Micro- and Nanofluidics for Bionanoparticle AnalysisYong Zeng, Xuanhong Cheng Bionanoparticles such as microorganisms and exosomes are recoganized as important targets for clinical applications, food safety, and environmental monitoring. Other nanoscale biological particles, includeing liposomes, micelles, and functionalized polymeric particles are widely used in nanomedicines. The recent deveopment of microfluidic and nanofluidic technologies has enabled the separation and anslysis of these species in a lab-on-a-chip platform, while there are still many challenges to address before these analytical tools can be adopted in practice. For example, the complex matrices within which these species reside in create a high background for their detection. Their small dimension and often low concentration demand creative strategies to amplify the sensing signal and enhance the detection speed. This Special Issue aims to recruit recent discoveries and developments of micro- and nanofluidic strategies for the processing and analysis of biological nanoparticles. The collection of papers will hopefully bring out more innovative ideas and fundamental insights to overcome the hurdles faced in the separation and detection of bionanoparticles. |
Common terms and phrases
allow analysis analytical angle applied assay authors blood samples bottom calculated cancer carbon CD45neg/EpCAMneg cells cell isolation Chem chemical cigarette smoke coating collection concentration conductive continuous CrossRef CTCs described detection detector developed diameter dielectric diffraction digital microfluidic DMF chip droplet effect electrical electrode enrichment Equation evaluated experimental experiments fabrication Figure flow rate fluid fluorescence focusing force frequency hydrophobic increased inlet Lab Chip layer magnetic field magnetic force manipulation material measurement membrane method microchannel microfluidic chip microfluidic system microscopic mixing nanoparticles observed obtained ODEP operation p-CMF device p-DMF paper channel paper-based microfluidic devices parameters particles patterning PDMS performance permanent magnet permeation printing programmable proposed PubMed resistance channel respectively sample sensing sensitivity sensor separation shown in Figure shows solution spore structure surface synthesis techniques tests transport viral voltage width