Chronic Rhinosinusitis and Concomitant Medical DisordersDavid A. Gudis It is with great pleasure that we present to you this Special Issue of Medical Sciences. In this issue, we present a comprehensive and contemporary review of the medical comorbidities that contribute to chronic rhinosinusitis, and, conversely, how our interventions as otolaryngologists can impact those systemic conditions. Our understanding of chronic rhinosinusitis has evolved tremendously over the last two decades. As we have learned, chronic rhinosinusitis—a chronic inflammatory condition of the nasal cavity and paranasal sinuses—is often a local inflammatory response to a systemic or mucosal disorder. The underlying systemic medical conditions not only influence the presentation and diagnosis of chronic rhinosinusitis, but also modify the patients’ response to medical and surgical interventions. Chronic rhinosinusitis associated with cystic fibrosis, for example, is a disorder quite distinct from that associated with aspirin-exacerbated respiratory disease. A clear understanding of the nuances that distinguish these unique and challenging disorders is critical for the practicing otolaryngologist. Equally important, however, is a clear understanding of the powerful benefits that our interventions as otolaryngologists can have for our patients’ rhinologic and systemic health. Knowing that our rhinologic interventions might spare an asthma patient a trip to an emergency room or reduce lung infections in a cystic fibrosis patient makes this a very exciting time to be a rhinologist. We hope you enjoy this Special Issue of Medical Sciences. |
Common terms and phrases
activation adenoid adenoidectomy adults AERD AERD patients allergic rhinitis Allergy Clin analysis aspirin aspirin-exacerbated respiratory disease associated asthma authors cells CF patients challenge chronic rhinosinusitis clinical compared contribute correlated CrossRef CrossRef][PubMed CRSwNP cystic fibrosis decreased demonstrated desensitization diagnosis dose effect efficacy endoscopic sinus surgery eosinophils et al evaluated evidence exacerbations factors Figure findings Forum Allergy Rhinol function ibuprofen Immunol improved increased induce inflammation inflammatory leukotriene levels lung mast cells measured mechanisms mice mucosal nasal polyposis nasal polyps obstruction Otolaryngol outcomes paranasal sinuses pathway PCRS pediatric performed present PubMed pulmonary randomized reactions recent receptor reduce reported response role saline scores sensitivity severe showed shown significant sinonasal sinuses specific splenocytes SPLhEos suggests surgical symptoms systemic testing therapy tissue topical transfer treat treatment trial upper weeks