Manipulation of the cellular microbicidal response and endocytic dynamic by pathogens membrane factors

Front Cover
Benjamin Coiffard, Philippe Soubeyran, Eric Ghigo
Frontiers Media SA, Jul 10, 2015 - Infectious and parasitic diseases - 81 pages

Intracellular pathogens, such as bacteria and parasites, have evolved specialized mechanisms to survive and replicate in their host, leading to disorders and diseases. The principle of these mechanisms is to reprogram the microbicidal cell function in order to disable the host cells defence that aims to control and eliminate foreign invaders. Devoid of their defence, cells become permissive to pathogens invasion.

The aim of this Research Topic is to highlight and cover recent understanding of mechanisms and molecules used by pathogens to interfere with the microbicidal function of cells. This Research Topic will focus on the reprogramming of the cellular dynamics, the immune response, the phagolysosome biogenesis and the signal transduction pathways bypathogens. Special attention will be made on non-proteic virulence factors, however this Research Topic is not restricted to non-proteic virulence factors.

 

Selected pages

Contents

Manipulation of the cellular microbicidal response and endocytic dynamic by pathogens membrane factors
5
a booster for new advances in hostpathogen interactions
7
What RNAi screens in model organisms revealed about microbicidal response in mammals?
11
Hemocytes from Pediculus humanus humanus are hosts for human bacterial pathogens
18
Alterations of host cell ubiquitination machinery by pathogenic bacteria
24
The complexity of Rab5 to Rab7 transition guarantees specificity of pathogen subversion mechanisms
31
Playing hideandseek with host macrophages through the use of mycobacterial cell envelope phthiocerol dimycocerosates and phenolic glycolipids
35
Manipulation of the endocytic pathway and phagocyte functions by Mycobacterium tuberculosis lipoarabinomannan
42
Coxiella burnetii lipopolysaccharide blocks p38αMAPK activation through the disruption of TLR2 and TLR4 association
51
how to establish structureactivity relationships for this highly complex and multifunctional glycoconjugate?
57
the lessons from gene expression analysis
64
defective responsiveness to Coxiella burnetii and Brucella abortus
72
Back Cover
82
Copyright

Common terms and phrases

abortus activation Amara apoptosis autophagy bacteria Biol BLPs BMDMs body lice Cellular and Infection cfu 0 cfu Chem complex Coxiella burnetii cytokines cytoskeleton DC-SIGN dDCs dendritic cells distribution or reproduction domain Drosophila effector elegans endosomes expression factor Figure France function genes Gilleron Gorvel granuloma granuloma cells granuloma formation hemocytes host cell human macrophages immune response immune system Immunol induced INFECTION MICROBIOLOGY inflammatory inhibition innate immune interactions intracellular involved kinase ligase lipid lipoarabinomannan lipophosphoglycan Listeria M.tb macrophages mammalian ManLAM mannose MAPK Marseille mechanisms membrane mice microarray microbes microbicidal Microbiol moDCs modulated molecular molecules Mycobacterium tuberculosis Nigou parasite pathogens PBMCs PGRPs phagocytes phagocytosis phagosome phagosome maturation planarians PLoS pro-inflammatory promastigote protein prowazekii Q fever quintana Rab5 Rab7 Raoult recruitment replication RNAi screen role Salmonella signaling pathway specific structure target tion TLR-2 and TLR-4 Toll-like receptor transcriptional Turco ubiquitin up-modulated virulence vLPS zebrafish

Bibliographic information

TitleManipulation of the cellular microbicidal response and endocytic dynamic by pathogens membrane factors
Frontiers Research Topics
Editors Benjamin Coiffard, Philippe Soubeyran, Eric Ghigo
PublisherFrontiers Media SA, 2015
ISBN2889196097, 9782889196098
Length81 pages
  
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