CA2311704A1 - Tiltable nut - Google Patents

Tiltable nut Download PDF

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Publication number
CA2311704A1
CA2311704A1 CA002311704A CA2311704A CA2311704A1 CA 2311704 A1 CA2311704 A1 CA 2311704A1 CA 002311704 A CA002311704 A CA 002311704A CA 2311704 A CA2311704 A CA 2311704A CA 2311704 A1 CA2311704 A1 CA 2311704A1
Authority
CA
Canada
Prior art keywords
spindle
nut
nut member
piston rod
bore
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002311704A
Other languages
French (fr)
Inventor
Henrik Andersen
John Thrane Hansen
Lars Peter Klitmose
Preben Broskov Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk A/S
Henrik Andersen
John Thrane Hansen
Lars Peter Klitmose
Preben Broskov Nielsen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S, Henrik Andersen, John Thrane Hansen, Lars Peter Klitmose, Preben Broskov Nielsen filed Critical Novo Nordisk A/S
Publication of CA2311704A1 publication Critical patent/CA2311704A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
    • A61M2005/14573—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons with a replaceable reservoir for quick connection/disconnection with a driving system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M2005/31518—Piston or piston-rod constructions, e.g. connection of piston with piston-rod designed to reduce the overall size of an injection device, e.g. using flexible or pivotally connected chain-like rod members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31556—Accuracy improving means
    • A61M5/31558—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31571—Means preventing accidental administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31566—Means improving security or handling thereof
    • A61M5/31573—Accuracy improving means
    • A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
    • A61M5/31595—Pre-defined multi-dose administration by repeated overcoming of means blocking the free advancing movement of piston rod, e.g. by tearing or de-blocking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/01—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with manually mechanically or electrically actuated piston or the like
    • B05C17/0113—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with manually mechanically or electrically actuated piston or the like the piston rod being flexible or articulated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S128/00—Surgery
    • Y10S128/01—Motorized syringe

Abstract

In a syringe dosing mechanism a threaded spindle (1) and a nut (3) co-operates so that relative rotation thereof moves the nut (3) along the spindle (1). The nut (3) has two intersecting bores (12, 15). The first bore (15) has an inner thread (7) matching the outer thread (2) of the spindle (1) and the second bore (12) is smooth and fits slidingly over the spindle (1). The nut (3) is tiltable between a first and a second position. In the first position the threaded bore (15) is coaxial with the spindle (1) and in the second position the smooth bore (12) is coaxial with the spindle (1). The nut (3) is at a first side hinged to a piston rod (6)so that exertion of a force by the nut (3) on the piston rod (6) in a direction (10) by which an injection is performed will tilt said nut (3) into its first position. A piston withdrawal member acts at a second side of said nut diametrically opposite said first side so that the nut (3) is tilted to its second position when the withdrawal member applies a force (13) to said nut (3).

Description

TILTABLE NUT

This application is a Divisional of Application Ser. No. 2,294,638 filed Jane 15. 1998.
The invention relates to syringes for dosed injection of a medicine from an exchangeable car-tridge of the kind having a piston which is forced into a tubular cartridge to press out a dose of medicine corresponding to the movement of the piston, the syringe having a housing comprising a cartridge holder and a dosing mechanism by which a dose is set and sub-sequently injected by successively advancing a piston rod to press the piston into the car-tridge, said dosing mechanism comprising a threaded spindle and a nut member co-operating with the spindle so that by setting of a dose relative rotation of the spindle and the nut member will move the nut member along the spindle, the position of the nut member on the spindle defining how far the piston rod is advanced during the injection.
The spindle may be formed by the piston rod which may be provided with an outer thread.
When the cartridge is empty said piston rod projects into the cartridge in almost the total length thereof. To change the cartridge the piston rod must first be drawn out of the empty cartridge, and thereafter it must be brought back to its initial position in the dose setting part.
The last operation is made possible by locks getting unlocked when the empty cartridge is removed from the syringe, where after the piston rod may be pushed or screwed back to its initial position.
The release of said locking may be obtained either by bringing the inner thread of the nut member out of engagement with the spindle or by allowing a free relative rotation of the nut member and the spindle. When the locking is released the nut member, which have during the injections performed been moved to a position on the spindle corresponding to a fully advanced piston rod, may be moved along the spindle back to its position corresponding to a totally retracted piston rod.
By the free rotation of the nut member relative to the spindle the nut may be screwed back to its initial position corresponding to a fully retracted piston rod. However, the nut have to be rotated about 75 turns and this screwing may demand some handiness. This problem may be overcome by using threads with a high pitch and low friction which allows the spindle to rotate by itself when the nut is pressed in the axial direction of said spindle. Another solution is to use a nut member comprising at least two parts which may be pulled apart so that their threads are drawn out of engagement with the thread of the spindle when the nut is going to be returned to its initial position. However, this solution may cause problems when the parts are brought together again to engage the thread of the spindle as it may be difficult to obtain the correct synchronisation between the position of the nut member on the spindle and the scale indicating the dose set. Further, the engagement between the threads is dependent on tolerances which may cause wear which makes the settings inaccurate.
It is an object of the invention to provide a nut providing a good engagement with the spindle and the thread of which may easily be brought out of engagement with the thread of the spindle without involving parts which must be moved in relation to each other.
This is obtained by a syringe as described in the opening of this application using a nut which has two intersecting bores forming an angle with each other and of which a first bore has an inner thread matching the outer thread of the spindle and a second bore is smooth and fits slidingly over the thread of the spindle, the nut member being mounted to the piston rod tiltable between a first and a second position so that in the first position the threaded bore is coaxial with the spindle during dose setting and injection and in the second, position to which the nut is tilted when acted upon to withdraw the piston rod and move said nut member along the spindle the smooth bore is coaxial with the spindle.
According to a further broad aspect of the present invention there is provided a syringe having a housing which is comprised of a cartridge holder and a dosing mechanism by which a dose is set and subsequently injected by successively advancing a piston rod to press a piston into the cartridge. The dosing mechanism comprises a threaded spindle and a nut member co-operating with the spindle so that by setting of a dose relative rotation of the spindle and the nut member will move the nut member along the spindle. The position of the nut member on the spindle defines how far the piston rod is advanced during the injection. The syringe is characterized in that the nut has two intersecting bores forming an angle with 2a each other and of which a first bore has an inner thread matching the outer thread of the spindle and a second bore is smooth and fits slidingly over the thread of the spindle. The nut member is mounted to the piston rod tiltable between a first and a second position so that in the first position the threaded bare is coaxial with the spindle during dose setting and injection and in the second position to which the nut is tilted when acted upon to withdraw the piston rod and move the nut member along the spindle, the smooth bore is coaxial with i0 the spindle.
During normal use of the injection device the nut is held with its first bore coaxial with the spindle with the threaded parts of this first bore engaging the outer thread of the spindle.
This way the nut may be moved along the spindle when said spindle and the nut are rotated relative to each other. When it is requested to move the nut along the spindle without per-forming said relative rotation the nut is tilted on the spindle to bring it into a second angular position relative to the spindle in which angular position the second bore is coaxial with the spindle. In this angular position the nut may be displaced along the spindle with the smooth surface of the second bore sliding over the tops of the threads of the spindle. When the nut has been moved to a wanted position along the spindle, the nut is tilted back to its first an-gular position with the first bore coaxial with the spindle and the threaded parts of this first bore engaging the threads of the spindle.
In the following the invention is explained in further details with references to the drawing, wherein Figure 1 schematically shows a threaded spindle connected to a piston rod through a tiltable nut with a threaded and a smooth bare, the nut being in a first position with the thread of the bore engaging the thread of the spindle, and Figure 2 the spindle , nut and piston rod in figure 1 only with the nut tilted to a second position so that the spindle runs through the smooth walled bore.
In figure 1 a reciprocable and rotateable spindle 1 is provided with an outer thread 2 passing through a nut member 3 which has at a first side a journal 4 in which a pivot pin 5 on a piston rod 6 is journaled. The nut member 3 has two intersecting bores, a first bore coaxial with the spindle 1 in figure 1 and a second bore indicated by dotted lines 12 and intersecting the first bore forming an acute angle with this first bore. The first bore has an. inner thread 7 which in figure 1 engages the outer thread 2 of the spindle 1.
The spindle 1 forms a dose setting member of an injection device in which doses are set by rotating the spindle 1 about its axis. As the nut member is not rotateable, rotation of the spindle 2 will screw this spindle through the nut member 3. A dose is set by screwing the spindle in the direction shown by an arrow 8 and the set dose is injected by moving the spin-dle 1 without rotating it in the opposite direction shown by an arrow 9. The injection move-ment of the spindle will due to the engagement of the threads 2 and 7 of the spindle and the nut member, respectively, be transmitted to the nut member 3 and through the journal 4 and the pivot pin 5 further to the piston rod 6 which is moved in the direction indicated by an ar-row 10. By the injection movement of the spindle a force is exerted on the nut member 3 as indicated by an arrow 11 which force will try to rotate the nut member 3 about the pivot pin 5 in a direction which brings the threads of the spindle and the nut member in tighter en-gagement.
By successive dose settings and injections the piston rod 6 is moved to its extreme position in the direction indicated by the arrow 10, i. e. a piston upon which the piston rod 6 acts is moved all the way into a cartridge. By the successive dose settings the spindle 1 has been screwed by its full length through the nut member 3 in the direction indicated by the arrow 8.
To enable a changing of the cartridge the piston rod 6 has to be withdrawn and the nut member has to be moved from one end of the spindle 1 to the other. To enable such a movement the engagement between the threads of the spindle and the nut member has to be released. This is done by tilting the nut member to a second position so that the smooth walled bore of the nut member becomes coaxial with said spindle as shown in figure 2.
In figure 2 the piston rod 6 is omitted. To withdraw the piston rod the nut member must be drawn to the left in the figure 2. A drawing force is transmitted to the nut member from a withdrawal element which may be manually operated or automatically operated when a lid is opened to obtain access to an ampoule compartment. The not shown withdrawal element act by a force indicated by an arrow 13 on a second side of the nut member diametrically opposite said first side. The force indicated by the arrow 13 will together with a force indi-cated,by an arrow 14, originating from the resistance against withdrawal which the piston rod exerts on the nut member, exert a torque on the nut member in a plane defined by the inter-secting axis of the bores. This torque will draw the nut member to a second position in which the smooth walled bore is coaxial with the spindle 1 and keep the nut member in this tilted position as long as the withdrawing force is applied. With this second rotational position of the nut member 3 this nut member may be moved along the spindle as the top of the thread 2 of the spindle slides along the smooth wall of the smooth walled bore of the nut member 3.
The thread of the nut member is drawn out of engagement with the thread 2 of the spindle 1 as the threaded bore now is positioned as indicated by the dotted lines 15.
The nut member can be biased towards its first rotational position in which the threads of the spindle and the nut element are in engagement.

Claims (3)

1. A syringe having a housing comprising a cartridge holder and a dosing mechanism by which a dose is set and subsequently injected by successively advancing a piston rod to press a piston into the cartridge, said dosing mechanism comprising a threaded spindle and a nut member co-operating with the spindle so that by setting of a dose relative rotation of the spindle and the nut member will move the nut member along the spindle, the position of the nut member on the spindle defining how far the piston rod is advanced during the injection, characterised in that the nut has two intersecting bores forming an angle with each other and of which a first bore has an inner thread matching the outer thread of the spindle and a second bore is smooth and fits slidingly over the thread of the spindle, the nut member being mounted to the piston rod tiltable between a first and a second position so that in the first position the threaded bore is coaxial with the spindle during dose setting and injection and in the second position to which the nut is tilted when acted upon to withdraw the piston rod and move said nut member along the spindle the smooth bore is coaxial with the spindle.
2. Syringe according to claim 1, characterised in that the nut member at a first side is hinged to the piston rod so that exertion a force on the nut member in a direction by which the piston rod is pressed in a direction by which an injection is performed will tilt said nut member into its first position.
3. Syringe according to claim 2, characterised in that the a piston withdrawal member act on the nut member at a second side of said member diametrically opposite said first side so that the nut member is tilted to its second position when the a piston rod withdrawal force is applied to said nut member.
CA002311704A 1997-06-17 1998-06-15 Tiltable nut Abandoned CA2311704A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DK70697 1997-06-17
DK0706/97 1997-06-17
US5099397P 1997-06-19 1997-06-19
US60/050,993 1997-06-19
CA002294638A CA2294638C (en) 1997-06-17 1998-06-15 Dose setting device

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CA002294638A Division CA2294638C (en) 1997-06-17 1998-06-15 Dose setting device

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CA2311704A1 true CA2311704A1 (en) 1998-12-23

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CA002294638A Expired - Fee Related CA2294638C (en) 1997-06-17 1998-06-15 Dose setting device
CA002311704A Abandoned CA2311704A1 (en) 1997-06-17 1998-06-15 Tiltable nut

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CA002294638A Expired - Fee Related CA2294638C (en) 1997-06-17 1998-06-15 Dose setting device

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JP (2) JP2002514959A (en)
KR (2) KR100486374B1 (en)
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AU (1) AU746843B2 (en)
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CZ (1) CZ2000759A3 (en)
DE (1) DE69818997T2 (en)
DK (1) DK0991442T3 (en)
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IL (2) IL135079A0 (en)
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UA (2) UA52750C2 (en)
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ES2209153T3 (en) 2004-06-16
EP0991442B1 (en) 2003-10-15
AU8011198A (en) 1999-01-04
NO996239L (en) 2000-02-16
UA52750C2 (en) 2003-01-15
DE69818997T2 (en) 2004-09-09
CN1266720A (en) 2000-09-20
IL133250A (en) 2004-03-28
CN1165350C (en) 2004-09-08
CZ2000759A3 (en) 2000-08-16
WO1998057688A1 (en) 1998-12-23
HUP0002162A3 (en) 2001-02-28
PL337461A1 (en) 2000-08-14
JP2002514959A (en) 2002-05-21
NO20001205D0 (en) 2000-03-08
BR9810039A (en) 2000-09-05
DE69818997D1 (en) 2003-11-20
NO20001205L (en) 1999-12-17
CA2294638A1 (en) 1998-12-23
ZA985248B (en) 1999-01-20
NO996239D0 (en) 1999-12-16
PL188772B1 (en) 2005-04-29
KR20040004435A (en) 2004-01-13
ZA985249B (en) 1999-03-15
CN1260727A (en) 2000-07-19
CA2294638C (en) 2007-08-14
IL135079A0 (en) 2001-05-20
ATE251925T1 (en) 2003-11-15
US6796970B1 (en) 2004-09-28
EP0991442A1 (en) 2000-04-12
HU222557B1 (en) 2003-08-28
DK0991442T3 (en) 2004-01-26
JP2001009033A (en) 2001-01-16
KR100486374B1 (en) 2005-04-29
KR20010013863A (en) 2001-02-26
IL133250A0 (en) 2001-04-30
HUP0002162A2 (en) 2000-10-28
UA54541C2 (en) 2003-03-17
RU2200588C2 (en) 2003-03-20
AU746843B2 (en) 2002-05-02

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