Assessing Prenatal and Neonatal Gonadal Steroid Exposure for Studies of Human Development: Methodological and Theoretical Challenges Rebecca Christine Knickmeyer, Marsha L. Davenport, Bonnie Auyeung Frontiers Media SA, Jul 28, 2015 - Diseases of the endocrine glands. Clinical endocrinology - 80 pages There is extensive evidence from animal models that gonadal steroids, produced in fetal and neonatal life, act on the developing organism to produce sex differences far beyond the reproductive system. That early gonadal steroid exposure also plays an important role in human development is supported by studies of individuals with disorders of sex determination and differentiation. It is much less clear whether normal variation in gonadal steroid exposure predicts sexually dimorphic health outcomes or within-sex variation. This is largely due to challenges related to the assessment of gonadal steroid exposure in the developing fetus and neonate. |
Contents
methodological and theoretical challenges | 5 |
accuracy biological interpretation and applications to understanding human behavioral development | 8 |
Dispatches from the interface of salivary bioscience and neonatal research | 17 |
4D a biomarker for prenatal sex steroids and adult sex steroids in challenge situations | 25 |
4D is related to the number of CAG repeats in the androgen receptor gene | 30 |
A comparison of anthropometric metabolic and reproductive characteristics of young adult women from oppositesex and samesex twin pairs | 36 |
Spreading the clinical window for diagnosing fetalonset hypogonadism in boys | 42 |
identifying and distinguishing the impact of steroid hormones | 56 |
Postnatal testosterone concentrations and male social development | 60 |
Environmental and genetic contributors to salivary testosterone levels in infants | 66 |