Muscle-Tendon-Innervation Unit: Degeneration and Aging - Pathophysiological and Regeneration MechanismsLuciano Merlini, Cesare Faldini, Paolo Bonaldo Frontiers Media SA, Feb 24, 2017 Aging is characterized by progressive deterioration of walking ability. This function loss has multiple causes including central and peripheral nerve dysfunction, loss of muscle mass and strength, as well as joints and bone alterations. Muscle-tendon unit and its innervation has a pivotal role in motor function performance that can be disrupted by overuse degeneration and aging. Research has shown that overuse degeneration and aging also share some pathophysiological mechanisms including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and modification of signalling and stress response pathways. This Research Topic is intended to bring together basic researchers and clinicians working in the area of neuroscience, aging, sarcopenia and orthopaedics in human and in animal models. The aim of this cross-fertilization is to accelerate our understanding of the mechanisms involved in aging and degeneration of the muscle-tendon unit and its innervation and to explore the therapeutic potential of pharmacological and physical therapy interventions. |
Contents
MuscleTendonInnervation Unit Degeneration and AgingPathophysiological and Regeneration Mechanisms | 5 |
Role of Endolysosomes in Skeletal Muscle Pathology Observed in a CholesterolFed Rabbit Model of Alzheimers Disease | 7 |
A Muscle Disease Due to Dysregulated Proprioceptive Polysynaptic Reflex Arch | 20 |
A Review of the Current Evidences | 24 |
A Potential Target for Low Back Pain | 35 |
A Possible Alternative | 38 |
Literature Review | 49 |
The Role of Detraining in Tendon Mechanobiology | 54 |
Fibrillins in Tendon | 62 |
Activation of EphA4 and EphB2 Reverse Signaling Restores the AgeAssociated Reduction of SelfRenewal Migration and Actin Turnover in Human ... | 69 |
Patterns of AgeAssociated Degeneration Differ in Shoulder Muscles | 79 |
The Efficacy is Reduced in 60years Old People Compared to Young and MiddleAge Individuals | 89 |
Tendon Extracellular Matrix Alterations in Ullrich Congenital Muscular Dystrophy | 96 |
Back cover | 105 |