New Approaches for the Discovery of Pharmacologically-Active Natural CompoundsJosé L. Medina-Franco A major source of active compounds, natural products from different sources supply a large variety of molecules that have been approved for clinical use or used as the starting points of optimization programs. This book features nine papers (eight full articles and one review paper) written by more than 45 scientists from around the world. These papers illustrate the development and application of a broad range of computational and experimental techniques applied to natural product research. On behalf of the contributors to the book, our hope is that the research presented here contributes to advancements in the field, and encourages multidisciplinary teams, young scientists, and students to further advance in the discovery of pharmacologically-active natural compounds |
Common terms and phrases
acid alpine grassland Alzheimer’s Alzheimer’s disease amentoflavone analysis antioxidant approved drugs atoms Available online binding BIOFACQUIM Biol biological brain BRD4 bromodomain Calceolaria Calceolarioside catalytic cells characterization Chem chemical space Chen cholestasis compound 1 inhibits compound database constitutive proteasome CrossRef CrossRef][PubMed CTL activity curcumin curcumin-loaded cyclodextrin diversity DmAChE docking scores docking studies drug discovery effect enzymes evaluated experimental expression Figure fingerprints fisetin flavonoids ginsenoside F1 glycosylated grassland hAChE immunoproteasome subunits induced inflammatory inhibitors insecticides interaction kinase ligand lipid nanoparticles MACCS keys macrophages Medina-Franco metabolic Mexico mice modulation molecular docking molecular dynamics molecules multitarget nanoparticles naringenin natural products ND ND novel NP-likeness peptide Pharm phenylethanoid glycosides PLFAs PLGA potential protein PubMed quercetin receptor relative abundance reported residues RMSD scaffold selected showed simulation soil solubility squalene structure Table Tibetan Plateau treatment tyrosinase values verbascoside vitro vivo model Wang Zhang