CA2527975A1 - Biodegradable stents comprising a shape memory polymeric material - Google Patents

Biodegradable stents comprising a shape memory polymeric material Download PDF

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Publication number
CA2527975A1
CA2527975A1 CA002527975A CA2527975A CA2527975A1 CA 2527975 A1 CA2527975 A1 CA 2527975A1 CA 002527975 A CA002527975 A CA 002527975A CA 2527975 A CA2527975 A CA 2527975A CA 2527975 A1 CA2527975 A1 CA 2527975A1
Authority
CA
Canada
Prior art keywords
stent
smp
balloon catheter
smp material
shape
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002527975A
Other languages
French (fr)
Other versions
CA2527975C (en
Inventor
Peter Simon
Andreas Lendlein
Birgit Schnitter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GKSS Forshungszentrum Geesthacht GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10357747A external-priority patent/DE10357747A1/en
Priority claimed from DE10357744A external-priority patent/DE10357744A1/en
Application filed by Individual filed Critical Individual
Publication of CA2527975A1 publication Critical patent/CA2527975A1/en
Application granted granted Critical
Publication of CA2527975C publication Critical patent/CA2527975C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/16—Materials with shape-memory or superelastic properties

Abstract

The present invention relates to a temporary stent made from biodegradable shape memory polymeric (SMP material) material for use in the non-vascular or vascular field. The SMP material comprises a covalent polymer network or an interpenetrating polymer network. The stent may be implanted in compressed form by means of minimal invasive surgery and takes its desired size at the location of use caused by the shape memory effect. The stent gradually resolves caused by biological degradation which makes further surgery for removing the stent dispensable. The invention also relates to a method for manufacturing the stent and a kit comprising the stent and a temperature-controlled balloon catheter with an optical fibre.

Claims (14)

1. Stent, comprising a biodegradable SMP material for use in the non-vascular or vascular field.
2. Stent as claimed in claim 1, wherein the stent comprises a basic structure of a biodegradable plastic material or a degradable material coated by SMP
material.
3. Stent as claimed in claim 2, wherein the degradable metal is a magnesium alloy, pure magnesium or a composite of magnesium or a magnesium alloy with biodegradable polymer.
4. Stent as claimed in one of the preceding claims, further comprising additional additives selected among x-ray contrast materials and medically effective compounds.
5. Stent as claimed in at least one of the preceding claims, wherein the SMP
material is selected among polymer networks, thermoplastic SMP materials, composite materials or blends.
6. Scent as claimed in at least one of the preceding claims, wherein the SMP
material is selected among SMP materials in which the SMP effect is induced thermally, is photo-induced and/or wherein the SMP material is biocompatible and/or haemocompatible and/or wherein the SMP material reveals a partite-free degradation behaviour.
7. Stent as claimed in claim 5, wherein the network includes caprolacton units and/or pentadecalacton units.
8. Stent as claimed in claim 7, wherein the network consists of cross linked caprolactonmacromonomers.
9. Stent as claimed in one of the preceding claims, wherein the stent additionally comprises a surface coating.
10. Stent as claimed in claim 9, wherein the surface coating is selected among the coatings that modify haemocompatibility.
11. Method of manufacturing a stent as claimed in one of the preceding claims, comprising the processing of the SMP material to a stent by extrusion methods, coating methods, metal casting methods or spinning and weaving methods.
12. Kit, comprising a stent as claimed in at least one of claims 1 to 10, and additionally a temperature-controlled balloon catheter and/or a balloon catheter with an optical fibre.
13. Method for the minimal invasive implantation of a stent, comprising the following steps:
- placing a stent as claimed in one of claims 1 to 10 onto a temperature-controlled balloon catheter or a balloon catheter with an optical fibre, wherein the SMP material has two shapes in the memory and wherein this material was programmed to two shapes, wherein the first shape, compared to the second shape, is a tubular shape with a larger diameter - Inserting the stent placed in this manner to the desired position, wherein the SMP material exists in its second shape, - heating the stent by inserting a heating medium into the catheter, or introduction of light (preferably UV light) of a suitable wavelength, - activating the SMP effect to bring the stent into the first shape, - removing the balloon catheter.
14. Method for the minimal invasion implantation of a sent, comprising the following steps:
- placing a stent according to one of claims 1 to 10 onto a temperature controlled balloon catheter or a balloon catheter having a an optical fiber, - inserting the stent placed in this manner to the desired position - heating the stent by inserting a heating medium into the catheter or introducing light (preferably UV light) of a suitable wavelength - activating the SMP effect to bring the stent into its permanent shape - removing the balloon catheter.
CA2527975A 2003-06-13 2004-06-09 Biodegradable stents comprising a shape memory polymeric material Expired - Fee Related CA2527975C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
DE10326778 2003-06-13
DE10326782.4 2003-06-13
DE10326782 2003-06-13
DE10326778.6 2003-06-13
DE10357747.5 2003-12-10
DE10357747A DE10357747A1 (en) 2003-06-13 2003-12-10 Stents for vascular or non-vascular applications by minimally invasive implantation include a biodegradable shape-memory polymer material
DE10357744A DE10357744A1 (en) 2003-06-13 2003-12-10 Stents for vascular or non-vascular applications by minimally invasive implantation include a biodegradable shape-memory polymer material
DE10357744.0 2003-12-10
PCT/EP2004/006261 WO2004110515A1 (en) 2003-06-13 2004-06-09 Biodegradable stents

Publications (2)

Publication Number Publication Date
CA2527975A1 true CA2527975A1 (en) 2004-12-23
CA2527975C CA2527975C (en) 2011-08-09

Family

ID=33556476

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2527975A Expired - Fee Related CA2527975C (en) 2003-06-13 2004-06-09 Biodegradable stents comprising a shape memory polymeric material

Country Status (5)

Country Link
US (1) US20060287710A1 (en)
EP (1) EP1633410B1 (en)
BR (1) BRPI0411431B8 (en)
CA (1) CA2527975C (en)
WO (1) WO2004110515A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007127318A2 (en) * 2006-04-25 2007-11-08 Surmodics, Inc. Hydrophilic shape memory insertable medical articles

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351421B2 (en) * 1996-11-05 2008-04-01 Hsing-Wen Sung Drug-eluting stent having collagen drug carrier chemically treated with genipin
US7794494B2 (en) 2002-10-11 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices
US7976936B2 (en) 2002-10-11 2011-07-12 University Of Connecticut Endoprostheses
WO2005044361A1 (en) 2003-11-07 2005-05-19 Merlin Md Pte Ltd Implantable medical devices with enhanced visibility, mechanical properties and biocompatibility
DE10361942A1 (en) 2003-12-24 2005-07-21 Restate Patent Ag Radioopaque marker for medical implants
EP1734897A4 (en) 2004-03-31 2010-12-22 Merlin Md Pte Ltd A method for treating aneurysms
US8715340B2 (en) 2004-03-31 2014-05-06 Merlin Md Pte Ltd. Endovascular device with membrane
SG133420A1 (en) * 2005-12-13 2007-07-30 Merlin Md Pte Ltd An endovascular device with membrane having permanently attached agents
US8500751B2 (en) 2004-03-31 2013-08-06 Merlin Md Pte Ltd Medical device
US8043361B2 (en) 2004-12-10 2011-10-25 Boston Scientific Scimed, Inc. Implantable medical devices, and methods of delivering the same
EP1681077A1 (en) * 2005-01-12 2006-07-19 Acrostak Corp. A positioning device and a procedure for treating the walls of a resection cavity
DE102005003188A1 (en) 2005-01-20 2006-07-27 Restate Patent Ag Medical implant made of an amorphous or nanocrystalline alloy
WO2006086304A1 (en) * 2005-02-08 2006-08-17 Wilson-Cook Medical Inc. Self contracting stent
CN100400114C (en) * 2005-04-30 2008-07-09 中国科学院金属研究所 Biomedicine implant material with controllable degrading rate and its application
US20070010736A1 (en) * 2005-05-19 2007-01-11 Biophan Technologies, Inc. Electromagnetic resonant circuit sleeve for implantable medical device
US8870940B2 (en) * 2005-07-25 2014-10-28 Medtronic, Inc. Endolumenal prosthesis
US20070038290A1 (en) * 2005-08-15 2007-02-15 Bin Huang Fiber reinforced composite stents
US20070061006A1 (en) * 2005-09-14 2007-03-15 Nathan Desatnik Methods of making shape memory films by chemical vapor deposition and shape memory devices made thereby
DE102005056532A1 (en) * 2005-11-28 2007-05-31 Mnemoscience Gmbh Method for removal of tubular tissue supports e.g. stents from human or animal hollow organs, involves heating of tissue support to temperature below transition temperature, till softening
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US20070224244A1 (en) * 2006-03-22 2007-09-27 Jan Weber Corrosion resistant coatings for biodegradable metallic implants
US20070225799A1 (en) * 2006-03-24 2007-09-27 Medtronic Vascular, Inc. Stent, intraluminal stent delivery system, and method of treating a vascular condition
WO2007136969A2 (en) * 2006-05-16 2007-11-29 Medtronic Vascular, Inc. Bioabsorbable magnesium-reinforced polymer stents
US7818084B2 (en) * 2006-06-16 2010-10-19 The Invention Science Fund, I, LLC Methods and systems for making a blood vessel sleeve
CN103131315A (en) 2006-07-25 2013-06-05 科洛普拉斯特公司 Coating composition
US20080033522A1 (en) * 2006-08-03 2008-02-07 Med Institute, Inc. Implantable Medical Device with Particulate Coating
US20080085946A1 (en) * 2006-08-14 2008-04-10 Mather Patrick T Photo-tailored shape memory article, method, and composition
JP2010503489A (en) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド Biodegradable endoprosthesis and method for producing the same
DE102006058755A1 (en) * 2006-12-08 2008-06-12 Gkss-Forschungszentrum Geesthacht Gmbh Process for the preparation of an alternating multiblock copolymer with shape memory
US20080177373A1 (en) 2007-01-19 2008-07-24 Elixir Medical Corporation Endoprosthesis structures having supporting features
US20130150943A1 (en) 2007-01-19 2013-06-13 Elixir Medical Corporation Biodegradable endoprostheses and methods for their fabrication
US8814930B2 (en) * 2007-01-19 2014-08-26 Elixir Medical Corporation Biodegradable endoprosthesis and methods for their fabrication
KR100838809B1 (en) * 2007-05-03 2008-06-17 성균관대학교산학협력단 Temperature and ph-sensitive block copolymer having excellent gel strength and method of making the same and injectable hydrogles using thereof
DE102007029672A1 (en) * 2007-06-27 2009-01-02 Lzh Laserzentrum Hannover E.V. Implant and method for its production
JP5426553B2 (en) 2007-09-12 2014-02-26 トランスルミナル テクノロジーズ リミテッド ライアビリティー カンパニー Closure device, placement device, and method of placing a closure device
US8876861B2 (en) 2007-09-12 2014-11-04 Transluminal Technologies, Inc. Closure device, deployment apparatus, and method of deploying a closure device
US9456816B2 (en) 2007-09-12 2016-10-04 Transluminal Technologies, Llc Closure device, deployment apparatus, and method of deploying a closure device
US20090240323A1 (en) * 2008-03-20 2009-09-24 Medtronic Vascular, Inc. Controlled Degradation of Magnesium Stents
US8298466B1 (en) 2008-06-27 2012-10-30 Abbott Cardiovascular Systems Inc. Method for fabricating medical devices with porous polymeric structures
US8262692B2 (en) 2008-09-05 2012-09-11 Merlin Md Pte Ltd Endovascular device
US20100249912A1 (en) * 2009-03-30 2010-09-30 Wilson-Cook Medical Inc. Intraluminal device with controlled biodegradation
US8668732B2 (en) 2010-03-23 2014-03-11 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
WO2012027573A2 (en) 2010-08-25 2012-03-01 University Of Massachusetts Biodegradable shape memory polymer
JP5981930B2 (en) 2010-11-09 2016-08-31 トランスルミナル テクノロジーズ リミテッド ライアビリティー カンパニー Specially designed magnesium-aluminum alloy and its use in medicine in hemodynamic environment
US8734703B2 (en) 2010-11-11 2014-05-27 Spirit Aerosystems, Inc. Methods and systems for fabricating composite parts using a SMP apparatus as a rigid lay-up tool and bladder
US9073240B2 (en) 2010-11-11 2015-07-07 Spirit Aerosystems, Inc. Reconfigurable shape memory polymer tooling supports
US8951375B2 (en) 2010-11-11 2015-02-10 Spirit Aerosystems, Inc. Methods and systems for co-bonding or co-curing composite parts using a rigid/malleable SMP apparatus
US8815145B2 (en) 2010-11-11 2014-08-26 Spirit Aerosystems, Inc. Methods and systems for fabricating composite stiffeners with a rigid/malleable SMP apparatus
ES2943709T3 (en) 2012-04-06 2023-06-15 Merlin Md Pte Ltd Devices to treat an aneurysm
US9566666B2 (en) 2013-03-13 2017-02-14 Abbott Cardiovascular Systems Inc. Short pulse laser machining of polymers enhanced with light absorbers for fabricating medical devices
US20160114077A1 (en) * 2013-05-31 2016-04-28 University Of Massachusetts Medical School Elastomeric and degradable polymer scaffolds and high-mineral content polymer composites, and in vivo applications thereof
US10532125B1 (en) 2013-06-27 2020-01-14 Vanderbilt University Shape memory polymers and methods of use
WO2015160501A1 (en) 2014-04-18 2015-10-22 Auburn University Particulate vaccine formulations for inducing innate and adaptive immunity
US10293044B2 (en) 2014-04-18 2019-05-21 Auburn University Particulate formulations for improving feed conversion rate in a subject
US9855156B2 (en) 2014-08-15 2018-01-02 Elixir Medical Corporation Biodegradable endoprostheses and methods of their fabrication
US9259339B1 (en) 2014-08-15 2016-02-16 Elixir Medical Corporation Biodegradable endoprostheses and methods of their fabrication
US9480588B2 (en) 2014-08-15 2016-11-01 Elixir Medical Corporation Biodegradable endoprostheses and methods of their fabrication
US9730819B2 (en) 2014-08-15 2017-08-15 Elixir Medical Corporation Biodegradable endoprostheses and methods of their fabrication
US10583199B2 (en) 2016-04-26 2020-03-10 Northwestern University Nanocarriers having surface conjugated peptides and uses thereof for sustained local release of drugs
US11622872B2 (en) 2016-05-16 2023-04-11 Elixir Medical Corporation Uncaging stent
CN113143536B (en) 2016-05-16 2022-08-30 万能医药公司 Opening support

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2561853B2 (en) * 1988-01-28 1996-12-11 株式会社ジェイ・エム・エス Shaped memory molded article and method of using the same
US5964744A (en) * 1993-01-04 1999-10-12 Menlo Care, Inc. Polymeric medical device systems having shape memory
US5849035A (en) * 1993-04-28 1998-12-15 Focal, Inc. Methods for intraluminal photothermoforming
US5716410A (en) * 1993-04-30 1998-02-10 Scimed Life Systems, Inc. Temporary stent and method of use
DE19731021A1 (en) * 1997-07-18 1999-01-21 Meyer Joerg In vivo degradable metallic implant
PL342996A1 (en) * 1998-02-23 2001-07-16 Mnemoscience Gmbh Shape memory polymers
HU222543B1 (en) * 1998-02-23 2003-08-28 Massachusetts Institute Of Technology Biodegradable shape memory polymers
DE59913189D1 (en) * 1998-06-25 2006-05-04 Biotronik Ag Implantable, bioabsorbable vessel wall support, in particular coronary stent
JP4889151B2 (en) * 1998-09-08 2012-03-07 株式会社 京都医療設計 Vascular stent
DE69822470T2 (en) * 1998-11-12 2005-01-20 Takiron Co. Ltd. Biodegradable absorbable shape memory material
US6348067B1 (en) * 1998-11-25 2002-02-19 Israel Aircraft Industries Ltd. Method and system with shape memory heating apparatus for temporarily supporting a tubular organ
US20020103526A1 (en) * 2000-12-15 2002-08-01 Tom Steinke Protective coating for stent
US7083642B2 (en) * 2000-12-22 2006-08-01 Avantec Vascular Corporation Delivery of therapeutic capable agents
US6872433B2 (en) * 2001-03-27 2005-03-29 The Regents Of The University Of California Shape memory alloy/shape memory polymer tools
US20030153971A1 (en) * 2002-02-14 2003-08-14 Chandru Chandrasekaran Metal reinforced biodegradable intraluminal stents
DE10217350C1 (en) * 2002-04-18 2003-12-18 Mnemoscience Gmbh polyesterurethanes
DE10217351B3 (en) * 2002-04-18 2004-02-12 Mnemoscience Gmbh Interpenetrating networks
DK1519713T3 (en) * 2002-07-10 2011-01-10 Geesthacht Gkss Forschung Active ingredient release systems based on biodegradable or biocompatible polymers with a shape memory effect
US7138477B2 (en) * 2002-08-27 2006-11-21 Acushnet Company Compositions for golf equipment
DE10253634A1 (en) * 2002-11-13 2004-05-27 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin endoprosthesis
EP1633281A1 (en) * 2003-06-13 2006-03-15 Mnemoscience GmbH Stents

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007127318A2 (en) * 2006-04-25 2007-11-08 Surmodics, Inc. Hydrophilic shape memory insertable medical articles
WO2007127318A3 (en) * 2006-04-25 2008-11-20 Surmodics Inc Hydrophilic shape memory insertable medical articles

Also Published As

Publication number Publication date
BRPI0411431A (en) 2006-07-25
EP1633410A1 (en) 2006-03-15
WO2004110515A1 (en) 2004-12-23
BRPI0411431B1 (en) 2018-12-26
US20060287710A1 (en) 2006-12-21
EP1633410B1 (en) 2017-05-17
CA2527975C (en) 2011-08-09
BRPI0411431B8 (en) 2021-06-22

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