CA2537648A1 - Compositions and methods for increasing muscle mass and strength, improving athletic performance, and/or reducing body fat mass leading to weight loss - Google Patents

Compositions and methods for increasing muscle mass and strength, improving athletic performance, and/or reducing body fat mass leading to weight loss Download PDF

Info

Publication number
CA2537648A1
CA2537648A1 CA002537648A CA2537648A CA2537648A1 CA 2537648 A1 CA2537648 A1 CA 2537648A1 CA 002537648 A CA002537648 A CA 002537648A CA 2537648 A CA2537648 A CA 2537648A CA 2537648 A1 CA2537648 A1 CA 2537648A1
Authority
CA
Canada
Prior art keywords
testosterone
extract
levels
red wine
proanthocyanidins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002537648A
Other languages
French (fr)
Inventor
Paul T. Gardiner
Marvin A. Heuer
Brad H. Pilon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RIPPED FORMULATIONS Ltd
Original Assignee
RIPPED FORMULATIONS LTD
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RIPPED FORMULATIONS LTD filed Critical RIPPED FORMULATIONS LTD
Publication of CA2537648A1 publication Critical patent/CA2537648A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/30Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537Salvia (sage)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/87Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/899Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

Methods and compositions for the inhibition of human aromatase enzyme are presented for the purposes of increasing or activating the total levels of testosterone, free testosterone, and/or luteinizing hormone levels, while decreasing the levels of estrogen and estradiol. The increase in testosterone levels, combined with a proper exercise and diet regime may lead to increased muscle mass and strength, improved athletic performance and recovery and lead to an increase in lean body mass. Red Wine extracts containing Proanthocyanidins are employed to inhibit the action of the human aromatase enzyme.

Description

Compositions and Methods for Increasing Muscle Mass and Strength, Improving Athletic Performance, andlor Reducing Body Fat Mass Leading to Weight Loss Field of the Invention The present invention concerns compositions and methods for inhibiting the human aromatase enzyme to increase or activate total testosterone, free testosterone, and/or luteinizing hormone levels, for the purposes of increasing muscle mass and strength, improving athletic performance and recovery therefrom, and/or reducing body fat mass leading to weight loss.
In a preferred embodiment, the present invention concerns the use of red wine and its extracts to inhibit the aromatase enzyme within the human body, resulting in an increase in, or activation of, total testosterone, free testosterone and/or luteinizing hormone levels while simultaneously achieving a reduction in estrogen and/or estradiol levels, for the purposes of increasing muscle mass and strength, improving athletic performance and recovery therefrom, and/or reducing body fat mass leading to weight loss.
Summary of the Invention The present invention, according to one embodiment thereof, concerns compositions and methods for inhibiting the human aromatase enzyme to increase or activate total testosterone, free testosterone, and/or luteinizing hormone levels, for the purposes of increasing muscle mass and strength, improving athletic performance and recovery therefrom, and/or reducing body fat mass leading to weight loss.
In a preferred embodiment, the present invention concerns the use of red wine and its extracts to inhibit the aromatase enzyme within the human body, resulting in an increase in or activation of total testosterone, free testosterone and/or luteinizing hormone levels while simultaneously achieving a reduction in estrogen and/or estradiol levels for the purposes of increasing muscle mass and strength, improving athletic performance and recovery therefrom, and/or reducing body fat mass leading to weight loss.
In addition or alternatively, the present invention provides, according to various embodiments thereof, compositions and methods for increasing muscle mass and strength, improving athletic performance and recovery therefrom, and/or reducing body fat mass leading to weight loss, by increasing or activating total testosterone, free testosterone and/or luteinizing hormone levels while simultaneously reducing estrogen and/or estradiol levels.
In addition or alternatively, the present invention provides, according to various embodiments thereof, compositions and methods for improving memory and lean muscle mass, positively affecting mood, and/or the prevention of sarcopenia and/or other disorders commonly associated with aging.
Detailed Description of the Invention The present invention, according to various embodiments thereof, provides compositions and methods for increasing muscle mass and strength, improving athletic performance and recovery therefrom, and/or reducing body fat mass leading to weight loss. More specifically, the present invention provides for the use of red wine and its extracts to inhibit the human aromatase enzyme, resulting in an increase in or activation of total testosterone, free testosterone, and/or luteinizing hormone levels and a simultaneous decrease in estrogen and/or estradiol levels for the purposes of increasing muscle mass and strength, improving athletic performance and recovery therefrom, and/or reducing body fat mass leading to weight loss.
As a metabolite of testosterone, within the testes, a percentage of testosterone is converted to estradiol via aromatization (Harper's Biochemistry 25t" ed. Murray et al., 2000, Appleton and Lange, Toronto). Aromatase is the enzyme responsible for the conversion of androgen substrates, such as testosterone into estrogens. Proanthocyanidins from red wine extracts been shown to inhibit the action of aromatase activity (Eng ET, et al. Cancer Res.

Dec 1;63(23):8516-22). Therefore, the actions of proanthocyanidins inhibiting the human aromatase enzyme inhibits the conversion of testosterone to estradiol, thus leading to increased levels of free testosterone within the body.
The use of red wine extracts to inhibit the production of estradiol has also been employed in treatment of breast cancers.
The compositions of the present invention comprise red wine and/or its extracts. Certain polyphenols found in red wine, particularly Pinot Noir, Merlot, and Cabernet Sauvignon, may inhibit the human aromatase enzyme in a dose dependent manner. According to one embodiment, the present invention may employ extracts from red grapes and white button mushroom phytochemicals, as well as extracts of Broussonetia Papyrifera. In contrast, white wine and its extracts do not contain all of the same compounds as red wine and do not appear to have the ability to decrease the activity of aromatase, thus the present invention may provide further and significant inhibition of aromatase enzyme.
Aromatase enzymes may catalyze estrogen biosynthesis. Inhibition of aromatase with pharmaceutical non-steroidal aromatase inhibitors in normal healthy men may cause an increase in, or activation of, total testosterone, free testosterone and/or luteinizing hormone, with a subsequent decrease in estrogen and/or estradiol for the purposes of increasing muscle mass and strength, improving athletic performance and recovery therefrom, and/or reducing body fat mass leading to weight loss.
Although the present invention is not to be limited by any theoretical explanation, it is believed that inhibition of aromatase is a primary factor that increases or activates testosterone levels while simultaneously decreasing estrogen levels, and that certain polyphenols found in red wine and its extracts may inhibit aromatase activity. (t is believed that red wine and/or its extracts have a similar ability to increase or activate total testosterone, free testosterone and luteinizing hormone, with a subsequent decrease in estrogen and estradiol. It is believed that the increased or activated testosterone and/or luteinizing hormone levels lead to improvements in muscle mass and strength, athletic performance and recovery therefrom, and reductions in body fat mass leading to weight loss.
According to the invention there is provided a composition for increasing muscle mass and strength, improving athletic performance and recovery therefrom, andlor reducing body fat mass leading to weight loss, the composition comprising red wine and/or its extract. Suitable red wines and extracts thereof include, but are not limited to, Pinot Noirs, Merlots, and Cabernet Sauvignons.
Preferably, the composition is in the nature of a dietary supplement.
The supplement compositions according to the present invention may be employed in methods for increasing muscle mass and strength, improving athletic performance and recovery therefrom, and/or reducing body fat mass leading to weight loss by causing an inhibition of aromatase activity. The compositions of the present invention are particularly advantageous for athletes and bodybuilders to enhance performance. The amount of the composition which is administered to the athlete may vary depending on the desired effect, the body weight and characteristics of the athlete, and the like. For example, in preferred embodiments, the subject compositions comprising red wine and/or its extracts are administered to the diet of the athlete or bodybuilder on a daily basis.
The ability to increase or activate total testosterone, free testosterone, and/or luteinizing hormone levels while simultaneously decreasing estradiol and/or estrogen levels may also be desired in individuals having relatively low testosterone levels, for example hypogonadal older men.
According to a further aspect of the invention there is provided a method for improving memory and lean muscle mass, positively effecting mood, and/or for the prevention of sarcopenia and other disorders commonly associated with aging. This is particularly desired, for example, by the aging male population in the prevention of disorders commonly associated with aging.
Example 1 provides, in accordance with one embodiment of the present invention, a continuous, 24 hour testosterone support formulation. In this embodiment, the formulation provides for two supplemental dietary compositions, e.g., a daytime supplemental dietary composition and a night-time supplemental dietary composition, although any number of formulations may be provided throughout the day. Advantageously, both the day-time and night-time formulations of the supplemental dietary composition may include at least Eurycoma Longifolia, Grape Skin Extract and Red Wine Extract to provide proanthocyanidins. In addition, the night-time formulation may also include a blend of Zinc, Magnesium and Vitamin B6. Also, the day-time formulation may include Tibulus terrestris supplying Saponins, Acetyl-L-Carnitine, Xanthinol Nicotinate and/or Clary Sage Extract, supplying Sclareolides.
This dual-action formulation provides for improved testosterone support throughout the day by maintaining healthy testosterone levels during the a.m.
and p.m. hours. It may do this by responding to male hormonal changes that occur naturally throughout the day. For example, in the morning, when testosterone levels are typically higher, the a.m. formulation helps reduce the conversion of testosterone to estrogen. Later in the day, when testosterone levels are typically reduced and are at their lowest levels, the p.m. formula works to increase testosterone levels. In this manner, testosterone levels may be maintained and supported more effectively throughout the day.
Although the following examples illustrate the practice of the present invention in some of its embodiments, the examples should not be construed as limiting the scope of the invention. Other embodiments will be apparent to one skilled in the art from consideration of the specification and examples.
EXAMPLES
Example 1 Ingredients (PM 2.710 Active Formula Formulation) glservingConstituents Ise rvi n ZMA Blend (Zinc, Mg, 2.400 0.0324*Zn 88.5609%

Vitamin B6) 0.490*Mg 0.01248*Vitamin Grape Skin Extract (stdØ050 0.01 1.8450%
to 20% Proanthoc anidins Proanthoc anidins Red Wine Extract (std. 0.250 0.0625 9.2251%
to 25% Proanthoc anidins) Proanthocyanidins Eurycoma Longifolia 0.010 0.3690%
(50:1 Extract from root Total 2.710 100%

Ingredients (AM 2.235 Active Formula Formulation g/servingConstituents /servin Tibulus terrestris from0.100 0.045 Saponins 4.4743%
whole lant 45% Sa onins Acet I-L-Carnitine 0.500 22.3714%

Grape Skin Extract (stdØ50 0.05 11 to 1857%

20% Proanthoc anidins Proanthocyanidins.

Red Wine Extract (std. 1.250 0.3125 55.9284%
to 25% Proanthoc anidins Proanthoc anidins Eurycoma Longifolia 0.010 0.4474%
(50:1 Extract from root Xanthinol Nicotinate 0.100 4.4743%

Clary Sage Extract from0.025 0.0025 1 1186%

Whole plant (10% Sclareolides .

Sclareolides Total 2.235 100%

In redient Iservin Exam le 2 Red Wine Extract 0.500 Exam to 3 Tribulus terrestris 0.100 Acet I-L-Carnitine 0.500 Grape Seed Extract 0.500 Red Wine Extract 1.250 Coleus Forskhoii 0.025 Eu coma Lon ifolia 0.020 Clary Sage Extract 10% ~ 0.025 Example 4 ZMA Blend 2.400 Gra a Seed Extract 0.500 Red Wine Extract 0.250 Eu coma Lon ifolia 0.020 Example 5 Creatine Monoh drate 3.000 Melatonin 0.030 Red Wine Extract 0.500 Exam le 6 Creatine Monoh drate 5.000 AI ha Li oic Acid 0.250 Red Wine Extract 0.250 Exam le 7 Red Wine Extract 0.050 Gra a skin Extract 0.050 Coenz me Q 10 0.025 Astaxanthin 0.025 P cno enol 0.005 N-Acetyl-C steine 0.012 Vitamin C 0.012 Exam le 8 Red Wine Extract 0.100 Whe Protein 20.000 Creatine Monohydrate 3.000 Exam le 9 Red Wine extract 0.150 Green Tea Extract 0.200 Caffeine 0.200 Exam le 10 Red wine Extract 0.400 Di-indole Methane 0.170 Chrysin 0.100 Coleus Forskholii 0.250 Example 11 Delta-4-1012-dimethyl-cyclopent-0.300 a-phenantrene-3617-trion Red Wine Extract 0.300

Claims (18)

1. ~A supplemental dietary composition for at least one of reducing the conversion of testosterone to estrogen, increasing luteinizing hormone levels, and increasing free testosterone levels, the composition comprising:
Eurycoma Longifolia;
Grape Skin Extract; and Red Wine Extract to provide proanthocyanidins.
2. ~The supplemental dietary composition of claim 1, wherein a day-time and a night-time formulation are provided separately.
3. ~The supplemental composition of claim 2, wherein the night-time formulation further comprises a blend of Zinc, Magnesium and Vitamin B6.
4. ~The supplemental composition of claim 2, wherein the daytime formulation further comprises Tibulus terrestris supplying Saponins.
5. ~The supplemental composition of claim 2, wherein the daytime formulation further comprises Acetyl-L-Carnitine.
6. ~The supplemental composition of claim 2, wherein the daytime formulation further comprises Xanthinol Nicotinate.
7. ~The supplemental composition of claim 2, wherein the daytime formulation further comprises Clary Sage Extract, supplying Sclareolides.
8. ~A method for at least one of reducing the conversion of testosterone to estrogen, increasing luteinizing hormone levels, and increasing free testosterone levels, the method comprising the steps of:
ingesting a night-time supplemental dietary composition that includes at least Eurycoma Longifolia, Grape Skin Extract and Red Wine Extract to provide proanthocyanidins.
9. ~A method for at least one of reducing the conversion of testosterone to estrogen, increasing luteinizing hormone levels, and increasing free testosterone levels, the method comprising the steps of:
ingesting a daytime supplemental dietary composition that includes at least Eurycoma Longifolia, Grape Skin Extract and Red Wine Extract to provide proanthocyanidins.
10. ~The method of claim 8, wherein the night-time formulation further comprises a blend of Zinc, Magnesium and Vitamin B6.
11. ~The method of claim 9, wherein the daytime formulation further comprises Tibulus terrestris supplying Saponins.
12. ~The method of claim 9, wherein the daytime formulation further comprises~
Acetyl-L-Carnitine.
13. ~The method of claim 9, wherein the daytime formulation further comprises Xanthinol Nicotinate.
14. ~The method of claim 9, wherein the daytime formulation further comprises Clary Sage Extract, supplying Sclareolides.
15. ~The method of claim 8, wherein the Eurycoma Longifolia, Grape Skin Extract and Red Wine Extract providing proanthocyanidins are present in an amount effective to at least one of reduce the conversion of~
testosterone to estrogen, increase luteinizing hormone levels and increase free testosterone levels.
16.~The method of claim 9, wherein the Eurycoma Longifolia, Grape Skin Extract and Red Wine Extract providing proanthocyanidins are present in an amount effective to at least one of reduce the conversion of testosterone to estrogen, increase luteinizing hormone levels and increase free testosterone levels.
17. ~A method for providing a continuous, 24 hour testosterone support formulation by at least one of reducing the conversion of testosterone to estrogen, increasing luteinizing hormone levels, and increasing free testosterone levels, the method comprising the steps of:

ingesting a daytime supplemental dietary composition that includes at least Eurycoma Longifolia, Grape Skin Extract and Red Wine Extract to provide proanthocyanidins.

ingesting a night-time supplemental dietary composition that includes at feast Eurycoma Longifolia, Grape Skin Extract and Red Wine Extract to provide proanthocyanidins.
18. ~A continuous, 24 hour testosterone support formulation comprising:

a daytime supplemental dietary composition that includes at least Eurycoma Longifolia, Grape Skin Extract and Red Wine Extract to provide proanthocyanidins.

a night-time supplemental dietary composition that includes at least Eurycoma Longifolia, Grape Skin Extract and Red Wine Extract to provide proanthocyanidins.
CA002537648A 2005-02-28 2006-02-24 Compositions and methods for increasing muscle mass and strength, improving athletic performance, and/or reducing body fat mass leading to weight loss Abandoned CA2537648A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65761505P 2005-02-28 2005-02-28
US60/657,615 2005-02-28

Publications (1)

Publication Number Publication Date
CA2537648A1 true CA2537648A1 (en) 2006-08-28

Family

ID=36938960

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002537648A Abandoned CA2537648A1 (en) 2005-02-28 2006-02-24 Compositions and methods for increasing muscle mass and strength, improving athletic performance, and/or reducing body fat mass leading to weight loss

Country Status (2)

Country Link
US (1) US20060193923A1 (en)
CA (1) CA2537648A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8613959B2 (en) * 2009-02-10 2013-12-24 Fhg Corporation Dietary supplements containing extracts of Nelumbo and processes of using same
US20090306031A1 (en) * 2009-08-07 2009-12-10 Kneller Bruce W 5alpha-ANDROSTANE-3,6,17-TRIONE (KNELLER'S TRIONE) AND METHODS OF USE THEREFOR
WO2011016814A1 (en) * 2009-08-07 2011-02-10 Kneller Bruce W 5α-ANDROSTANE-3,6,17-TRIONE (KNELLER'S TRIONE) AND METHODS OF USE THEREFOR
WO2012097061A1 (en) * 2011-01-13 2012-07-19 Abbott Laboratories Nutritional compositions and methods for improving skeletal muscle protein metabolism

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4647450A (en) * 1983-07-20 1987-03-03 Warner-Lambert Company Chewing gum compositions containing magnesium trisilicate absorbates
US4917913A (en) * 1989-09-29 1990-04-17 International Flavors & Fragrances Inc. Use of sclareolide in augmenting or enhancing the organoleptic properties of foodstuffs
US5945546A (en) * 1997-03-25 1999-08-31 Subbiah; Ven Purification of sclareolide
US6117429A (en) * 1997-08-11 2000-09-12 Weider Nutrition International, Inc Compositions and treatments for reducing potential unwanted side effects associated with long-term administration of androgenic testosterone precursors
US6534086B1 (en) * 2000-03-06 2003-03-18 Metagenics, Inc. Composition and method for treatment of inflammation and pain in mammals
US7132117B2 (en) * 2000-08-29 2006-11-07 Government Of Malaysia Bioactive fraction of Eurycoma longifolia
GB0026018D0 (en) * 2000-10-24 2000-12-13 Novartis Nutrition Ag New composition
US6790465B2 (en) * 2000-12-01 2004-09-14 Snore-Fix, Inc. Composition and method for treating snoring
KR100858768B1 (en) * 2001-06-21 2008-09-16 교와 핫꼬 고교 가부시끼가이샤 Process for Producing Plant Extract Containing Plant Powder
EP1304048B1 (en) * 2001-10-22 2004-09-22 Ivo Pera Composition to reduce or quit smoking addiction
US7670612B2 (en) * 2002-04-10 2010-03-02 Innercap Technologies, Inc. Multi-phase, multi-compartment capsular delivery apparatus and methods for using same
US20040001817A1 (en) * 2002-05-14 2004-01-01 Giampapa Vincent C. Anti-aging nutritional supplement
US20040146539A1 (en) * 2003-01-24 2004-07-29 Gupta Shyam K. Topical Nutraceutical Compositions with Selective Body Slimming and Tone Firming Antiaging Benefits

Also Published As

Publication number Publication date
US20060193923A1 (en) 2006-08-31

Similar Documents

Publication Publication Date Title
Borghi et al. Nutraceuticals with a clinically detectable blood pressure‐lowering effect: a review of available randomized clinical trials and their meta‐analyses
AU2011100294A4 (en) Formulations and treatments for trichology
JP5084512B2 (en) Antioxidant dietary supplement compositions and methods for maintaining healthy skin
EP2491938B1 (en) Formulations for well-being
US5547671A (en) Anti-intoxication composition
US20080254135A1 (en) Resveratrol-containing compositions for general health and vitality
JP6530362B2 (en) Skin cosmetics
US20030064937A1 (en) Composition for reducing appetite in mammals
JP2010106022A (en) Composition including medicine for decreasing cellulite and unaesthetic appearance associated with cellulite, and drug product including the composition
US11116747B2 (en) Compositions comprising proanthocyanidins and oenothein B
CA2537648A1 (en) Compositions and methods for increasing muscle mass and strength, improving athletic performance, and/or reducing body fat mass leading to weight loss
WO2011116220A2 (en) Oral supplement
US6551628B1 (en) Herbal intestinal tract cleanser
FR2908604A1 (en) Food supplement useful to prevent or fight against androgenic alopecia, hair loss, the hyperseborrhea, acne and hirsutism, comprises green tea extract, another plant extract comprising quercetin and zinc
WO2008138115A1 (en) Nutritional composition comprising l-carmtme fumarate, red wine extract and saw palmetto extract for maintaining skeletal muscle androgen receptivity
US10172826B2 (en) Composition and method to treat and alleviate symptoms of hot flashes in a female subject
WO2012063198A1 (en) Compositions for the prevention and treatment of erectile dysfunction and impotence and for improving sport performance
US11850451B2 (en) Cosmetic compositions and methods for improving skin conditions
EP1074254A3 (en) Use of plant polyphenols with vitamines for treating iron overload
Shahwan et al. Neuroprotective antioxidant effect of Portulaca quadrifida Linn. Leaves extract on immobilization stress-induced changes in rat's brain
CA2539229C (en) Oral compositions comprising vitis vinifera, gingko biloba and centella asiatica for the treatment of cellulite
CA3026026A1 (en) Nutritional supplements for increasing male testosterone levels
FR2898059A1 (en) Phytohormonal composition useful to prevent and fight against (pre)menopausal disorders e.g. hot flashes, night sweats, fatigability and mood and sleep disorders, comprises combination of herbal extracts rich in lignans and sage extract
KR101791574B1 (en) Pharmaceutical composition for preventing or treating female menopausal disorder comprising an extract of black rice aleurone layer
US20200179426A1 (en) Methods of use for oenothein a and b from epilobium species

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead

Effective date: 20140225