CA2399406C - Lens implant - Google Patents
Lens implant Download PDFInfo
- Publication number
- CA2399406C CA2399406C CA002399406A CA2399406A CA2399406C CA 2399406 C CA2399406 C CA 2399406C CA 002399406 A CA002399406 A CA 002399406A CA 2399406 A CA2399406 A CA 2399406A CA 2399406 C CA2399406 C CA 2399406C
- Authority
- CA
- Canada
- Prior art keywords
- lens
- lens implant
- implant
- distal surface
- proximal surface
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
- A61F2/1627—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing index of refraction, e.g. by external means or by tilting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
- A61F2/16—Intraocular lenses
- A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
- A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
- A61F2/1635—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing shape
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/008—Phase change materials [PCM], e.g. for storing latent heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0085—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof hardenable in situ, e.g. epoxy resins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0018—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in elasticity, stiffness or compressibility
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0014—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
- A61F2250/0053—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in optical properties
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S623/00—Prosthesis, i.e. artificial body members, parts thereof, or aids and accessories therefor
- Y10S623/902—Method of implanting
- Y10S623/905—Eye
- Y10S623/907—Method of manipulating parts of intraocular lens structure for implantation
Abstract
The lens implant serves to replace the lens body of an eye and possesses substantially the same size and shape. It is elastic such that the eye gets back its capability for accommodation. It consists of two parts (10, 11) with differing refractive indices and/or differing shapes, which allows to adapt the focal length and shape to specific requirements in simple manner. A distal part (11) is prefabricated as pre-made lens part, while the proximal part (10) can preferably be brought into the lens capsule in a flowable state.
Description
BACKGROUND OF THE INVENTION
The invention relates to a lens implant and a kit and a method for producing a lens implant.
A lens implant of this kind is known e.g. from U.S. Pat. No. 4,608,050 or WO
89/00029.
It consists of a flexible body which replaces the lens body of the eye. Its shape and size correspond substantially to the one of the typical lens body. Due to its flexibility it allows an good accommodation of the eye.
In order to adjust this lens implant to the individual requirements of an eye, a plurality of implant bodies with various different refractive indices must be may available. This necessitates large expenditures. It has been found, furthermore, that the implant bodies meet the requirements regarding stability and simultaneous accommodation properties in a limited manner only.
FR 2.698.264 describes a lens consisting of two partial lenses between which a filler mass is arranged. The part lenses form the outer shape of the lens and replace the lens capsule. Because to this connecting the lens to the ocular accommodation mechanism becomes difficult. Furthermore, the mechanical properties of the lens are quite different from the ones of a natural lens which renders the accommodation more difficult.
In U.S. Pat. No. 5,275,623 a lens implant is disclosed which consists of a bag with two lenses. The bag is filled by a gas or a liquid. Due its symmetry, however, this lens features properties that basically deviate from the ones of a natural lens so that it hardly can be satisfactory in practice.
BRIEF SUMMARY OF THE INVENTION
Thus, there is the object to provide a lens implant and a kit and a method, respectively of the kind mentioned above which avoid these drawbacks.
The invention relates to a lens implant and a kit and a method for producing a lens implant.
A lens implant of this kind is known e.g. from U.S. Pat. No. 4,608,050 or WO
89/00029.
It consists of a flexible body which replaces the lens body of the eye. Its shape and size correspond substantially to the one of the typical lens body. Due to its flexibility it allows an good accommodation of the eye.
In order to adjust this lens implant to the individual requirements of an eye, a plurality of implant bodies with various different refractive indices must be may available. This necessitates large expenditures. It has been found, furthermore, that the implant bodies meet the requirements regarding stability and simultaneous accommodation properties in a limited manner only.
FR 2.698.264 describes a lens consisting of two partial lenses between which a filler mass is arranged. The part lenses form the outer shape of the lens and replace the lens capsule. Because to this connecting the lens to the ocular accommodation mechanism becomes difficult. Furthermore, the mechanical properties of the lens are quite different from the ones of a natural lens which renders the accommodation more difficult.
In U.S. Pat. No. 5,275,623 a lens implant is disclosed which consists of a bag with two lenses. The bag is filled by a gas or a liquid. Due its symmetry, however, this lens features properties that basically deviate from the ones of a natural lens so that it hardly can be satisfactory in practice.
BRIEF SUMMARY OF THE INVENTION
Thus, there is the object to provide a lens implant and a kit and a method, respectively of the kind mentioned above which avoid these drawbacks.
This object is met by the lens and the kit and the method, described herein.
The lens implant according to the invention consists thus of a first deformable part and a second part, wherein the two parts have different refractive index and/or different elastic deformability. The first part forms the proximal portion and the second part a distal portion of the lens implant.
Thus the present invention provides a lens implant for placement into the lens capsule and for replacing the lens body of an eye, the lens implant being shaped like a natural lens body, with a distal surface and a proximal surface, wherein the distal surface has a stronger curvature than the proximal surface, the lens implant comprising:
a first portion comprising a flowable material which can be cured intra-ocularly to an elastically deformable state;
and a second portion comprising a solid material having a refractive index or an elastic deformability that differs from the one of the first portion wherein the second portion forms the distal surface, and wherein the first portion forms the proximal surface, wherein a diameter of the first portion perpendicular to a focal axis of the lens exceeds a diameter of the second portion.
The present invention also provides a lens implant for placement into the lens capsule and for replacing the lens body of an eye, the lens implant being shaped like a natural lens body, with a distal surface and a proximal surface, wherein the distal surface has a stronger curvature than the proximal surface, the lens implant comprising:
a first deformable part, which can be cured from a flowable to an elastically deformable state;
and a second part having a refractive index or an elastic deformability that differs from the one of the first part, wherein the second part comprises a bag filled by a filling material and forms the distal surface, and wherein the first part forms the proximal surface, wherein a diameter of the first part perpendicular to a focal axis of the lens exceeds a diameter of the second part.
2a The present invention further provides a lens implant for placement into the lens capsule and for replacing the lens body of an eye, the lens implant configured to replace a natural lens body, with a distal surface and a proximal surface, wherein the distal surface has a stronger curvature than the proximal surface, the lens implant having a convex proximal surface with a radius of curvature between 8.4 and 13.8 mm, a convex distal surface with a radius of curvature between 4.6 and 7.5 mm, and a thickness between 2.8 and 5.5 mm, said lens implant comprising:
a first deformable part, which can be cured from a flowable to an elastically deformable state;
and a second part comprising a bag filled by a filling material and having a refractive index or an elastic deformability that differs from the one of the first part, wherein the second part forms the distal surface, and wherein the first part forms the proximal surface;
wherein the first part is cureable intraocularly from a flowable to an elastically deformable state.
Accordingly, the implant can be set together of two differing parts which allows to adjust the focal distance and/or the mechanical properties to suit the respective requirements in a simple way. Thus, the first part can e.g. basically define the size and the volume, respectively, of the lens and ensure the accommodation while by choosing the second part the focal distance and/or the distal shape can be set.
"'he implant has essentia-iiy t.he shape of the ~ et;s bC.7(A'y- (.<r jJr-..' rej?l,2xcl'J so that 11_. i~.f'.s 1nT:U tl"ie C'YaZiSulE anC1 tlll-s :.'ZP.Ie properly. To this Cncl th~.? c1lstal ;>ur far"-c of= thc?
1:f',P:-c7n;= s^oulil t:ave a strOI?C3,Yr curvature than ..'L~ jjro}~1;Ildl suz'facG~ .
The first part. consists preferably of a mater:.al which is cureablo intraoccularly from a flowable to zn elas-tically defornlable stat.e so that it can be made to adapt to t?-it- shape of the lens body replaced in a simple way.
For a gooa accorruRodating capability the first prir , shUuld be better elastically deformable than the second part, specifical,ly if latter defines thc> distal surface of the lens implant.
The second part can be designed eJ.asti.cally de-forFnab)_P, suitable for a introduction into the lens capsulC2 in a rolled ap or folded state. This is specifically aciva.nta geous in coi:nbination with a cureable first part, because the first part c'an be used in this case for a filling the lens capsule axid guarantees acconunodation capability, t,,rhile the focal dz.stance of the lens implant is given by the second j.Ja.'~ t .
Preferably, the second part forms the discal por-tion of the lens ifnplant so that it forms a wall which sepa-rates the first part frozn the distal part of the lens cap-2, sule. '1'his allows to remove, if ne--cessary, the distal part oi:
the lens capsule if such should become opaque.
The kit for the produGtion of sucl-i lenses in--cludes prefcrably at least one flowable filling material and a plural it-y of pre-shaped lens parts for the rc~rn!iric3 the 30 ond part.
The lens parts feature various different c7-.<pe-, ancllor refractive indices. 1'hus, it is possible t:o produce w.it-h orlly one single fillinq material. a pluralit:-7r o'L lens i.in-plarlt;s of various diftering focal dist:anc<>s anc3 shapes.
- ~ -SHOE'I' DESLRiPTIc 1 OF fiFaR DR?TWTI1vC;S
Further embUC:iments, advantages and applicat.ioris o` the irxvention follo~JS from the dependent cl-aiiris ancJ t.he now #;.o1.:lr,wing descripC_i on with l.-eferctnce to t.r;e drawings. Zt is sho%,az in:
Figure 1 a section through a xiormal eye, Figure 2 a section through an eye with lens im--plant, Figure 3 a possible productiori method for the lens,implant: and Figure 4 a section through an eye with an alter-native enmbodi.men.t of the leris implant.
:JAYS FOR EMk3ODYING THE IN'VEN'1 LON
v The part of the eye that are the most important ones in the present context are illustrated in Fig. 1 and in--clude the lens 1, corisisting of a lens capsule 2 and a lens body 3, the iris and the cornea 5.
The lens 1 is an elastic body of which the curva-ture changer: upon a contraction of Muller'ti muscle 6, so that an accommodatiUn of the eye to various focal clistances be--cornes possible. wi th increasing age, however, the lens body 3 becomEs harcic:r, whic:h l.eads to a partial ur compleLe loss of t:ie accrorr¾nodation property.
The preserit inventioix relates to a lens ii*iplauL.
wh.ich replaces the lens body 3 of t-h.e eye. Such a leris is i.1--I.ustratcd in Fig. 2. It, consists of two transparerit parts :1.0, 1 1 w.(ll i.r'i c7hll :- c3C{cZ1r1st Cc.3cn other crI1Cd J}ll-L17 t:OC E?1 h~
I };r~ e saTtE; size and shap-je "c3:=5 l_he 1=eplclce:C1 1011S 'IJo~_,`z c;c --C'- 1<<r[.QGciL=C: t:,) nj lY lt1'_ f]U:-. L.rF dlstul Sl_li'f C:` lIc: of the t r?illfi',j`> cint is curved st?' oI1gGic than the 5'.Arta c i-=
as is ttlc, case at the lens body- The tcrm p-roximal denotes, iri this rc}crtext, thc iens side facing the cornea, t't"le tc:rtri di.stal the lens side facing th.e retina.
Thc len5 implant has the came :-ize and shape a:: a natuial 1 ens body w2-ten it has a convex prccximal s>urface wi trl 7-0 a:radius of curvature betweLn 8.4 and 13.8 rru-n, a convex dis-tal surface with a radius of curvature bet-,7een 4.6 and 7.5 mrn anc3 a thickness bet reen 2.8 and 5.5 mm. The typical eczuator amounts f.or eyes of grownups to about 9 to 11 cnin _ Typica.l proximal and distal radii of curvature are 10 and 6 mm, re--spectively.
lhe lens implant, i.e_ specificall~:, i-ts fi?'st part, features optical and elastic properties w"rli-ch ar.e simi--3ar Lo t_hose of a lens body with a good accommodation capa-bili*y. zt is usually encloNed tightly by tne lens capsu.le 2 and gener.ai:es, just as a nar.uraJ. lens body, a intracapsulate pressure. Upon contraction of the Miiller'a muscle 6 t-.he cur-vature of the surfaces of the lens implant:, and accordingly its focal width, chariges. Thiis, t_he lens implarlt gives a nati-zral accommociation capability to the eye. To l.lzis end the 211, volume of the fizst part 10 should be larger r_ha_n the one -) f the second part. Preferably also the tot"-a-1 diameter perperl-d:i-(7ula.r to the axis should be 1.arger a',: tfle firsi.: part: than at the second part.
ThF-- tf~,,jr) x-)art:; 10, 11 of the 1.c',Z:~ iiTiplarlt preter'a-b1Yr feat;-aze refractive indi<.es that diifer r17~1T; Pach ::,t.rer.
During tk-iE l,;roduct.l_on of the lens t_he fiz z;t, T1ro_tiimal part- 10 is rrade tcD suit the size and shape o1 the lenti. kaociv 3 Co 1~
repldc_eci whereas the second, distal part :31 is a pre-larnri.cat_eci, elasLi c, shaped body.
Tnlhen producing the lens the two parts 10, 1-- ful-f i l dif f Nrent ot. j ec t s. ThF proximal pcirt 1.0 de f i.nes the vc:~:! -i-imcr~ of the 1.enc- The distal pait 11 rendex-s stabilit.y to the rear lens portiori and allows t.o adjust the focal distance tc-}
the respective eye individually. To this ond a kit is a~rail-able for the person skilled in the art for producing the lens which includes the flowable filling materi.al. and a plt.:rali.ty of pre-fabricated lens parts. The lens parts differ fr-om each other in their refractive index and/or their shape-The lens implant is produced tly bringing together Lhe f:Lowable filling material and one of the lens part-s and the f:il7.ing matexial is cured to the desired r-igidity. This 1_5 can proceed outside of the eye or intraoccularly. He.reto, the eye is initially measured in order to deter-mine the focal distance and the shape of the lens body and, respect-a.vely, in order to detPrmine from the properties of tkze eyc the dEsired refractive index of the implant. From this it can be calcu-lated which of tl;e availablc, J.ens parts 11 shall bc used so that the lerls implant imitates the desired focal distance close as possible.
Tn a preferred production method the lens implant, is produced in.traoccularly. Hereto, in the first step a small opening is cut into the lens capsule 2 and the lens body 3 is x-emovc-.ci. This proceeds preferably by ultrasonics, laser tec7h-nique, phacoerttulsificatiori or laserfakoerrralsif_ication. Cori.-e-spond:ing methods ar> known to the person ski 1- i_r~d in the art.
The distal part 11 of the len:~ is introdu<<eci -~0 theroafter into Lhe lens capsule which has been hcAlowed ac-curdingl y. :tiz orcler to allow the lens par t 11. to be i nserted even through such a small opening, it is elasLically dezorm--al,l so that they can be rolled up or folded and be inserted by ineans of a in-jection ia.strti.xTrent-- s'crumeiit of t 1-;i<;
i : . dI s,clo;c.d e . g . iri US 4Sn '1'he distal part which has been inscrtc:d ey_;Pnds atzcl rougli.L-;r att.a.ins l_ ~P desired position i.n the lens capsu_e.
In a rcla2.red sl_ate it has a concave-concave curvat~i.r_e cii_e-h as is d'i Uc].osed in Fi.qs. 2 and 3. It forrns the c.i.istal sida ot thP_ lerls implant ar?d tt7e shape ot its convex surface 12cl coi--resporids to the one of the distal surface of the lens bodv to be replaced. Depending on what is :t:equired froin the optical.
and mechanical properties, the distal part: 11 can also b,e bi-convex, i.e. its pxoxi.mal surface can be bent towards the front or towards the 'a~~cl=c or be planar.
After the distal lens part has been positioned, ~
the proximal lens part 10 is injected irzt(:) the lens capsule i5 through a injection apparatus 13 in the form of a filling mri-terial in a flowable state and the lens capsule 2 is filled iri its state accommodated to infinity. In this step, such az-i amount of filling material is injected that the volume of the lerrs implant corresponds substantially to the oxie of the pre--viously removed leris body.
The lens capsule is, thereafter, closed and the proxiraal lens part. 10 is cured to the desircd rigidity, which can be achieved e.g. by a chemically, c;lectrically or opti-cally induced cross-linking. Suitable filling materials and 25: techn:iqques are known to t,he person skil lec`i in the art. C.<x.
from IJS 4 . Oi18_ (;ti0 or [fd0 89/00029.
A cross-lirikec: polysiloxar:e, ci hydrogel or- a co1.--layer.--preparatiori ca?z- e.g. be used as a fillirig mateiicrl.
Preferably, a gel. is uscd because regardax.u it. t-ias a consis-3~~ t:r_nc~_r sirnilar to the leiis body.
Arianging of the px.e-fabricate.d. lens part 11 ar tr.he distal side of the lens has the advantage that it forms a relativelv stable rear wall for the lens. Iw a clouding oc-cur; ri ft.er e impJ-antinc; at the dis tal area of t:i,e icr::= c ir sule 2 , thc 1-ens r-ansule 2 cari k?e removed it1 s,-c}-i tlz_s b"r mc-ans of laser r_tys . =he l ens part il elds also witt'ic,t_ii_ lF=iz~ c~-ipsule 2 t.]ne possibly still flovr~ble, physiologi cally le:>.1 co:r.patible first lens part 10 f'r~-om the vitrzous body o1 tl eye. .3r,d all otre- struc.tures of the i nterior of t'rte, eye.
Lie.cat.^P opening of the rear capsule by a 1ase~r is never uili form, the soft'Gr matc~rial of the first lens part would othex--wise leak out at the back because the capsule is Subje-cted to pressure - This would destroy the optical function of the lens.]_,ens part 11 prevents such a leakagi= .
However, in particular if a moze stable, pnvsio--1.ogicallY/ well cornpat.ible material is used for the fi rst lcns part 10, the second lens part 1.1 can e.g. also be located in tlie center or .in a proximal portion of the lens implant .
a second embodiment of the in'~.,ention is illus-trG.`ed in Fig. 4. Hcre the dist-al part corlsists of a hag 11a which is filled by the transparent filling matera.al lib. This structure has the advantage of producing a relatively large 2() distal part 11a, 11b without that a large hole must be made in the lens capsule. After removing the .].erls body 3, the bag 11a is fi-.r,st inserted in an empty, rolled st-at.e into the lens capsule- Thereafter a injecti(Dn needle is inserted through the same opening. By means of the needle -he filling materi.=3l 111-) is fc_d i nto the baq 11a . Finally, the proximal part 10 is f i 11 e c1 in.
The bag lla is cuL' and pre-shaped in such a nrLzn ric~ r that it attains the desired shape in the filled state. IrI
trl,_ kit mer!tioned abov(-:~ at least a part of the pre-shaped J_ens ;Da:rts, irI particular the lurger ones thrrec-)f, tnay be i_,r>vi_cie l as bags 11a.
5ubje.c_t of the prEserit inventiori is a leiis in-L-plant alicl c~ kit ftDy trie procluctlon of suCk- lens iYC:plant :: Thc -- ~i in-=re.ntion rF!.ateN, hocvever, alsc~ to thc< above c1e5cr.ibecl, ir.--tT:loccular ITlet_hOo of production, in which 'hP- fil.i1nG 111ate -rial for thc L'irst part -1_0 (Df the lens is i--itrodtaced in a Llc_,wat-)le SLa.I-.e aiid a suitable lens part il is izltrod_iced i.n a solid st-aLe into the lens capsule -2. Preterably, the rigidity of the first lens part is thereafter increased by a cu.ra.n.g.
Durinq tciis, the capsule should be e-ccortunociated to infinity.
Whereas i-n the preseni- applicatioi-, preterred c:m-bod:iments of the invention are described, it shall be ~U clr-early understood that the invention is not limited thereto but can he also embodied otherwise within the scope of the following claims.
The lens implant according to the invention consists thus of a first deformable part and a second part, wherein the two parts have different refractive index and/or different elastic deformability. The first part forms the proximal portion and the second part a distal portion of the lens implant.
Thus the present invention provides a lens implant for placement into the lens capsule and for replacing the lens body of an eye, the lens implant being shaped like a natural lens body, with a distal surface and a proximal surface, wherein the distal surface has a stronger curvature than the proximal surface, the lens implant comprising:
a first portion comprising a flowable material which can be cured intra-ocularly to an elastically deformable state;
and a second portion comprising a solid material having a refractive index or an elastic deformability that differs from the one of the first portion wherein the second portion forms the distal surface, and wherein the first portion forms the proximal surface, wherein a diameter of the first portion perpendicular to a focal axis of the lens exceeds a diameter of the second portion.
The present invention also provides a lens implant for placement into the lens capsule and for replacing the lens body of an eye, the lens implant being shaped like a natural lens body, with a distal surface and a proximal surface, wherein the distal surface has a stronger curvature than the proximal surface, the lens implant comprising:
a first deformable part, which can be cured from a flowable to an elastically deformable state;
and a second part having a refractive index or an elastic deformability that differs from the one of the first part, wherein the second part comprises a bag filled by a filling material and forms the distal surface, and wherein the first part forms the proximal surface, wherein a diameter of the first part perpendicular to a focal axis of the lens exceeds a diameter of the second part.
2a The present invention further provides a lens implant for placement into the lens capsule and for replacing the lens body of an eye, the lens implant configured to replace a natural lens body, with a distal surface and a proximal surface, wherein the distal surface has a stronger curvature than the proximal surface, the lens implant having a convex proximal surface with a radius of curvature between 8.4 and 13.8 mm, a convex distal surface with a radius of curvature between 4.6 and 7.5 mm, and a thickness between 2.8 and 5.5 mm, said lens implant comprising:
a first deformable part, which can be cured from a flowable to an elastically deformable state;
and a second part comprising a bag filled by a filling material and having a refractive index or an elastic deformability that differs from the one of the first part, wherein the second part forms the distal surface, and wherein the first part forms the proximal surface;
wherein the first part is cureable intraocularly from a flowable to an elastically deformable state.
Accordingly, the implant can be set together of two differing parts which allows to adjust the focal distance and/or the mechanical properties to suit the respective requirements in a simple way. Thus, the first part can e.g. basically define the size and the volume, respectively, of the lens and ensure the accommodation while by choosing the second part the focal distance and/or the distal shape can be set.
"'he implant has essentia-iiy t.he shape of the ~ et;s bC.7(A'y- (.<r jJr-..' rej?l,2xcl'J so that 11_. i~.f'.s 1nT:U tl"ie C'YaZiSulE anC1 tlll-s :.'ZP.Ie properly. To this Cncl th~.? c1lstal ;>ur far"-c of= thc?
1:f',P:-c7n;= s^oulil t:ave a strOI?C3,Yr curvature than ..'L~ jjro}~1;Ildl suz'facG~ .
The first part. consists preferably of a mater:.al which is cureablo intraoccularly from a flowable to zn elas-tically defornlable stat.e so that it can be made to adapt to t?-it- shape of the lens body replaced in a simple way.
For a gooa accorruRodating capability the first prir , shUuld be better elastically deformable than the second part, specifical,ly if latter defines thc> distal surface of the lens implant.
The second part can be designed eJ.asti.cally de-forFnab)_P, suitable for a introduction into the lens capsulC2 in a rolled ap or folded state. This is specifically aciva.nta geous in coi:nbination with a cureable first part, because the first part c'an be used in this case for a filling the lens capsule axid guarantees acconunodation capability, t,,rhile the focal dz.stance of the lens implant is given by the second j.Ja.'~ t .
Preferably, the second part forms the discal por-tion of the lens ifnplant so that it forms a wall which sepa-rates the first part frozn the distal part of the lens cap-2, sule. '1'his allows to remove, if ne--cessary, the distal part oi:
the lens capsule if such should become opaque.
The kit for the produGtion of sucl-i lenses in--cludes prefcrably at least one flowable filling material and a plural it-y of pre-shaped lens parts for the rc~rn!iric3 the 30 ond part.
The lens parts feature various different c7-.<pe-, ancllor refractive indices. 1'hus, it is possible t:o produce w.it-h orlly one single fillinq material. a pluralit:-7r o'L lens i.in-plarlt;s of various diftering focal dist:anc<>s anc3 shapes.
- ~ -SHOE'I' DESLRiPTIc 1 OF fiFaR DR?TWTI1vC;S
Further embUC:iments, advantages and applicat.ioris o` the irxvention follo~JS from the dependent cl-aiiris ancJ t.he now #;.o1.:lr,wing descripC_i on with l.-eferctnce to t.r;e drawings. Zt is sho%,az in:
Figure 1 a section through a xiormal eye, Figure 2 a section through an eye with lens im--plant, Figure 3 a possible productiori method for the lens,implant: and Figure 4 a section through an eye with an alter-native enmbodi.men.t of the leris implant.
:JAYS FOR EMk3ODYING THE IN'VEN'1 LON
v The part of the eye that are the most important ones in the present context are illustrated in Fig. 1 and in--clude the lens 1, corisisting of a lens capsule 2 and a lens body 3, the iris and the cornea 5.
The lens 1 is an elastic body of which the curva-ture changer: upon a contraction of Muller'ti muscle 6, so that an accommodatiUn of the eye to various focal clistances be--cornes possible. wi th increasing age, however, the lens body 3 becomEs harcic:r, whic:h l.eads to a partial ur compleLe loss of t:ie accrorr¾nodation property.
The preserit inventioix relates to a lens ii*iplauL.
wh.ich replaces the lens body 3 of t-h.e eye. Such a leris is i.1--I.ustratcd in Fig. 2. It, consists of two transparerit parts :1.0, 1 1 w.(ll i.r'i c7hll :- c3C{cZ1r1st Cc.3cn other crI1Cd J}ll-L17 t:OC E?1 h~
I };r~ e saTtE; size and shap-je "c3:=5 l_he 1=eplclce:C1 1011S 'IJo~_,`z c;c --C'- 1<<r[.QGciL=C: t:,) nj lY lt1'_ f]U:-. L.rF dlstul Sl_li'f C:` lIc: of the t r?illfi',j`> cint is curved st?' oI1gGic than the 5'.Arta c i-=
as is ttlc, case at the lens body- The tcrm p-roximal denotes, iri this rc}crtext, thc iens side facing the cornea, t't"le tc:rtri di.stal the lens side facing th.e retina.
Thc len5 implant has the came :-ize and shape a:: a natuial 1 ens body w2-ten it has a convex prccximal s>urface wi trl 7-0 a:radius of curvature betweLn 8.4 and 13.8 rru-n, a convex dis-tal surface with a radius of curvature bet-,7een 4.6 and 7.5 mrn anc3 a thickness bet reen 2.8 and 5.5 mm. The typical eczuator amounts f.or eyes of grownups to about 9 to 11 cnin _ Typica.l proximal and distal radii of curvature are 10 and 6 mm, re--spectively.
lhe lens implant, i.e_ specificall~:, i-ts fi?'st part, features optical and elastic properties w"rli-ch ar.e simi--3ar Lo t_hose of a lens body with a good accommodation capa-bili*y. zt is usually encloNed tightly by tne lens capsu.le 2 and gener.ai:es, just as a nar.uraJ. lens body, a intracapsulate pressure. Upon contraction of the Miiller'a muscle 6 t-.he cur-vature of the surfaces of the lens implant:, and accordingly its focal width, chariges. Thiis, t_he lens implarlt gives a nati-zral accommociation capability to the eye. To l.lzis end the 211, volume of the fizst part 10 should be larger r_ha_n the one -) f the second part. Preferably also the tot"-a-1 diameter perperl-d:i-(7ula.r to the axis should be 1.arger a',: tfle firsi.: part: than at the second part.
ThF-- tf~,,jr) x-)art:; 10, 11 of the 1.c',Z:~ iiTiplarlt preter'a-b1Yr feat;-aze refractive indi<.es that diifer r17~1T; Pach ::,t.rer.
During tk-iE l,;roduct.l_on of the lens t_he fiz z;t, T1ro_tiimal part- 10 is rrade tcD suit the size and shape o1 the lenti. kaociv 3 Co 1~
repldc_eci whereas the second, distal part :31 is a pre-larnri.cat_eci, elasLi c, shaped body.
Tnlhen producing the lens the two parts 10, 1-- ful-f i l dif f Nrent ot. j ec t s. ThF proximal pcirt 1.0 de f i.nes the vc:~:! -i-imcr~ of the 1.enc- The distal pait 11 rendex-s stabilit.y to the rear lens portiori and allows t.o adjust the focal distance tc-}
the respective eye individually. To this ond a kit is a~rail-able for the person skilled in the art for producing the lens which includes the flowable filling materi.al. and a plt.:rali.ty of pre-fabricated lens parts. The lens parts differ fr-om each other in their refractive index and/or their shape-The lens implant is produced tly bringing together Lhe f:Lowable filling material and one of the lens part-s and the f:il7.ing matexial is cured to the desired r-igidity. This 1_5 can proceed outside of the eye or intraoccularly. He.reto, the eye is initially measured in order to deter-mine the focal distance and the shape of the lens body and, respect-a.vely, in order to detPrmine from the properties of tkze eyc the dEsired refractive index of the implant. From this it can be calcu-lated which of tl;e availablc, J.ens parts 11 shall bc used so that the lerls implant imitates the desired focal distance close as possible.
Tn a preferred production method the lens implant, is produced in.traoccularly. Hereto, in the first step a small opening is cut into the lens capsule 2 and the lens body 3 is x-emovc-.ci. This proceeds preferably by ultrasonics, laser tec7h-nique, phacoerttulsificatiori or laserfakoerrralsif_ication. Cori.-e-spond:ing methods ar> known to the person ski 1- i_r~d in the art.
The distal part 11 of the len:~ is introdu<<eci -~0 theroafter into Lhe lens capsule which has been hcAlowed ac-curdingl y. :tiz orcler to allow the lens par t 11. to be i nserted even through such a small opening, it is elasLically dezorm--al,l so that they can be rolled up or folded and be inserted by ineans of a in-jection ia.strti.xTrent-- s'crumeiit of t 1-;i<;
i : . dI s,clo;c.d e . g . iri US 4Sn '1'he distal part which has been inscrtc:d ey_;Pnds atzcl rougli.L-;r att.a.ins l_ ~P desired position i.n the lens capsu_e.
In a rcla2.red sl_ate it has a concave-concave curvat~i.r_e cii_e-h as is d'i Uc].osed in Fi.qs. 2 and 3. It forrns the c.i.istal sida ot thP_ lerls implant ar?d tt7e shape ot its convex surface 12cl coi--resporids to the one of the distal surface of the lens bodv to be replaced. Depending on what is :t:equired froin the optical.
and mechanical properties, the distal part: 11 can also b,e bi-convex, i.e. its pxoxi.mal surface can be bent towards the front or towards the 'a~~cl=c or be planar.
After the distal lens part has been positioned, ~
the proximal lens part 10 is injected irzt(:) the lens capsule i5 through a injection apparatus 13 in the form of a filling mri-terial in a flowable state and the lens capsule 2 is filled iri its state accommodated to infinity. In this step, such az-i amount of filling material is injected that the volume of the lerrs implant corresponds substantially to the oxie of the pre--viously removed leris body.
The lens capsule is, thereafter, closed and the proxiraal lens part. 10 is cured to the desircd rigidity, which can be achieved e.g. by a chemically, c;lectrically or opti-cally induced cross-linking. Suitable filling materials and 25: techn:iqques are known to t,he person skil lec`i in the art. C.<x.
from IJS 4 . Oi18_ (;ti0 or [fd0 89/00029.
A cross-lirikec: polysiloxar:e, ci hydrogel or- a co1.--layer.--preparatiori ca?z- e.g. be used as a fillirig mateiicrl.
Preferably, a gel. is uscd because regardax.u it. t-ias a consis-3~~ t:r_nc~_r sirnilar to the leiis body.
Arianging of the px.e-fabricate.d. lens part 11 ar tr.he distal side of the lens has the advantage that it forms a relativelv stable rear wall for the lens. Iw a clouding oc-cur; ri ft.er e impJ-antinc; at the dis tal area of t:i,e icr::= c ir sule 2 , thc 1-ens r-ansule 2 cari k?e removed it1 s,-c}-i tlz_s b"r mc-ans of laser r_tys . =he l ens part il elds also witt'ic,t_ii_ lF=iz~ c~-ipsule 2 t.]ne possibly still flovr~ble, physiologi cally le:>.1 co:r.patible first lens part 10 f'r~-om the vitrzous body o1 tl eye. .3r,d all otre- struc.tures of the i nterior of t'rte, eye.
Lie.cat.^P opening of the rear capsule by a 1ase~r is never uili form, the soft'Gr matc~rial of the first lens part would othex--wise leak out at the back because the capsule is Subje-cted to pressure - This would destroy the optical function of the lens.]_,ens part 11 prevents such a leakagi= .
However, in particular if a moze stable, pnvsio--1.ogicallY/ well cornpat.ible material is used for the fi rst lcns part 10, the second lens part 1.1 can e.g. also be located in tlie center or .in a proximal portion of the lens implant .
a second embodiment of the in'~.,ention is illus-trG.`ed in Fig. 4. Hcre the dist-al part corlsists of a hag 11a which is filled by the transparent filling matera.al lib. This structure has the advantage of producing a relatively large 2() distal part 11a, 11b without that a large hole must be made in the lens capsule. After removing the .].erls body 3, the bag 11a is fi-.r,st inserted in an empty, rolled st-at.e into the lens capsule- Thereafter a injecti(Dn needle is inserted through the same opening. By means of the needle -he filling materi.=3l 111-) is fc_d i nto the baq 11a . Finally, the proximal part 10 is f i 11 e c1 in.
The bag lla is cuL' and pre-shaped in such a nrLzn ric~ r that it attains the desired shape in the filled state. IrI
trl,_ kit mer!tioned abov(-:~ at least a part of the pre-shaped J_ens ;Da:rts, irI particular the lurger ones thrrec-)f, tnay be i_,r>vi_cie l as bags 11a.
5ubje.c_t of the prEserit inventiori is a leiis in-L-plant alicl c~ kit ftDy trie procluctlon of suCk- lens iYC:plant :: Thc -- ~i in-=re.ntion rF!.ateN, hocvever, alsc~ to thc< above c1e5cr.ibecl, ir.--tT:loccular ITlet_hOo of production, in which 'hP- fil.i1nG 111ate -rial for thc L'irst part -1_0 (Df the lens is i--itrodtaced in a Llc_,wat-)le SLa.I-.e aiid a suitable lens part il is izltrod_iced i.n a solid st-aLe into the lens capsule -2. Preterably, the rigidity of the first lens part is thereafter increased by a cu.ra.n.g.
Durinq tciis, the capsule should be e-ccortunociated to infinity.
Whereas i-n the preseni- applicatioi-, preterred c:m-bod:iments of the invention are described, it shall be ~U clr-early understood that the invention is not limited thereto but can he also embodied otherwise within the scope of the following claims.
Claims (16)
1. A lens implant for placement into the lens capsule and for replacing the lens body of an eye, the lens implant being shaped like a natural lens body, with a distal surface and a proximal surface, wherein the distal surface has a stronger curvature than the proximal surface, the lens implant comprising:
a first portion comprising a flowable material which can be cured intra-ocularly to an elastically deformable state;
and a second portion comprising a solid material having a refractive index or an elastic deformability that differs from the one of the first portion wherein the second portion forms the distal surface, and wherein the first portion forms the proximal surface, wherein a diameter of the first portion perpendicular to a focal axis of the lens exceeds a diameter of the second portion.
a first portion comprising a flowable material which can be cured intra-ocularly to an elastically deformable state;
and a second portion comprising a solid material having a refractive index or an elastic deformability that differs from the one of the first portion wherein the second portion forms the distal surface, and wherein the first portion forms the proximal surface, wherein a diameter of the first portion perpendicular to a focal axis of the lens exceeds a diameter of the second portion.
2. A lens implant for placement into the lens capsule and for replacing the lens body of an eye, the lens implant being shaped like a natural lens body, with a distal surface and a proximal surface, wherein the distal surface has a stronger curvature than the proximal surface, the lens implant comprising:
a first deformable part, which can be cured from a flowable to an elastically deformable state;
and a second part having a refractive index or an elastic deformability that differs from the one of the first part, wherein the second part comprises a bag filled by a filling material and forms the distal surface, and wherein the first part forms the proximal surface, wherein a diameter of the first part perpendicular to a focal axis of the lens exceeds a diameter of the second part.
a first deformable part, which can be cured from a flowable to an elastically deformable state;
and a second part having a refractive index or an elastic deformability that differs from the one of the first part, wherein the second part comprises a bag filled by a filling material and forms the distal surface, and wherein the first part forms the proximal surface, wherein a diameter of the first part perpendicular to a focal axis of the lens exceeds a diameter of the second part.
3. The lens implant of claim 2, wherein the second part has a refractive index which differs from the one of the first part.
4. The lens implant of claim 2, wherein the first part and the second part abut against each other.
5. The lens implant of claim 2, wherein the second part is elastically deformable for introduction into the lens capsule in a rolled up or folded state.
6. The lens implant of claim 2, wherein the lens implant consists of the first part and the second part.
7. The lens implant of claim 2, wherein a distal side of the second part is curved in its relaxed state for forming the convex distal surface of the lens implant.
8. The lens implant of claim 2 wherein the first part includes at least a material selected from the group consisting of cross-linked polysiloxanes, hydrogels and collagen preparations.
9. The lens implant of claim 2, wherein the first part has a higher deformability than the second part.
10. The lens implant of claim 2, wherein the first part is better elastically deformable than the second part.
11. The lens implant of claim 2, wherein the first part is a gel.
12. The lens implant of claim 2, wherein the proximal surface is convex with a radius of curvature between 8.4 and 13.8 mm, and wherein the distal surface is convex with a radius of curvature between 4.6 and 7.5 mm, and wherein the lens implant has a thickness between 2.8 and 5.5 mm.
13. The lens implant of claim 2, wherein it is dimensioned and shaped in such a manner that it has substantially the dimensions and shape of a natural lens body accommodated to infinity.
14. The lens implant of claim 2, wherein the first part has a volume that exceeds the volume of the second part.
15. A lens implant for placement into the lens capsule and for replacing the lens body of an eye, the lens implant configured to replace a natural lens body, with a distal surface and a proximal surface, wherein the distal surface has a stronger curvature than the proximal surface, the lens implant having a convex proximal surface with a radius of curvature between 8.4 and 13.8 mm, a convex distal surface with a radius of curvature between 4.6 and 7.5 mm, and a thickness between 2.8 and 5.5 mm, said lens implant comprising:
a first deformable part, which can be cured from a flowable to an elastically deformable state;
and a second part comprising a bag filled by a filling material and having a refractive index or an elastic deformability that differs from the one of the first part, wherein the second part forms the distal surface, and wherein the first part forms the proximal surface;
wherein the first part is cureable intraocularly from a flowable to an elastically deformable state.
a first deformable part, which can be cured from a flowable to an elastically deformable state;
and a second part comprising a bag filled by a filling material and having a refractive index or an elastic deformability that differs from the one of the first part, wherein the second part forms the distal surface, and wherein the first part forms the proximal surface;
wherein the first part is cureable intraocularly from a flowable to an elastically deformable state.
16. The lens implant of claim 15, wherein the first part has a diameter that exceeds the diameter of the second part.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH2122000 | 2000-02-03 | ||
| CH212/00 | 2000-02-03 | ||
| PCT/IB2001/000091 WO2001056508A1 (en) | 2000-02-03 | 2001-01-26 | Lens implant |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2399406A1 CA2399406A1 (en) | 2003-03-05 |
| CA2399406C true CA2399406C (en) | 2009-01-20 |
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ID=4447691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002399406A Expired - Lifetime CA2399406C (en) | 2000-02-03 | 2001-01-26 | Lens implant |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6960230B2 (en) |
| EP (1) | EP1251801B1 (en) |
| JP (1) | JP4261801B2 (en) |
| AT (1) | ATE442105T1 (en) |
| AU (1) | AU2001225434A1 (en) |
| CA (1) | CA2399406C (en) |
| DE (1) | DE50115099D1 (en) |
| ES (1) | ES2330721T3 (en) |
| WO (1) | WO2001056508A1 (en) |
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2001
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- 2001-01-26 EP EP01900600A patent/EP1251801B1/en not_active Expired - Lifetime
- 2001-01-26 WO PCT/IB2001/000091 patent/WO2001056508A1/en active Application Filing
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- 2001-01-26 DE DE50115099T patent/DE50115099D1/en not_active Expired - Lifetime
- 2001-01-26 CA CA002399406A patent/CA2399406C/en not_active Expired - Lifetime
- 2001-01-26 US US10/182,065 patent/US6960230B2/en not_active Expired - Lifetime
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| EP1251801B1 (en) | 2009-09-09 |
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| US20030004569A1 (en) | 2003-01-02 |
| JP2003521335A (en) | 2003-07-15 |
| ES2330721T3 (en) | 2009-12-15 |
| US6960230B2 (en) | 2005-11-01 |
| CA2399406A1 (en) | 2003-03-05 |
| WO2001056508A1 (en) | 2001-08-09 |
| EP1251801A1 (en) | 2002-10-30 |
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