallizable C1 to C29 hydrocarbon;
Z1 and Z2 are each independently O or S; and m is an integer in the range of 1 to 8.
24. A medical device comprising the polymer of Claim 23.
25. The polymer of Claim 1, wherein R1 is:
wherein R3 is H or a non-crystallizable C, to C29 hydrocarbon;
Z1 and Z2 are each independently O or S; and j and m are each independently an integer in the range of 1 to 8.
wherein R3 is H or a non-crystallizable C, to C29 hydrocarbon;
Z1 and Z2 are each independently O or S; and j and m are each independently an integer in the range of 1 to 8.
26. A medical device comprising the polymer of Claim 25.
27. The polymer of Claim 1, wherein R1 is:
wherein R3 and R4 are each independently H or a non-crystallizable C1 to C29 hydrocarbon;
Z1, Z2 and Z3 are each independently O or S; and j and m are each independently an integer in the range of 1 to 8.
wherein R3 and R4 are each independently H or a non-crystallizable C1 to C29 hydrocarbon;
Z1, Z2 and Z3 are each independently O or S; and j and m are each independently an integer in the range of 1 to 8.
28. A medical device comprising the polymer of Claim 27.
29. The medical device of Claim 2, further comprising an effective amount of a radiopacifying agent.
30. The medical device of Claim 2, further comprising an effective amount of a magnetic resonance enhancing agent.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US60152604P | 2004-08-13 | 2004-08-13 | |
US60/601,526 | 2004-08-13 | ||
PCT/US2005/028228 WO2006020616A1 (en) | 2004-08-13 | 2005-08-09 | Inherently radiopaque bioresorbable polymers for multiple uses |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2577018A1 true CA2577018A1 (en) | 2006-02-23 |
CA2577018C CA2577018C (en) | 2012-03-27 |
Family
ID=35276651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2577018A Active CA2577018C (en) | 2004-08-13 | 2005-08-09 | Inherently radiopaque bioresorbable polymers for multiple uses |
Country Status (8)
Country | Link |
---|---|
US (1) | US7473417B2 (en) |
EP (1) | EP1778761B1 (en) |
JP (1) | JP4768736B2 (en) |
CN (1) | CN101014642B (en) |
AU (1) | AU2005272944B2 (en) |
CA (1) | CA2577018C (en) |
RU (1) | RU2396289C2 (en) |
WO (1) | WO2006020616A1 (en) |
Families Citing this family (106)
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AU2003270070A1 (en) * | 2002-09-04 | 2004-03-29 | Reva Medical, Inc. | A slide and lock stent and method of manufacture from a single piece shape |
EP1633280A4 (en) * | 2003-06-16 | 2011-03-16 | Univ Nanyang Tech | Polymeric stent and method of manufacture |
WO2005030268A1 (en) | 2003-09-25 | 2005-04-07 | Rutgers, The State University | Inherently radiopaque polymeric products for embolotherapy |
US8052749B2 (en) * | 2003-12-23 | 2011-11-08 | Sadra Medical, Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
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US7959666B2 (en) | 2003-12-23 | 2011-06-14 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a heart valve |
US20050137687A1 (en) | 2003-12-23 | 2005-06-23 | Sadra Medical | Heart valve anchor and method |
US11278398B2 (en) | 2003-12-23 | 2022-03-22 | Boston Scientific Scimed, Inc. | Methods and apparatus for endovascular heart valve replacement comprising tissue grasping elements |
AU2005269868B2 (en) | 2004-07-08 | 2008-10-23 | Reva Medical, Inc. | Side-chain crystallizable polymers for medical applications |
US8702716B1 (en) | 2009-09-21 | 2014-04-22 | Reva Medical Inc. | Devices, compositions and methods for bone and tissue augmentation |
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