CA2392006A1 - Microfabricated devices for the delivery of molecules into a carrier fluid - Google Patents

Microfabricated devices for the delivery of molecules into a carrier fluid Download PDF

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Publication number
CA2392006A1
CA2392006A1 CA002392006A CA2392006A CA2392006A1 CA 2392006 A1 CA2392006 A1 CA 2392006A1 CA 002392006 A CA002392006 A CA 002392006A CA 2392006 A CA2392006 A CA 2392006A CA 2392006 A1 CA2392006 A1 CA 2392006A1
Authority
CA
Canada
Prior art keywords
molecules
carrier fluid
reservoirs
release
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002392006A
Other languages
French (fr)
Other versions
CA2392006C (en
Inventor
John T. Santini, Jr.
Charles Hutchinson
Scott Albert Uhland
Michael J. Cima
Robert S. Langer
Dennis Ausiello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Scientific Scimed Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2392006A1 publication Critical patent/CA2392006A1/en
Application granted granted Critical
Publication of CA2392006C publication Critical patent/CA2392006C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0097Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52Adding ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/003Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
    • A61M15/0031Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up by bursting or breaking the package, i.e. without cutting or piercing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0028Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
    • A61M15/0045Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
    • A61M15/0046Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
    • A61M15/005Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged on a cylindrical surface
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/008Electronic counters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/1407Infusion of two or more substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0014Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis
    • A61F2250/0035Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof having different values of a given property or geometrical feature, e.g. mechanical property or material property, at different locations within the same prosthesis differing in release or diffusion time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2250/00Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2250/0058Additional features; Implant or prostheses properties not otherwise provided for
    • A61F2250/0067Means for introducing or releasing pharmaceutical products into the body
    • A61F2250/0068Means for introducing or releasing pharmaceutical products into the body the pharmaceutical product being in a reservoir
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/416Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/0065Inhalators with dosage or measuring devices
    • A61M15/0068Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/0083Timers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00Inhalators
    • A61M15/009Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/82Internal energy supply devices
    • A61M2205/8218Gas operated
    • A61M2205/8225Gas operated using incorporated gas cartridges for the driving gas

Abstract

Apparati and methods are provided for the delivery of molecules to a site via a carrier fluid. The apparati include microchip devices whcih have reservoirs containing the molecules for release.
The apparati and methods provide for active or passive controlled relase of the molecules. Preferred embodiments include systems for intravenous administration of drugs, wherein drug molecules are released from the microchip devices into a carrier fluid ex vivo, such as a saline solution, forming a drug/saline solution mixture which is then delivered to a patient intravenously.

Claims (28)

1. An apparatus for the controlled release of molecules into a carrier fluid comprising:
(i) a microchip device having a plurality of reservoirs containing the molecules for release, and (ii) a mixing chamber which comprises a structure through which a carrier fluid can flow, the mixing chamber being positioned adjacent to or downstream of the microchip device with respect to the flow of the carrier fluid, wherein the molecules are combined with the carrier fluid following release of the molecules from one or more of the reservoirs.
2. The apparatus of claim 1 further comprising a container of a carrier fluid which can be in fluid communication with the mixing chamber and serves as a source of the carrier fluid which flows through the structure.
3. The apparatus of claim 1 further comprising a mixer.
4. The apparatus of claim 1 further comprising a pump.
5. The apparatus of claim 1 or 2 wherein the molecules are drug molecules and the carrier fluid is a physiologically acceptable fluid for intravenous administration.
6. The apparatus of claim 5 wherein the reservoirs of the microchip device are covered by reservoir caps which can be selectively ruptwed or disintegrated to release the molecules into the carrier fluid ex vivo.
7. The apparatus of claim 5 wherein the carrier fluid is selected from the group consisting of water, saline, blood plasma, whole blood, and sugar solutions.
8. The apparatus of claim 2 wherein the container is an IV bag or bottle.
9. The apparatus of claim 1 wherein the molecules in the reservoirs are in a stable dry form prior to contact with the carrier fluid.
10. The apparatus of claim 5 wherein the mixing chamber comprises an outlet from which a mixture of carrier fluid and drug flows, and wherein a length of hollow tubing is connected to the outlet for intravenous connection to a patient.
11. The apparatus of claim 1 comprising two or more microchip devices.
12. The apparatus of claim 5 wherein the mixing chamber is provided in a console adapted to receive one or more replaceable cartridges, each of which contains at least one microchip device.
13. The apparatus of claim 5 further comprising an electronic control system in communication with the microchip device.
14. The apparatus of claim 13 wherein the communication is wireless.
15. The apparatus of claim 5 having a label identifying the drug contained in the microchip device.
16. The apparatus of claim 15 wherein the label comprises information in an electronically readable form.
17. The apparatus of claim 5 wherein the mixing chamber is integrated into a metered dose inhaler.
18. A device for the release of molecules in vivo comprising:
a medical stent, and a microchip device having a plurality of reservoirs containing the molecules for release, wherein the microchip device is integrated into or is attached to a surface of the medical stent.
19. A device for the release of drug molecules in vivo comprising a medical stent having a plurality of microfabricated reservoirs containing the drug molecules for release.
20. The device of claim 18 or 19 wherein the stent is a cardiovascular stent.
21. The device of claim 19 wherein the drug is an anti-restenosis agent.
22. The apparatus of claim 1 or 2 wherein the molecules comprise fragrance molecules.
23. The apparatus of claim 1 or 2 wherein the molecules comprise a beverage additive.
24. A device for the controlled delivery of molecules comprising:
(i) a microchip device having a plurality of reservoirs containing the molecules and sealed by reservoir caps, and (ii) an implantable delivery system comprising a pump, wherein the reservoirs of the microchip device are selectively exposed to the flow of fluid, in vivo, in the delivery system, and wherein the molecules are released from the reservoirs, upon disintegration of the reservoir caps, during fluid flow in the delivery system.
25. A method for the delivery of molecules to a site comprising:
(a) providing the apparatus of claim 1;
(b) selectively exposing the reservoirs of the microchip device to the carrier fluid, thereby causing the molecules to be released from the reservoirs and combine with the carrier fluid to form a molecule/carrier fluid mixture, and (c) transporting the molecule/carrier fluid mixture to the site.
26. The method of claim 25 wherein the site is in a human or animal and wherein the molecules are drug molecules.
27. The method of claim 26 wherein the transporting step is by intravenous administration.
28. The method of claim 27 wherein the carrier fluid is selected from the group consisting of water, saline, blood plasma, whole blood, and sugar solutions.
CA2392006A 1999-11-17 2000-11-17 Microfabricated devices for the delivery of molecules into a carrier fluid Expired - Fee Related CA2392006C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16637099P 1999-11-17 1999-11-17
US60/166,370 1999-11-17
PCT/US2000/031529 WO2001035928A1 (en) 1999-11-17 2000-11-17 Microfabricated devices for the delivery of molecules into a carrier fluid

Publications (2)

Publication Number Publication Date
CA2392006A1 true CA2392006A1 (en) 2001-05-25
CA2392006C CA2392006C (en) 2011-03-15

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2392006A Expired - Fee Related CA2392006C (en) 1999-11-17 2000-11-17 Microfabricated devices for the delivery of molecules into a carrier fluid

Country Status (9)

Country Link
US (7) US6491666B1 (en)
EP (3) EP2308522A3 (en)
JP (4) JP2003513755A (en)
AT (1) ATE425738T1 (en)
AU (1) AU770395B2 (en)
CA (1) CA2392006C (en)
DE (1) DE60041825D1 (en)
ES (1) ES2332869T3 (en)
WO (1) WO2001035928A1 (en)

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US7052488B2 (en) 2006-05-30
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US20060217798A1 (en) 2006-09-28
US20040260391A1 (en) 2004-12-23
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WO2001035928A1 (en) 2001-05-25
JP2006328083A (en) 2006-12-07
US7041130B2 (en) 2006-05-09
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US20030100865A1 (en) 2003-05-29
US20110245914A1 (en) 2011-10-06
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EP1690527A3 (en) 2009-08-05
US20040034332A1 (en) 2004-02-19
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US6537256B2 (en) 2003-03-25
EP1690527A2 (en) 2006-08-16
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EP2308522A3 (en) 2012-02-29
US20020173745A1 (en) 2002-11-21
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AU770395B2 (en) 2004-02-19
US6491666B1 (en) 2002-12-10

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