CA2559250A1 - X-ray visible drug delivery device - Google Patents
X-ray visible drug delivery device Download PDFInfo
- Publication number
- CA2559250A1 CA2559250A1 CA002559250A CA2559250A CA2559250A1 CA 2559250 A1 CA2559250 A1 CA 2559250A1 CA 002559250 A CA002559250 A CA 002559250A CA 2559250 A CA2559250 A CA 2559250A CA 2559250 A1 CA2559250 A1 CA 2559250A1
- Authority
- CA
- Canada
- Prior art keywords
- drug delivery
- delivery device
- ray visible
- visible drug
- radio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000012377 drug delivery Methods 0.000 title claims abstract 15
- 239000003433 contraceptive agent Substances 0.000 claims abstract 3
- 230000002254 contraceptive effect Effects 0.000 claims abstract 3
- 229920001169 thermoplastic Polymers 0.000 claims 6
- 239000000463 material Substances 0.000 claims 5
- RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 claims 4
- 229960004976 desogestrel Drugs 0.000 claims 4
- GCKFUYQCUCGESZ-BPIQYHPVSA-N etonogestrel Chemical compound O=C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 GCKFUYQCUCGESZ-BPIQYHPVSA-N 0.000 claims 4
- 239000007943 implant Substances 0.000 claims 3
- 229910052751 metal Inorganic materials 0.000 claims 3
- 239000002184 metal Substances 0.000 claims 3
- TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims 2
- 238000002657 hormone replacement therapy Methods 0.000 claims 2
- -1 polyethylene vinyl acetate Polymers 0.000 claims 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0404—X-ray contrast preparations containing barium sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/32—Antioestrogens
Abstract
The subject invention provides an X-ray visible drug delivery device for subdermal administration of a contraceptive or hormone remplacement therapy.
Claims (13)
1. An X-ray visible drug delivery device for subdermal administration of a contraceptive or hormone replacement therapy comprising one compartment consisting of (i) a thermoplastic polymer core loaded with (a) a contraceptively effective or therapeutically effective amount of desogestrel or 3-ketodesogestrel and (b) about 4-30% by weight radio-opaque material and (ii) a non-medicated thermoplastic polymer skin covering the core.
2. An X-ray visible drug delivery device according to claim 1 wherein the radio-opaque material is about 6-20% by weight
3. An X-ray visible drug delivery device according to claim 1 wherein the radio-opaque material is about 8-15% by weight.
4. An X-ray visible drug delivery device according to any one of the preceding claims wherein the radio-opaque material in the core does not affect the release of the desogestrel or 3-ketodesogestrel from the device.
5. An X-ray visible drug delivery device according to any one of the preceding claims wherein the radio-opaque particles do not migrate out of the implant.
6. An X-ray visible drug delivery device according to any one of the preceding claims wherein the radio-opaque material is barium sulphate.
7. An X-ray visible drug delivery device according to any one of the preceding claims wherein the device is an implant.
8. An X-ray visible drug delivery device according to any one of the preceding claims wherein the thermoplastic polymer is polyethylene vinyl acetate.
9. An X-ray visible drug delivery device for subdermal administration of a contraceptive or hormone replacement therapy comprising one compartment consisting of (i) a thermoplastic polymer core loaded with a contraceptively effective or therapeutically effective amount of desogestrel or 3-ketodesogestrel and containing an inert metal wire and (ii) a non-medicated thermoplastic polymer skin covering the core.
10. An X-ray visible drug delivery device according to claim 9 wherein the metal wire in the core does not affect the release of the desogestrel or 3-ketodesogestrel from the device.
11. An X-ray visible drug delivery device according to claims 9 or 10 wherein the inert metal wire is a titanium wire.
12. An X-ray visible drug delivery device according to any one of claims 9-11 wherein the device is an implant.
13. An X-ray visible drug delivery device according to any one of claims 9-12 wherein the thermoplastic polymer is polyethylene vinyl acetate.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04101151 | 2004-03-19 | ||
| EP04101151.1 | 2004-03-19 | ||
| PCT/EP2005/051150 WO2005089814A1 (en) | 2004-03-19 | 2005-03-14 | X-ray visible drug delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2559250A1 true CA2559250A1 (en) | 2005-09-29 |
| CA2559250C CA2559250C (en) | 2012-07-17 |
Family
ID=34928916
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2559250A Expired - Fee Related CA2559250C (en) | 2004-03-19 | 2005-03-14 | X-ray visible drug delivery device |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US8722037B2 (en) |
| EP (1) | EP1729819B1 (en) |
| JP (1) | JP5055501B2 (en) |
| KR (1) | KR101086619B1 (en) |
| CN (1) | CN1953770B (en) |
| AR (1) | AR048106A1 (en) |
| AT (1) | ATE399569T1 (en) |
| AU (1) | AU2005224054B2 (en) |
| BR (1) | BRPI0508865B8 (en) |
| CA (1) | CA2559250C (en) |
| CY (1) | CY1108362T1 (en) |
| DE (1) | DE602005007873D1 (en) |
| DK (1) | DK1729819T3 (en) |
| EC (1) | ECSP066865A (en) |
| EG (1) | EG24359A (en) |
| ES (1) | ES2308460T3 (en) |
| HK (1) | HK1096316A1 (en) |
| HR (1) | HRP20080414T3 (en) |
| IL (1) | IL177970A (en) |
| LV (1) | LV13521B (en) |
| MX (1) | MXPA06010714A (en) |
| MY (1) | MY142649A (en) |
| NO (1) | NO338191B1 (en) |
| NZ (1) | NZ549877A (en) |
| PE (1) | PE20060022A1 (en) |
| PL (1) | PL1729819T3 (en) |
| PT (1) | PT1729819E (en) |
| RU (1) | RU2384347C2 (en) |
| SI (1) | SI1729819T1 (en) |
| TW (1) | TWI434676B (en) |
| UA (1) | UA86404C2 (en) |
| WO (1) | WO2005089814A1 (en) |
| ZA (1) | ZA200607602B (en) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004026111A2 (en) | 2000-11-16 | 2004-04-01 | Microspherix Llc | Flexible and/or elastic brachytherapy seed or strand |
| TWI434676B (en) | 2004-03-19 | 2014-04-21 | Merck Sharp & Dohme | X-ray visible drug delivery device |
| CA2625264C (en) | 2005-10-13 | 2015-12-15 | Synthes (U.S.A.) | Drug-impregnated sleeve for a medical implant |
| TWI590843B (en) | 2011-12-28 | 2017-07-11 | 信迪思有限公司 | Films and methods of manufacture |
| CN105555328B (en) | 2013-06-21 | 2019-01-11 | 德普伊新特斯产品公司 | film and manufacturing method |
| AU2017263253B2 (en) * | 2016-05-12 | 2022-04-14 | Merck Sharp & Dohme Llc | Drug delivery system for the delivery of antiviral agents |
| USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
| USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
| US10406336B2 (en) | 2016-08-03 | 2019-09-10 | Neil S. Davey | Adjustable rate drug delivery implantable device |
| EP3518896A4 (en) | 2016-09-29 | 2020-08-05 | Gesea Biosciences Inc. | Bioerodible implant for long-term drug delivery and associated methods of manufacture and use |
| US20190008792A1 (en) * | 2017-07-08 | 2019-01-10 | Hera Health Solutions Inc. | Bioerodible drug delivery implants |
| SG11202005949UA (en) | 2018-05-24 | 2020-07-29 | Celanese Eva Performance Polymers Corp | Implantable device for sustained release of a macromolecular drug compound |
| SG11202005947RA (en) | 2018-05-24 | 2020-07-29 | Celanese Eva Performance Polymers Corp | Implantable device for sustained release of a macromolecular drug compound |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE8123912U1 (en) | 1981-08-17 | 1982-01-14 | B. Braun Melsungen Ag, 3508 Melsungen | PLASTIC PROBE |
| LU85320A1 (en) | 1984-04-17 | 1985-11-27 | Oreal | COSMETIC COMPOSITION CONTAINING ALOESIN AS A PROTECTIVE AGENT AGAINST SUNLIGHT AND ITS USE FOR PROTECTING SKIN AND HAIR |
| GB8430703D0 (en) | 1984-12-05 | 1985-01-16 | Lrc Products | Drug release devices |
| US4866132A (en) | 1986-04-17 | 1989-09-12 | The Research Foundation Of State University Of New York | Novel radiopaque barium polymer complexes, compositions of matter and articles prepared therefrom |
| ES2054784T3 (en) | 1987-08-08 | 1994-08-16 | Akzo Nv | A METHOD FOR THE MANUFACTURE OF AN IMPLANT. |
| EP0304107B1 (en) | 1987-08-18 | 1992-01-15 | Akzo N.V. | Implant injection device |
| JPH01178540A (en) | 1987-12-29 | 1989-07-14 | Mitsubishi Cable Ind Ltd | Composition for molding medical tube |
| US5141522A (en) * | 1990-02-06 | 1992-08-25 | American Cyanamid Company | Composite material having absorbable and non-absorbable components for use with mammalian tissue |
| DE4320754A1 (en) | 1993-06-23 | 1995-01-05 | Hoechst Ag | Device for applying implants |
| GB9401577D0 (en) | 1994-01-27 | 1994-03-23 | Sheffield Orthodontic Lab Limi | Polymer material suitable for the production of medical artifacts |
| US6162236A (en) * | 1994-07-11 | 2000-12-19 | Terumo Kabushiki Kaisha | Trocar needle and expandable trocar tube |
| AU5025096A (en) | 1995-02-27 | 1996-09-18 | Instent Inc. | Hollow stent |
| US6171326B1 (en) | 1998-08-27 | 2001-01-09 | Micrus Corporation | Three dimensional, low friction vasoocclusive coil, and method of manufacture |
| US6174329B1 (en) | 1996-08-22 | 2001-01-16 | Advanced Cardiovascular Systems, Inc. | Protective coating for a stent with intermediate radiopaque coating |
| WO1998058698A1 (en) | 1997-06-20 | 1998-12-30 | Akzo Nobel N.V. | Preloaded implantation device |
| US6174330B1 (en) | 1997-08-01 | 2001-01-16 | Schneider (Usa) Inc | Bioabsorbable marker having radiopaque constituents |
| ATE504561T1 (en) | 1997-11-07 | 2011-04-15 | Univ Rutgers | RADIO-DENSIVE POLYMERIC BIOMATERIALS |
| US6159165A (en) | 1997-12-05 | 2000-12-12 | Micrus Corporation | Three dimensional spherical micro-coils manufactured from radiopaque nickel-titanium microstrand |
| EP0938894A1 (en) | 1998-02-16 | 1999-09-01 | Biomat B.V. | Implantable radiopaque device and use thereof |
| US6171297B1 (en) | 1998-06-30 | 2001-01-09 | Schneider (Usa) Inc | Radiopaque catheter tip |
| DE29908415U1 (en) | 1999-05-18 | 1999-07-22 | Carl | Agents for the treatment of local periodontal infections |
| DE19946606B4 (en) * | 1999-09-29 | 2013-07-04 | Robert Bosch Gmbh | Apparatus for forming an air-fuel mixture for an internal combustion engine during a warm-up phase |
| CA2398832A1 (en) | 1999-11-09 | 2002-08-12 | Forschungszentrum Karlsruhe Gmbh | Mixture containing rare earths and use thereof |
| FR2803304B1 (en) * | 1999-12-29 | 2006-03-24 | Ceca Sa | INORGANIC DEPOSIT INHIBITORS, ESPECIALLY IN OIL WELLS |
| US6355058B1 (en) | 1999-12-30 | 2002-03-12 | Advanced Cardiovascular Systems, Inc. | Stent with radiopaque coating consisting of particles in a binder |
| DE10004832A1 (en) * | 2000-01-31 | 2001-08-16 | Ethicon Gmbh | Flat implant with X-ray visible elements |
| SE0000363L (en) | 2000-02-04 | 2001-08-05 | Zoucas Kirurgkonsult Ab | Coated medical device |
| FI20000572A (en) | 2000-03-13 | 2001-09-14 | Leiras Oy | Device intended for application of implants |
| DE10014518A1 (en) | 2000-03-23 | 2001-10-04 | Aventis Pharma Gmbh | Device for applying implants |
| ATE337804T1 (en) | 2000-11-21 | 2006-09-15 | Schering Ag | TUBULAR VESSEL IMPLANTS (STENTS) AND METHOD FOR THE PRODUCTION THEREOF |
| US20020138136A1 (en) | 2001-03-23 | 2002-09-26 | Scimed Life Systems, Inc. | Medical device having radio-opacification and barrier layers |
| JP4901021B2 (en) | 2001-06-06 | 2012-03-21 | 川澄化学工業株式会社 | Catheter tube |
| US6911219B2 (en) | 2001-09-27 | 2005-06-28 | Surgica Corporation | Partially acetalized polyvinyl alcohol embolization particles, compositions containing those particles and methods of making and using them |
| AUPR951501A0 (en) * | 2001-12-14 | 2002-01-24 | Smart Drug Systems Inc | Modified sustained release pharmaceutical system |
| US6887270B2 (en) * | 2002-02-08 | 2005-05-03 | Boston Scientific Scimed, Inc. | Implantable or insertable medical device resistant to microbial growth and biofilm formation |
| US8133501B2 (en) | 2002-02-08 | 2012-03-13 | Boston Scientific Scimed, Inc. | Implantable or insertable medical devices for controlled drug delivery |
| US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
| US7214206B2 (en) | 2003-04-03 | 2007-05-08 | Valera Pharmaceuticals, Inc. | Implanting device and method of using same |
| DE10355087A1 (en) | 2003-11-24 | 2005-06-09 | Basf Ag | Process for the electrochemical preparation of a crystalline porous organometallic framework |
| TWI434676B (en) | 2004-03-19 | 2014-04-21 | Merck Sharp & Dohme | X-ray visible drug delivery device |
| US8888745B2 (en) | 2005-01-24 | 2014-11-18 | Merck Sharp & Dohme B.V. | Applicator for inserting an implant |
| SI3417905T2 (en) | 2005-01-24 | 2023-11-30 | Merck Sharp & Dohme B.V. | Applicator for inserting an implant |
| USD551759S1 (en) | 2005-06-13 | 2007-09-25 | N. V. Organon | Applicator for inserting an implant |
| EP1984063B1 (en) | 2006-01-19 | 2019-08-14 | Merck Sharp & Dohme B.V. | Kit for and method of assembling an applicator for inserting an implant |
-
2005
- 2005-03-07 TW TW094106832A patent/TWI434676B/en active
- 2005-03-14 NZ NZ549877A patent/NZ549877A/en unknown
- 2005-03-14 ES ES05717030T patent/ES2308460T3/en active Active
- 2005-03-14 CA CA2559250A patent/CA2559250C/en not_active Expired - Fee Related
- 2005-03-14 US US10/592,725 patent/US8722037B2/en active Active
- 2005-03-14 EP EP05717030A patent/EP1729819B1/en active Active
- 2005-03-14 JP JP2007503338A patent/JP5055501B2/en active Active
- 2005-03-14 PT PT05717030T patent/PT1729819E/en unknown
- 2005-03-14 SI SI200530390T patent/SI1729819T1/en unknown
- 2005-03-14 DK DK05717030T patent/DK1729819T3/en active
- 2005-03-14 KR KR1020067021233A patent/KR101086619B1/en active IP Right Grant
- 2005-03-14 PL PL05717030T patent/PL1729819T3/en unknown
- 2005-03-14 MX MXPA06010714A patent/MXPA06010714A/en active IP Right Grant
- 2005-03-14 RU RU2006136913/15A patent/RU2384347C2/en active
- 2005-03-14 BR BRPI0508865A patent/BRPI0508865B8/en active IP Right Grant
- 2005-03-14 WO PCT/EP2005/051150 patent/WO2005089814A1/en active IP Right Grant
- 2005-03-14 DE DE602005007873T patent/DE602005007873D1/en active Active
- 2005-03-14 UA UAA200609906A patent/UA86404C2/en unknown
- 2005-03-14 CN CN2005800085085A patent/CN1953770B/en active Active
- 2005-03-14 AU AU2005224054A patent/AU2005224054B2/en active Active
- 2005-03-14 AT AT05717030T patent/ATE399569T1/en active
- 2005-03-17 MY MYPI20051159A patent/MY142649A/en unknown
- 2005-03-18 AR ARP050101064A patent/AR048106A1/en not_active Application Discontinuation
- 2005-03-18 PE PE2005000311A patent/PE20060022A1/en active IP Right Grant
-
2006
- 2006-09-07 IL IL177970A patent/IL177970A/en active IP Right Grant
- 2006-09-11 ZA ZA200607602A patent/ZA200607602B/en unknown
- 2006-09-17 EG EGNA2006000870 patent/EG24359A/en active
- 2006-09-19 EC EC2006006865A patent/ECSP066865A/en unknown
- 2006-10-17 LV LVP-06-117A patent/LV13521B/en unknown
- 2006-10-18 NO NO20064716A patent/NO338191B1/en unknown
-
2007
- 2007-04-18 HK HK07104069A patent/HK1096316A1/en unknown
-
2008
- 2008-08-26 HR HR20080414T patent/HRP20080414T3/en unknown
- 2008-09-23 CY CY20081101029T patent/CY1108362T1/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20200831 |
|
| MKLA | Lapsed |
Effective date: 20200330 |