Antimicrobial Resistance and Virulence Common MechanismsEtienne Giraud, Ivan Rychlik, Axel Cloeckaert Frontiers Media SA, Jun 1, 2017 Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the spread of clones combining multiple antibiotic resistance and a high virulence level is an increasing problem. It was previously described how mutation-driven or horizontally acquired resistance mechanisms can also have effects on virulence. It was also reported that mobile genetic elements often carry both resistance determinants and virulence-modulating genes, which favors the co-selection of both traits. In the present volume, we present a collection of articles which document additional aspects of the interactions between antimicrobial resistance and virulence in bacteria, and describe their potential therapeutic consequences. |
Contents
Antimicrobial Resistance and Virulence Common Mechanisms | 5 |
Multidrug Efflux Pumps at the Crossroad between Antibiotic Resistance and Bacterial Virulence | 8 |
PSMMecA Virulence Determinant that Connects Transcriptional Regulation Virulence and Antibiotic Resistance in Staphylococci | 22 |
SubMIC Tylosin Inhibits Streptococcus suis Biofilm Formation and Results in Differential Protein Expression | 30 |
Absence of Protoheme IX Farnesyltransferase CtaB Causes Virulence Attenuation but Enhances Pigment Production and Persister Survival in MRSA | 39 |
Polyphosphate Kinase Mediates Antibiotic Tolerance in Extraintestinal Pathogenic Escherichia coli PCN033 | 53 |
The Small Colony Variant of Listeria monocytogenes Is More Tolerant to Antibiotics and Has Altered Survival in RAW 2647 Murine Macrophages | 63 |
Carriage of ExtendedSpectrum BetaLactamasePlasmids Does Not Reduce Fitness but Enhances Virulence in Some Strains of Pandemic E coli Lineages | 74 |
Fitness Cost of Fluoroquinolone Resistance in Clinical Isolates of Pseudomonas aeruginosa Differs by Type III Secretion Genotype | 86 |
Virulence and Genomic Feature of Multidrug Resistant Campylobacter jejuni Isolated from Broiler Chicken | 98 |
Is Quorum Sensing Interference a Viable Alternative to Treat Pseudomonas aeruginosa Infections? | 112 |
PA3297 Counteracts Antimicrobial Effects of Azithromycin in Pseudomonas aeruginosa | 119 |
The New Generation of Hydantoin BasedModulators to Improve Antibiotic Activity | 131 |
Back cover | 139 |
Common terms and phrases
acid AcrAB activity Agents Chemother analysis antibiotic resistance antimicrobial resistance APA3297 mutant assay azithromycin bacterial Bacteriol biofilm formation Biol biosynthesis Campylobacter jejuni cells CFU/ml chicken Clin clinical isolates colony compared compounds concentrations ctaB mutant cultures effect efflux pumps encoding erythromycin ESBL-plasmid Escherichia coli exoS exoU strains expression levels Figure fitness costs fluoroquinolone FQ-resistance genetic genome gentamicin growth helicase Immun increased incubated infection inhibit involved jejuni isolates Kaito levofloxacin Listeria monocytogenes macrolide macrophage mechanisms membrane protein metabolism MexAB-OprM Microbiol Microbiology motility multidrug efflux pumps multidrug resistance mutant overexpression parC parent strain pathogen peptide persister formation phenotype pigment production planktonic plasmid plates PLoS ppk mutant Pseudomonas aeruginosa quorum sensing regulation resistance and virulence ribosome role rRNA SCV E18 sequence Staphylococcus aureus stationary phase survival susceptibility target tazobactam transcriptional treatment tylosin virulence factors Wang wild type Zhang