CA2465800A1 - Instrument - Google Patents

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Publication number
CA2465800A1
CA2465800A1 CA002465800A CA2465800A CA2465800A1 CA 2465800 A1 CA2465800 A1 CA 2465800A1 CA 002465800 A CA002465800 A CA 002465800A CA 2465800 A CA2465800 A CA 2465800A CA 2465800 A1 CA2465800 A1 CA 2465800A1
Authority
CA
Canada
Prior art keywords
concentration
component
measurement
indicated
biological fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002465800A
Other languages
French (fr)
Other versions
CA2465800C (en
Inventor
Zindel Herbert Heller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2465800A1 publication Critical patent/CA2465800A1/en
Application granted granted Critical
Publication of CA2465800C publication Critical patent/CA2465800C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • G01N27/3274Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/14Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333Saccharide [e.g., DNA, etc.]
    • Y10T436/144444Glucose

Abstract

A method and apparatus for performing a first measurement on a biological fluid or control, which first measurement varies with both the concentration of a first component and at least one of the presence and concentration of a second component. The method and apparatus perform a second measurement on the biological fluid or control, which second measurement varies primarily only with the at least one of the presence and concentration of the second component to develop an indication of the at least one of the presence and concentration of the second component. The first and second measurements may be made sequentially or simultaneously. The method and apparatus then remove an amount representative of the indicated presence or concentration of the second component from the concentration of the first component indicated by the first measurement.
CA002465800A 2001-11-07 2002-11-07 Instrument Expired - Lifetime CA2465800C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/046,030 2001-11-07
US10/046,030 US7018843B2 (en) 2001-11-07 2001-11-07 Instrument
PCT/EP2002/012422 WO2003040728A2 (en) 2001-11-07 2002-11-07 Method and apparatus for the determination of glucose

Publications (2)

Publication Number Publication Date
CA2465800A1 true CA2465800A1 (en) 2003-05-15
CA2465800C CA2465800C (en) 2009-09-01

Family

ID=21941198

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002465800A Expired - Lifetime CA2465800C (en) 2001-11-07 2002-11-07 Instrument

Country Status (5)

Country Link
US (3) US7018843B2 (en)
EP (1) EP1456666B1 (en)
JP (2) JP4180518B2 (en)
CA (1) CA2465800C (en)
WO (1) WO2003040728A2 (en)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7494816B2 (en) * 1997-12-22 2009-02-24 Roche Diagnostic Operations, Inc. System and method for determining a temperature during analyte measurement
US7390667B2 (en) * 1997-12-22 2008-06-24 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC phase angle measurements
US8071384B2 (en) 1997-12-22 2011-12-06 Roche Diagnostics Operations, Inc. Control and calibration solutions and methods for their use
US7407811B2 (en) * 1997-12-22 2008-08-05 Roche Diagnostics Operations, Inc. System and method for analyte measurement using AC excitation
EP2889611B1 (en) * 1999-11-15 2019-09-04 PHC Holdings Corporation Biosensor and measurement apparatus.
EP1256798A4 (en) 2000-11-30 2009-05-20 Panasonic Corp Biosensor, measuring instrument for biosensor, and method of quantifying substrate
US7195923B2 (en) * 2001-01-31 2007-03-27 Scripps Laboratories, Inc. Ratiometric determination of glycated protein
US7018843B2 (en) * 2001-11-07 2006-03-28 Roche Diagnostics Operations, Inc. Instrument
US8148164B2 (en) 2003-06-20 2012-04-03 Roche Diagnostics Operations, Inc. System and method for determining the concentration of an analyte in a sample fluid
US7488601B2 (en) * 2003-06-20 2009-02-10 Roche Diagnostic Operations, Inc. System and method for determining an abused sensor during analyte measurement
CN100472210C (en) * 2003-12-04 2009-03-25 松下电器产业株式会社 Blood component measuring method, sensor used therefor, and measuring instrument
EP1707953B1 (en) * 2003-12-04 2015-07-01 Panasonic Healthcare Holdings Co., Ltd. Method of measuring hematocrit (Hct)
BRPI0507376A (en) 2004-02-06 2007-07-10 Bayer Healthcare Llc oxidizable species as an internal reference for biosensors and method of use
NZ550825A (en) * 2004-03-31 2009-01-31 Bayer Healthcare Llc Method and apparatus for implementing threshold based correction functions for biosensors
CA2559297C (en) 2004-04-19 2012-05-22 Matsushita Electric Industrial Co., Ltd. Method for measuring blood components and biosensor and measuring instrument for use therein
BRPI0510779A (en) * 2004-05-14 2007-11-20 Bayer Healthcare Llc methods for performing hematocrit adjustment in assays and devices for same
US7356366B2 (en) * 2004-08-02 2008-04-08 Cardiac Pacemakers, Inc. Device for monitoring fluid status
US7344626B2 (en) 2005-04-15 2008-03-18 Agamatrix, Inc. Method and apparatus for detection of abnormal traces during electrochemical analyte detection
US20070129618A1 (en) * 2005-06-20 2007-06-07 Daniel Goldberger Blood parameter testing system
CN103558284B (en) 2005-07-20 2017-04-12 安晟信医疗科技控股公司 Gated amperometry
CN101273266B (en) 2005-09-30 2012-08-22 拜尔健康护理有限责任公司 Gated voltammetry
WO2007119574A2 (en) * 2006-03-23 2007-10-25 Ajinomoto Co., Inc. A method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna
US8529751B2 (en) 2006-03-31 2013-09-10 Lifescan, Inc. Systems and methods for discriminating control solution from a physiological sample
TW200835737A (en) 2006-11-01 2008-09-01 Dow Global Technologies Inc Polyurethane compositions and articles prepared therefrom, and methods for making the same
US8101062B2 (en) * 2007-07-26 2012-01-24 Nipro Diagnostics, Inc. System and methods for determination of analyte concentration using time resolved amperometry
US8088272B2 (en) * 2007-07-26 2012-01-03 Nipro Diagnostics, Inc. System and methods for determination of analyte concentration using time resolved amperometry
US8778168B2 (en) * 2007-09-28 2014-07-15 Lifescan, Inc. Systems and methods of discriminating control solution from a physiological sample
WO2009076302A1 (en) 2007-12-10 2009-06-18 Bayer Healthcare Llc Control markers for auto-detection of control solution and methods of use
US8603768B2 (en) 2008-01-17 2013-12-10 Lifescan, Inc. System and method for measuring an analyte in a sample
WO2009093840A2 (en) * 2008-01-22 2009-07-30 Industry Foundation Of Chonnam National University Method and apparatus for estimating features of target materials by using kinetic change information
JP5427362B2 (en) * 2008-03-25 2014-02-26 テルモ株式会社 Method and apparatus for measuring hematocrit value or blood component concentration
US8551320B2 (en) 2008-06-09 2013-10-08 Lifescan, Inc. System and method for measuring an analyte in a sample
CN103760213B (en) 2008-07-10 2016-04-13 拜尔健康护理有限责任公司 There is the system and method for the working cycle of amperometry and volt-ampere analysis
GB0814238D0 (en) * 2008-08-04 2008-09-10 Oxford Biosensors Ltd Enhancement of electrochemical response
US8760178B2 (en) 2009-09-30 2014-06-24 Arkray, Inc. Method for measuring target component in erythrocyte-containing specimen
JP5350960B2 (en) * 2009-09-30 2013-11-27 アークレイ株式会社 Method for measuring target components in erythrocyte-containing samples
US8101065B2 (en) * 2009-12-30 2012-01-24 Lifescan, Inc. Systems, devices, and methods for improving accuracy of biosensors using fill time
US8877034B2 (en) 2009-12-30 2014-11-04 Lifescan, Inc. Systems, devices, and methods for measuring whole blood hematocrit based on initial fill velocity
US8932445B2 (en) 2010-09-30 2015-01-13 Cilag Gmbh International Systems and methods for improved stability of electrochemical sensors
US8617370B2 (en) 2010-09-30 2013-12-31 Cilag Gmbh International Systems and methods of discriminating between a control sample and a test fluid using capacitance
TWI470226B (en) * 2011-03-01 2015-01-21 Eps Bio Technology Corp Methods for compensating a blood glucose concentration
EP2607492A1 (en) * 2011-12-22 2013-06-26 Roche Diagniostics GmbH Method for determining the concentration of an analyte
US9903830B2 (en) 2011-12-29 2018-02-27 Lifescan Scotland Limited Accurate analyte measurements for electrochemical test strip based on sensed physical characteristic(s) of the sample containing the analyte
KR101727447B1 (en) 2013-03-15 2017-04-14 에프. 호프만-라 로슈 아게 Methods of scaling data used to construct biosensor algorithms as well as devices, apparatuses and systems incorporating the same
CN105247356B (en) 2013-03-15 2017-11-07 豪夫迈·罗氏有限公司 Use the method and the unit and system of merging methods described of the information of the recovery pulse in being measured from electrochemical analyte
JP6412027B2 (en) 2013-03-15 2018-10-24 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft Method for fail-safe electrochemical measurement of analyte and device, apparatus and system incorporating the same
CA2900572C (en) 2013-03-15 2018-02-13 F. Hoffmann-La Roche Ag Methods of detecting high antioxidant levels during electrochemical measurements and failsafing an analyte concentration therefrom as well as devices, apparatuses and systems incorporting the same
US9459231B2 (en) 2013-08-29 2016-10-04 Lifescan Scotland Limited Method and system to determine erroneous measurement signals during a test measurement sequence
US9243276B2 (en) 2013-08-29 2016-01-26 Lifescan Scotland Limited Method and system to determine hematocrit-insensitive glucose values in a fluid sample
TWI586333B (en) * 2013-09-06 2017-06-11 A blood volume detecting method and a detecting device using the same
US10809246B2 (en) * 2014-05-23 2020-10-20 Nova Biomedical Corporation Hemolysis detection method and system
WO2016073395A1 (en) 2014-11-03 2016-05-12 Roche Diabetes Care, Inc. Electrode arrangements for electrochemical test elements and methods of use thereof
TWI580958B (en) 2015-04-28 2017-05-01 財團法人工業技術研究院 Methods for measuring analyte concentration
TWI591330B (en) * 2016-06-06 2017-07-11 盛群半導體股份有限公司 Measuring Method Associated To Hematocrit For Whole Blood And Measuring Circuit Thereof
JP2019529935A (en) 2016-10-05 2019-10-17 エフ ホフマン−ラ ロッシュ アクチェン ゲゼルシャフト Detection reagents and electrode arrangements for multi-sample diagnostic test elements and methods of using them

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB973807A (en) 1959-12-24 1964-10-28 Yellow Springs Instr Improvements in instruments for determining characteristics of blood
US3648159A (en) 1970-03-11 1972-03-07 Us Air Force Portable, self-contained system for analyzing biological fluids or the like
US3770607A (en) 1970-04-07 1973-11-06 Secretary Glucose determination apparatus
CH559912A5 (en) 1971-09-09 1975-03-14 Hoffmann La Roche
US3925183A (en) 1972-06-16 1975-12-09 Energetics Science Gas detecting and quantitative measuring device
US3902970A (en) 1973-07-30 1975-09-02 Leeds & Northrup Co Flow-through amperometric measuring system and method
CH585907A5 (en) 1973-08-06 1977-03-15 Hoffmann La Roche
US3922598A (en) 1974-08-15 1975-11-25 Robert R Steuer Hematocrit measurements by electrical conductivity
US3937615A (en) 1974-12-17 1976-02-10 Leeds & Northrup Company Auto-ranging glucose measuring system
US4052596A (en) 1974-12-23 1977-10-04 Hycel, Inc. Automatic hematology analyzer
US4230537A (en) 1975-12-18 1980-10-28 Monsanto Company Discrete biochemical electrode system
US4040908A (en) 1976-03-12 1977-08-09 Children's Hospital Medical Center Polarographic analysis of cholesterol and other macromolecular substances
US4123701A (en) 1976-07-01 1978-10-31 United States Surgical Corporation Disposable sample card having a well with electrodes for testing a liquid sample
US4127448A (en) 1977-02-28 1978-11-28 Schick Karl G Amperometric-non-enzymatic method of determining sugars and other polyhydroxy compounds
JPS5912135B2 (en) 1977-09-28 1984-03-21 松下電器産業株式会社 enzyme electrode
JPS5460996A (en) 1977-10-22 1979-05-16 Mitsubishi Chem Ind Method of measuring amount of sugar
US4214968A (en) 1978-04-05 1980-07-29 Eastman Kodak Company Ion-selective electrode
DE2817363C2 (en) 1978-04-20 1984-01-26 Siemens AG, 1000 Berlin und 8000 München Method for determining the concentration of sugar and a suitable electrocatalytic sugar sensor
DE2823485C2 (en) 1978-05-30 1986-03-27 Albert Prof. Dr. 3550 Marburg Huch Trough electrode
US4240027A (en) 1978-08-31 1980-12-16 The United States Of America As Represented By The Secretary Of The Army Electromagnetic method for the noninvasive analysis of cell membrane physiology and pharmacology
US4225410A (en) 1978-12-04 1980-09-30 Technicon Instruments Corporation Integrated array of electrochemical sensors
US4273134A (en) 1979-05-22 1981-06-16 Biochem International Inc. Fixation ring assembly and method of assembling a sensor head
US4265250A (en) 1979-07-23 1981-05-05 Battle Research And Development Associates Electrode
US4263343A (en) 1979-08-13 1981-04-21 Eastman Kodak Company Reference elements for ion-selective membrane electrodes
US4301414A (en) 1979-10-29 1981-11-17 United States Surgical Corporation Disposable sample card and method of making same
US4301412A (en) 1979-10-29 1981-11-17 United States Surgical Corporation Liquid conductivity measuring system and sample cards therefor
US4303887A (en) 1979-10-29 1981-12-01 United States Surgical Corporation Electrical liquid conductivity measuring system
DE3029579C2 (en) 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Method and means for separating plasma or serum from whole blood
US4816224A (en) 1980-08-05 1989-03-28 Boehringer Mannheim Gmbh Device for separating plasma or serum from whole blood and analyzing the same
US4407959A (en) 1980-10-29 1983-10-04 Fuji Electric Co., Ltd. Blood sugar analyzing apparatus
US4413628A (en) 1980-11-19 1983-11-08 Tamulis Walter G pH Monitor electrode electrolyte cartridge
US4420564A (en) 1980-11-21 1983-12-13 Fuji Electric Company, Ltd. Blood sugar analyzer having fixed enzyme membrane sensor
DE3047782A1 (en) 1980-12-18 1982-07-08 Drägerwerk AG, 2400 Lübeck CIRCUIT FOR THE CORRECTION OF THE SENSOR OUTPUT SIZE
US4436094A (en) 1981-03-09 1984-03-13 Evreka, Inc. Monitor for continuous in vivo measurement of glucose concentration
AT369254B (en) 1981-05-07 1982-12-27 Otto Dipl Ing Dr Tech Prohaska MEDICAL PROBE
US4440175A (en) 1981-08-10 1984-04-03 University Patents, Inc. Membrane electrode for non-ionic species
US4431004A (en) 1981-10-27 1984-02-14 Bessman Samuel P Implantable glucose sensor
DE3202067C2 (en) 1982-01-23 1984-06-20 Holger Dr. 5100 Aachen Kiesewetter Device for determining the hematocrit value
JPS5913948A (en) * 1982-07-15 1984-01-24 Shimadzu Corp Electrostatic capacity type measuring apparatus of hematocrit
DE3228542A1 (en) 1982-07-30 1984-02-02 Siemens AG, 1000 Berlin und 8000 München METHOD FOR DETERMINING THE CONCENTRATION OF ELECTROCHEMICALLY IMPLEMENTABLE SUBSTANCES
DE3228551A1 (en) 1982-07-30 1984-02-02 Siemens AG, 1000 Berlin und 8000 München METHOD FOR DETERMINING SUGAR CONCENTRATION
US4679562A (en) 1983-02-16 1987-07-14 Cardiac Pacemakers, Inc. Glucose sensor
US5509410A (en) 1983-06-06 1996-04-23 Medisense, Inc. Strip electrode including screen printing of a single layer
CA1219040A (en) 1983-05-05 1987-03-10 Elliot V. Plotkin Measurement of enzyme-catalysed reactions
US4517291A (en) 1983-08-15 1985-05-14 E. I. Du Pont De Nemours And Company Biological detection process using polymer-coated electrodes
SE8305704D0 (en) 1983-10-18 1983-10-18 Leo Ab Cuvette
US4820399A (en) 1984-08-31 1989-04-11 Shimadzu Corporation Enzyme electrodes
US4671288A (en) 1985-06-13 1987-06-09 The Regents Of The University Of California Electrochemical cell sensor for continuous short-term use in tissues and blood
WO1986007632A1 (en) 1985-06-21 1986-12-31 Matsushita Electric Industrial Co., Ltd. Biosensor and method of manufacturing same
US4938860A (en) 1985-06-28 1990-07-03 Miles Inc. Electrode for electrochemical sensors
US4734184A (en) 1985-08-29 1988-03-29 Diamond Sensor Systems, Inc. Self-activating hydratable solid-state electrode apparatus
US4805624A (en) 1985-09-09 1989-02-21 The Montefiore Hospital Association Of Western Pa Low-potential electrochemical redox sensors
EP0215669A3 (en) 1985-09-17 1989-08-30 Seiko Instruments Inc. Analytical device and method for analysis of biochemicals, microbes and cells
US4935106A (en) 1985-11-15 1990-06-19 Smithkline Diagnostics, Inc. Ion selective/enzymatic electrode medical analyzer device and method of use
GB8608700D0 (en) 1986-04-10 1986-05-14 Genetics Int Inc Measurement of electroactive species in solution
US4795542A (en) 1986-04-24 1989-01-03 St. Jude Medical, Inc. Electrochemical concentration detector device
US4703756A (en) 1986-05-06 1987-11-03 The Regents Of The University Of California Complete glucose monitoring system with an implantable, telemetered sensor module
GB8612861D0 (en) 1986-05-27 1986-07-02 Cambridge Life Sciences Immobilised enzyme biosensors
US4750496A (en) 1987-01-28 1988-06-14 Xienta, Inc. Method and apparatus for measuring blood glucose concentration
JPS636451A (en) 1986-06-27 1988-01-12 Terumo Corp Enzyme sensor
GB8618022D0 (en) 1986-07-23 1986-08-28 Unilever Plc Electrochemical measurements
US4935346A (en) * 1986-08-13 1990-06-19 Lifescan, Inc. Minimum procedure system for the determination of analytes
US4894137A (en) 1986-09-12 1990-01-16 Omron Tateisi Electronics Co. Enzyme electrode
JPS63111453A (en) 1986-10-29 1988-05-16 Omron Tateisi Electronics Co Enzyme electrode
US4897162A (en) 1986-11-14 1990-01-30 The Cleveland Clinic Foundation Pulse voltammetry
US4759828A (en) 1987-04-09 1988-07-26 Nova Biomedical Corporation Glucose electrode and method of determining glucose
US4975647A (en) 1987-06-01 1990-12-04 Nova Biomedical Corporation Controlling machine operation with respect to consumable accessory units
US5160980A (en) 1987-07-27 1992-11-03 Boehringer Mannheim Corp. Test piece coloration comparative decision unit
US4940945A (en) 1987-11-02 1990-07-10 Biologix Inc. Interface circuit for use in a portable blood chemistry measuring apparatus
AU601635B2 (en) 1987-11-09 1990-09-13 Boehringer Mannheim Corporation Test sample color comparison device
US5128015A (en) 1988-03-15 1992-07-07 Tall Oak Ventures Method and apparatus for amperometric diagnostic analysis
US5108564A (en) 1988-03-15 1992-04-28 Tall Oak Ventures Method and apparatus for amperometric diagnostic analysis
US4871258A (en) 1988-04-29 1989-10-03 Boehringer Mannheim Corporation Color test meter
US5053199A (en) 1989-02-21 1991-10-01 Boehringer Mannheim Corporation Electronically readable information carrier
US5269891A (en) 1989-03-09 1993-12-14 Novo Nordisk A/S Method and apparatus for determination of a constituent in a fluid
US5312762A (en) 1989-03-13 1994-05-17 Guiseppi Elie Anthony Method of measuring an analyte by measuring electrical resistance of a polymer film reacting with the analyte
GB8927377D0 (en) 1989-12-04 1990-01-31 Univ Edinburgh Improvements in and relating to amperometric assays
US5508171A (en) 1989-12-15 1996-04-16 Boehringer Mannheim Corporation Assay method with enzyme electrode system
US4999632A (en) 1989-12-15 1991-03-12 Boehringer Mannheim Corporation Analog to digital conversion with noise reduction
WO1991009139A1 (en) 1989-12-15 1991-06-27 Boehringer Mannheim Corporation Redox mediator reagent and biosensor
US5243516A (en) 1989-12-15 1993-09-07 Boehringer Mannheim Corporation Biosensing instrument and method
US4999582A (en) 1989-12-15 1991-03-12 Boehringer Mannheim Corp. Biosensor electrode excitation circuit
JPH0820412B2 (en) 1990-07-20 1996-03-04 松下電器産業株式会社 Quantitative analysis method and device using disposable sensor
EP0576536B1 (en) 1991-02-27 2001-12-12 Roche Diagnostics Corporation Method of communicating with microcomputer controlled instruments
US5246858A (en) 1991-02-27 1993-09-21 Boehringer Mannheim Corporation Apparatus and method for analyzing a body fluid
US5232668A (en) 1991-02-27 1993-08-03 Boehringer Mannheim Corporation Test strip holding and reading mechanism for a meter
WO1992015859A1 (en) 1991-02-27 1992-09-17 Boehringer Mannheim Corporation Apparatus and method for analyzing body fluids
US5264103A (en) 1991-10-18 1993-11-23 Matsushita Electric Industrial Co., Ltd. Biosensor and a method for measuring a concentration of a substrate in a sample
JPH05297039A (en) * 1992-04-10 1993-11-12 M Jones Sado Method and apparatus for detecting variation of capacitance using computer
US5387327A (en) 1992-10-19 1995-02-07 Duquesne University Of The Holy Ghost Implantable non-enzymatic electrochemical glucose sensor
US5371687A (en) 1992-11-20 1994-12-06 Boehringer Mannheim Corporation Glucose test data acquisition and management system
FR2701117B1 (en) 1993-02-04 1995-03-10 Asulab Sa Electrochemical measurement system with multizone sensor, and its application to glucose measurement.
US5385846A (en) 1993-06-03 1995-01-31 Boehringer Mannheim Corporation Biosensor and method for hematocrit determination
DE9422380U1 (en) * 1993-06-08 2000-12-14 Roche Diagnostics Corp Biosensor measuring device with error protection procedures to avoid incorrect displays
US5352351A (en) 1993-06-08 1994-10-04 Boehringer Mannheim Corporation Biosensing meter with fail/safe procedures to prevent erroneous indications
US5366609A (en) 1993-06-08 1994-11-22 Boehringer Mannheim Corporation Biosensing meter with pluggable memory key
US5508203A (en) 1993-08-06 1996-04-16 Fuller; Milton E. Apparatus and method for radio frequency spectroscopy using spectral analysis
JP3322726B2 (en) * 1993-08-17 2002-09-09 長野計器株式会社 Capacitance detection circuit
US5841023A (en) 1993-08-31 1998-11-24 Boehringer Mannheim Corporation Magnet for medical instrument
CA2168966C (en) 1993-08-31 2007-07-31 George R. Lennert Analog heater control for medical instrument
JPH09502119A (en) 1993-08-31 1997-03-04 ベーリンガー・マンハイム・コーポレーション Power supply monitoring and control device for medical equipment
US5522255A (en) 1993-08-31 1996-06-04 Boehringer Mannheim Corporation Fluid dose, flow and coagulation sensor for medical instrument
US6153069A (en) 1995-02-09 2000-11-28 Tall Oak Ventures Apparatus for amperometric Diagnostic analysis
AUPN661995A0 (en) 1995-11-16 1995-12-07 Memtec America Corporation Electrochemical cell 2
US6121050A (en) * 1997-08-29 2000-09-19 Han; Chi-Neng Arthur Analyte detection systems
US5997817A (en) 1997-12-05 1999-12-07 Roche Diagnostics Corporation Electrochemical biosensor test strip
BR9814386B1 (en) * 1997-12-22 2009-08-11 apparatus and methods for determining the concentration of a medically significant component of a biological fluid.
JP3848993B2 (en) * 1998-01-06 2006-11-22 アークレイ株式会社 Method and apparatus for measuring the amount of components in the presence of coexisting substances
WO1999060391A1 (en) * 1998-05-20 1999-11-25 Arkray, Inc. Method and apparatus for electrochemical measurement using statistical technique
US6475372B1 (en) * 2000-02-02 2002-11-05 Lifescan, Inc. Electrochemical methods and devices for use in the determination of hematocrit corrected analyte concentrations
US6287451B1 (en) * 1999-06-02 2001-09-11 Handani Winarta Disposable sensor and method of making
US7018843B2 (en) * 2001-11-07 2006-03-28 Roche Diagnostics Operations, Inc. Instrument

Also Published As

Publication number Publication date
CA2465800C (en) 2009-09-01
JP4180518B2 (en) 2008-11-12
US20080293082A1 (en) 2008-11-27
EP1456666B1 (en) 2012-07-18
US7923258B2 (en) 2011-04-12
US7018843B2 (en) 2006-03-28
JP2005509161A (en) 2005-04-07
US7927882B2 (en) 2011-04-19
EP1456666A2 (en) 2004-09-15
US20060035384A1 (en) 2006-02-16
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WO2003040728A2 (en) 2003-05-15
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JP2008046141A (en) 2008-02-28
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