Challenging the Functional Connectivity Disruption in Neurodegenerative Diseases: New Therapeutic Perspectives through Non-Invasive Neuromodulation and Cutting-Edge TechnologiesGiancarlo Zito, Takashi Hanakawa, Luca Berdondini, Lorenzo Masia, Lorenzo Natale Frontiers Media SA, Oct 5, 2018 The neurorehabilitation field is increasingly focused on understanding how to efficiently revert the effects that acute (i.e., stroke or traumatic brain injury) or chronic (i.e., neurodegenerative diseases) insults play either on small or large-scale networks, encompassing motor, sensory and cognitive domains. The link between the disrupted neuronal pulse generators and their effectors is being re-shaped through a wide scenario that embraces biorobotics, robot-aided rehabilitation, non-invasive neurostimulation, nanoprosthetics and neuroengineering. For the past decade and at an amazing speed, large investments and efforts allowed enthusiastic and only apparently heterogeneous researchers to borrow theories from neurophysiology, pharmacology, physics and quantum mechanics in order to generate together highly sophisticated tools that restore, resemble or even substitute the basic biological architecture. The idea of actually reverting weakened functions and/or replacing the faulty parts either of the human body or the central and peripheral nervous system is becoming a new reality, opening a fascinating era in this field. In this Research Topic, several researchers showed how the above principles became reality, from theory to the bedside of patients, providing full explanations of the whole mechanistic processes and how they were implemented, up to the final stage. |
Contents
Challenging the Functional Connectivity Disruption in Neurodegenerative Diseases New Therapeutic Perspectives Through Noninvasive Neuromodul... | 6 |
An Overlooked Resource in Animal Models | 9 |
A Review of Evidence from Visual Evoked Potentials and Diffusion Magnetic Resonance Imaging | 26 |
fMRI Effects of Different Stimuli | 40 |
Interhemispheric RestingState Functional Connectivity Predicts Severity of Idiopathic Normal Pressure Hydrocephalus | 53 |
Impairment of LongTerm Plasticity of Cerebellar Purkinje Cells Eliminates the Effect of Anodal Direct Current Stimulation on VestibuloOcular Refle... | 63 |
Effect of Error Augmentation on Brain Activation and Motor Learning of a Complex Locomotor Task | 72 |
The Emergent Role of Virtual Reality in the Treatment of Neuropsychiatric Disease | 88 |
Reestablishment of Inhibitory Neural Network Tonus | 92 |
Therapeutic Use of Noninvasive Brain Stimulation in Dystonia | 102 |
A TwoCase Study | 108 |
A Challenging Therapeutic Approach | 118 |
MRIGuided Regional Personalized Electrical Stimulation in Multisession and Home Treatments | 129 |
Back Cover | 142 |