Significance of antigen and epitope specificity in tuberculosisJuraj Ivanyi, Tom H.M. Ottenhoff Dissection of the specificity of host immune responses following infection with Mycobacterium tuberculosis is essential for designing effective vaccination and diagnostic biomarkers as well as for better understanding of immunopathogenesis of active tuberculosis. The articles in this volume of the Topics in Microbial Immunology review the significance of this area of research from both experimental models and clinical surveys. This includes T cell recognition of MHC permissive epitopes, use of algorithms for genome-based prediction of immunodominant epitopes, evaluation of candidate antigens/epitopes and adjuvants for vaccination and immunodiagnosis. Future research strategies indicate the need for better understanding of the relationship between epitope specificity and the phenotype of responding T cells and search for biomarkers with a capacity to discriminate and predict the change from latent infection to active disease. These research avenues have important potentials for improving the prevention and control of tuberculosis. |
Contents
Significance of antigen and epitope specificity in tuberculosis | 5 |
Function and potentials of M tuberculosis epitopes | 7 |
Definition of CD4 immunosignatures associated with MTB | 18 |
Innovative strategies to identify M tuberculosis antigens and epitopes using genomewide analyses | 25 |
Functional signatures of human CD4 and CD8 T cell responses to Mycobacterium tuberculosis | 33 |
biomarkers of protection disease and response to treatment | 46 |
The immunodominant Tcell epitopes of the mycolyltransferases of the antigen 85 complex of M tuberculosis | 50 |
Role of fused Mycobacterium tuberculosis immunogens and adjuvants in modern tuberculosis vaccines | 61 |
innovations on an old vaccine Scope of BCG strains and strategies to improve longlasting memory | 70 |
The Tcell response to lipid antigens of Mycobacterium tuberculosis | 79 |
Toward understanding the essence of posttranslational modifications for the Mycobacterium tuberculosis immunoproteome | 88 |
The PGRS domain from PE_PGRS33 of Mycobacterium tuberculosis is target of humoral immune response in mice and humans | 98 |
Immunogenicity of 60 novel latencyrelated antigens of Mycobacterium tuberculosis | 107 |