CA2425816A1 - Interpenetrating networks - Google Patents

Interpenetrating networks Download PDF

Info

Publication number
CA2425816A1
CA2425816A1 CA002425816A CA2425816A CA2425816A1 CA 2425816 A1 CA2425816 A1 CA 2425816A1 CA 002425816 A CA002425816 A CA 002425816A CA 2425816 A CA2425816 A CA 2425816A CA 2425816 A1 CA2425816 A1 CA 2425816A1
Authority
CA
Canada
Prior art keywords
materials
present
interpenetrating networks
implants
inter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002425816A
Other languages
French (fr)
Other versions
CA2425816C (en
Inventor
Andreas Lendlein
Annette Schmidt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GKSS Forshungszentrum Geesthacht GmbH
Original Assignee
MnemoScience GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by MnemoScience GmbH filed Critical MnemoScience GmbH
Publication of CA2425816A1 publication Critical patent/CA2425816A1/en
Application granted granted Critical
Publication of CA2425816C publication Critical patent/CA2425816C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40High-molecular-weight compounds
    • C08G18/42Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269Lactones
    • C08G18/4277Caprolactone and/or substituted caprolactone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/18Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00Polymeric products of isocyanates or isothiocyanates
    • C08G18/06Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40High-molecular-weight compounds
    • C08G18/42Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269Lactones
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/06Unsaturated polyesters
    • C08L67/07Unsaturated polyesters having terminal carbon-to-carbon unsaturated bonds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2270/00Compositions for creating interpenetrating networks
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2280/00Compositions for creating shape memory
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/04Polyurethanes
    • C08L75/06Polyurethanes from polyesters

Abstract

The present invention relates to the penetrating networks comprising a covalently crosslinked polymer component and a polyester urethane component. The materials in accordance with the present invention are suitable in particular as materials for medicinal purposes, as implants, for the target controlled stimuli-sensitive drug release, as ligament augmentation and as replacement material for inter- vertebrae disks.
CA002425816A 2002-04-18 2003-04-17 Interpenetrating networks Expired - Fee Related CA2425816C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10217351A DE10217351B3 (en) 2002-04-18 2002-04-18 Interpenetrating networks
DE10217351.6 2002-04-18

Publications (2)

Publication Number Publication Date
CA2425816A1 true CA2425816A1 (en) 2003-10-18
CA2425816C CA2425816C (en) 2007-11-20

Family

ID=29264772

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002425816A Expired - Fee Related CA2425816C (en) 2002-04-18 2003-04-17 Interpenetrating networks

Country Status (6)

Country Link
US (1) US7037984B2 (en)
EP (1) EP1362879B1 (en)
AT (1) ATE391145T1 (en)
CA (1) CA2425816C (en)
DE (2) DE10217351B3 (en)
ES (1) ES2303877T3 (en)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8795332B2 (en) 2002-09-30 2014-08-05 Ethicon, Inc. Barbed sutures
US6241747B1 (en) 1993-05-03 2001-06-05 Quill Medical, Inc. Barbed Bodily tissue connector
US5931855A (en) 1997-05-21 1999-08-03 Frank Hoffman Surgical methods using one-way suture
US7056331B2 (en) 2001-06-29 2006-06-06 Quill Medical, Inc. Suture method
US6848152B2 (en) 2001-08-31 2005-02-01 Quill Medical, Inc. Method of forming barbs on a suture and apparatus for performing same
US20040030062A1 (en) * 2002-05-02 2004-02-12 Mather Patrick T. Castable shape memory polymers
US6773450B2 (en) 2002-08-09 2004-08-10 Quill Medical, Inc. Suture anchor and method
US20040088003A1 (en) 2002-09-30 2004-05-06 Leung Jeffrey C. Barbed suture in combination with surgical needle
US8100940B2 (en) 2002-09-30 2012-01-24 Quill Medical, Inc. Barb configurations for barbed sutures
US7976936B2 (en) * 2002-10-11 2011-07-12 University Of Connecticut Endoprostheses
AU2003300377B2 (en) * 2002-10-11 2009-04-02 University Of Connecticut Blends of amorphous and semicrystalline polymers having shape memory properties
US7524914B2 (en) * 2002-10-11 2009-04-28 The University Of Connecticut Shape memory polymers based on semicrystalline thermoplastic polyurethanes bearing nanostructured hard segments
DE60336158D1 (en) * 2002-10-11 2011-04-07 Univ Connecticut ON SEMICRISTALLINE THERMOPLASTIC POLYURETHANES BASED FOR NANOSTRUCTURED HARD SEGMENTS BASED FORM MEMORY PILARMERS
US7794494B2 (en) * 2002-10-11 2010-09-14 Boston Scientific Scimed, Inc. Implantable medical devices
EP1560881B1 (en) * 2002-10-11 2011-11-23 University of Connecticut Crosslinked polycyclooctene
DE10300271A1 (en) * 2003-01-08 2004-07-22 Mnemoscience Gmbh Photosensitive polymer networks
US7624487B2 (en) 2003-05-13 2009-12-01 Quill Medical, Inc. Apparatus and method for forming barbs on a suture
BRPI0411431B8 (en) * 2003-06-13 2021-06-22 Gkss Forschungszentrum Geesthacht Gmbh biodegradable stents
SG164370A1 (en) 2004-05-14 2010-09-29 Quill Medical Inc Suture methods and devices
US20090088846A1 (en) 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
EP1844097A2 (en) * 2004-12-10 2007-10-17 University of Connecticut Shape memory polymer orthodontic appliances, and methods of making and using the same
US8043361B2 (en) * 2004-12-10 2011-10-25 Boston Scientific Scimed, Inc. Implantable medical devices, and methods of delivering the same
AU2006232116A1 (en) * 2005-04-01 2006-10-12 The Regents Of The University Of Colorado A graft fixation device and method
EP1801140A1 (en) 2005-12-22 2007-06-27 Mnemoscience GmbH Macro-diacrylate
DE102006012169B4 (en) * 2006-03-14 2007-12-13 Gkss-Forschungszentrum Geesthacht Gmbh Shape memory polymer with polyester and polyether segments, process for its preparation and shape programming and use
DE102006017759A1 (en) 2006-04-12 2007-10-18 Gkss-Forschungszentrum Geesthacht Gmbh Shape memory polymer with polyester and polyacrylic segments and methods for its preparation and programming
EP3009477B1 (en) 2006-07-20 2024-01-24 Orbusneich Medical Pte. Ltd Bioabsorbable polymeric composition for a medical device
US20080085946A1 (en) * 2006-08-14 2008-04-10 Mather Patrick T Photo-tailored shape memory article, method, and composition
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
EP2073754A4 (en) 2006-10-20 2012-09-26 Orbusneich Medical Inc Bioabsorbable polymeric composition and medical device background
DE102007010564A1 (en) 2007-02-22 2008-08-28 Gkss-Forschungszentrum Geesthacht Gmbh Method for one-step programming of three-molded plastics
US20080236601A1 (en) * 2007-03-28 2008-10-02 Medshape Solutions, Inc. Manufacturing shape memory polymers based on deformability peak of polymer network
US20080255612A1 (en) 2007-04-13 2008-10-16 Angiotech Pharmaceuticals, Inc. Self-retaining systems for surgical procedures
WO2009042841A2 (en) 2007-09-27 2009-04-02 Angiotech Pharmaceuticals, Inc. Self-retaining sutures including tissue retainers having improved strength
US7923486B2 (en) * 2007-10-04 2011-04-12 Board Of Regents, The University Of Texas System Bio-polymer and scaffold-sheet method for tissue engineering
US8916077B1 (en) 2007-12-19 2014-12-23 Ethicon, Inc. Self-retaining sutures with retainers formed from molten material
EP2222233B1 (en) 2007-12-19 2020-03-25 Ethicon, LLC Self-retaining sutures with heat-contact mediated retainers
US8118834B1 (en) 2007-12-20 2012-02-21 Angiotech Pharmaceuticals, Inc. Composite self-retaining sutures and method
EP2075273A1 (en) * 2007-12-28 2009-07-01 Mnemoscience GmbH Multiple shape memory polymer networks
EP2075272A1 (en) 2007-12-28 2009-07-01 Mnemoscience GmbH Shape memory polymer networks from crosslinkable thermoplasts
EP2075279A1 (en) 2007-12-28 2009-07-01 Mnemoscience GmbH Production of shape memory polymer articles by molding processes
DE102008004574A1 (en) * 2008-01-09 2009-07-16 Aesculap Ag Surgical suture with anchoring elements
US8615856B1 (en) 2008-01-30 2013-12-31 Ethicon, Inc. Apparatus and method for forming self-retaining sutures
ES2602570T3 (en) 2008-01-30 2017-02-21 Ethicon Llc Apparatus and method for forming self-retaining sutures
EP2249712B8 (en) 2008-02-21 2018-12-26 Ethicon LLC Method and apparatus for elevating retainers on self-retaining sutures
US8216273B1 (en) 2008-02-25 2012-07-10 Ethicon, Inc. Self-retainers with supporting structures on a suture
US8641732B1 (en) 2008-02-26 2014-02-04 Ethicon, Inc. Self-retaining suture with variable dimension filament and method
WO2009117737A2 (en) * 2008-03-21 2009-09-24 Biomimedica, Inc Methods, devices and compositions for adhering hydrated polymer implants to bone
US8128983B2 (en) * 2008-04-11 2012-03-06 Abbott Cardiovascular Systems Inc. Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network
CN102056552B (en) 2008-04-15 2013-07-03 伊西康有限责任公司 Self-retaining sutures with bi-directional retainers or uni-directional retainers
EP2297217B1 (en) * 2008-07-07 2021-10-20 Hyalex Orthopaedics, Inc. Hydrophilic interpenetrating polymer networks derived from hydrophobic polymers
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
US20100170521A1 (en) * 2008-07-24 2010-07-08 Medshape Solutions, Inc. Method and apparatus for deploying a shape memory polymer
US8069858B2 (en) * 2008-07-24 2011-12-06 Medshape Solutions, Inc. Method and apparatus for deploying a shape memory polymer
US8430933B2 (en) * 2008-07-24 2013-04-30 MedShape Inc. Method and apparatus for deploying a shape memory polymer
AU2009279716A1 (en) 2008-08-05 2010-02-11 Biomimedica, Inc Polyurethane-grafted hydrogels
DE102008055870A1 (en) * 2008-10-31 2010-05-06 Gkss-Forschungszentrum Geesthacht Gmbh Multiphase polymer network with triple-shape properties and shape memory effect
MX339174B (en) 2008-11-03 2016-05-12 Ethicon Llc Length of self-retaining suture and method and device for using the same.
WO2011090628A2 (en) 2009-12-29 2011-07-28 Angiotech Pharmaceuticals, Inc. Bidirectional self-retaining sutures with laser-marked and/or non-laser marked indicia and methods
CA2798373C (en) 2010-05-04 2018-10-23 Ethicon, Llc Self-retaining systems having laser-cut retainers
EP3155978B1 (en) 2010-06-11 2022-04-13 Cilag GmbH International Suture delivery tools for endoscopic and robot-assisted surgery
EP2609154B1 (en) 2010-08-27 2020-04-22 Hyalex Orthopaedics, Inc. Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same
WO2012061658A2 (en) 2010-11-03 2012-05-10 Angiotech Pharmaceuticals, Inc. Drug-eluting self-retaining sutures and methods relating thereto
US9675341B2 (en) 2010-11-09 2017-06-13 Ethicon Inc. Emergency self-retaining sutures and packaging
US9427493B2 (en) 2011-03-07 2016-08-30 The Regents Of The University Of Colorado Shape memory polymer intraocular lenses
JP6125488B2 (en) 2011-03-23 2017-05-10 エシコン・エルエルシーEthicon LLC Self-holding variable loop suture
US20130172931A1 (en) 2011-06-06 2013-07-04 Jeffrey M. Gross Methods and devices for soft palate tissue elevation procedures
AU2012319183A1 (en) 2011-10-03 2014-05-22 Biomimedica, Inc. Polymeric adhesive for anchoring compliant materials to another surface
EP2782524B1 (en) 2011-11-21 2017-12-20 Biomimedica, Inc Systems for anchoring orthopaedic implants to bone
US9465127B2 (en) * 2013-05-07 2016-10-11 Pgs Geophysical As Disposable antifouling covers for geophysical survey equipment
KR20170135923A (en) * 2015-04-08 2017-12-08 닛토덴코 가부시키가이샤 Adhesive tape for preventing adhesion of aquatic organisms
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
CN112225873B (en) * 2020-09-15 2022-04-22 万华化学集团股份有限公司 High-transparency fast-forming degradable thermoplastic polyurethane elastomer and preparation method thereof
CN112245664B (en) * 2020-10-16 2021-09-17 浙江大学 Shape memory polymer material for esophagus stent and preparation and application methods
CN113817310B (en) * 2021-07-26 2023-03-24 广州大学 Shape memory composite material and preparation method and application thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7003277A (en) * 1970-03-07 1971-09-09
US4035548A (en) * 1974-05-30 1977-07-12 Ppg Industries, Inc. Laminated articles prepared from transparent, non-blooming poly(lactone-urethane) interlayers
US4085092A (en) * 1974-05-30 1978-04-18 Ppg Industries, Inc. Transparent, optically clear poly(lactone-urethane) interlayers for laminated safety glass
US4857579A (en) * 1980-11-24 1989-08-15 Union Carbide Corporation Thermosettable fiber reinforced resin compositions
ATE124072T1 (en) 1985-01-04 1995-07-15 Thoratec Lab Corp METHOD FOR PRODUCING A MOLDED PART WITH SHAPE MEMORY PROPERTIES AND SOME OF THESE MOLDED PARTS OBTAINED.
US4923934A (en) * 1987-05-29 1990-05-08 Werner Todd A Interpenetrating polymer network of blocked urethane prepolymer, polyol, epoxy resin and anhydride
JPH02118178A (en) 1988-10-28 1990-05-02 Mitsubishi Heavy Ind Ltd Fibrous sheet with shape memory and provision of fibrous sheet product with shape memory nature
JPH02121907A (en) * 1988-10-31 1990-05-09 Mitsubishi Heavy Ind Ltd Cosmetic for human
JPH0747642B2 (en) 1990-06-18 1995-05-24 旭化成工業株式会社 Shape memory resin emulsion and manufacturing method thereof
US5442037A (en) * 1994-09-07 1995-08-15 Tong Yang Nylon Co., Ltd. Polyester prepolymer showing shape-memory effect
DE69426882T2 (en) 1994-10-06 2001-10-04 Tongyang Nylon Co Polyester prepolymer with shape memory effect
PL342996A1 (en) * 1998-02-23 2001-07-16 Mnemoscience Gmbh Shape memory polymers
HU222543B1 (en) * 1998-02-23 2003-08-28 Massachusetts Institute Of Technology Biodegradable shape memory polymers
ID26886A (en) * 1998-03-11 2001-02-15 Dow Chemical Co ARRANGING MATERIALS AND ARTIFICIAL MATERIALS WHICH HAVE MEMORI FORMS MADE FROM α-OLEFIN / VINYL INTERIN OR VOLUTIONS AND AROMATIC VINILIDENTS AND / OR VINILS OR ALIFATIC VINILIDENTS AVOIDED
CA2410637C (en) * 2000-05-31 2007-04-10 Mnemoscience Gmbh Shape memory polymers seeded with dissociated cells for tissue engineering
US6479222B1 (en) * 2000-07-21 2002-11-12 Eastman Kodak Company Protective overcoat for photographic elements
JP2005529095A (en) 2002-04-10 2005-09-29 ネモサイエンス、ゲーエムベーハー Method for achieving a shape memory effect in hair
DE10215858A1 (en) 2002-04-10 2004-03-18 Mnemoscience Gmbh Process for hair treatment with shape memory polymers
DE10217350C1 (en) * 2002-04-18 2003-12-18 Mnemoscience Gmbh polyesterurethanes

Also Published As

Publication number Publication date
EP1362879A2 (en) 2003-11-19
EP1362879B1 (en) 2008-04-02
ATE391145T1 (en) 2008-04-15
ES2303877T3 (en) 2008-09-01
DE50309517D1 (en) 2008-05-15
US7037984B2 (en) 2006-05-02
US20040024143A1 (en) 2004-02-05
CA2425816C (en) 2007-11-20
EP1362879A3 (en) 2004-01-07
DE10217351B3 (en) 2004-02-12

Similar Documents

Publication Publication Date Title
CA2425816A1 (en) Interpenetrating networks
EP2289569A3 (en) Collagen device and method of preparing the same
WO1999011298A3 (en) Reverse phase connective tissue repair composition
AU2003280598A1 (en) Biodegradable substrate, prosthetic material for tissue regeneration and cultured tissue
EP2327724A3 (en) Modified human growth hormone polypeptides and their uses
WO2005034875A3 (en) Method and material for enhance tissue-biomaterial integration
EP1870092A3 (en) Ocular implant
WO2006104976A3 (en) Controlled drug release coating for medical devices
WO2006076416A3 (en) Three dimensional cell protector/pore architecture formation for bone and tissue constructs
EP1852437A3 (en) 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
AU2001267796A1 (en) Polymeric stents and other surgical articles
WO2006118461A3 (en) Modular bioresorbable or biomedical, biologically active supramolecular materials
EP1734971B8 (en) Polymer-based sustained release device
WO2004067044A8 (en) Light-activated adhesive composite, system, and methods
EP2191794A3 (en) Medical devices
AU2003231022A1 (en) Improved membrane for use in sutured or sutureless surgical procedures
AU3818000A (en) Bioactive, bioabsorbable surgical copolymer composites and devices
WO2007056134A3 (en) Resorbable phenolic polymers
EP2093245A3 (en) Biocompatible polymer device
WO2006121887A3 (en) Implantable materials and methods for inhibiting tissue adhesion formation
WO2006049907A3 (en) Implantable devices comprising biologically absorbable star polymers
HK1090936A1 (en) Amphiphilic block copolymer and polymeric composition comprising the same for drug delivery
EP1785108A3 (en) Deployment system for an intraluminal medical device
AU2001280618A1 (en) Biocompatible, expansile material and stent
AU2003251787A1 (en) Polymerized and modified rapamycins and their use in coating medical prostheses

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150417