Developments in Bovine Immunology - An Integrated ViewKieran G. Meade The world’s population is predicted to hit 9 Billion by 2050, and with it food demand is predicted to increase substantially. The World Bank estimates that cereal and meat production needs to increase by 50% and 85% respectively between 2000 and 2030 to meet demand, putting serious pressure on the global agricultural industry. Critical to meeting this demand for food are mechanisms to reduce the incidence of animal disease. With in excess of 1.3 billion cattle globally, the total cost of infectious diseases is difficult to estimate. However in North America alone, the cost is predicted to be $18 billion annually. Non-infectious diseases also account for another major impediment to the production capacity and welfare of animals as well as the economic sustainability of farming. However animal diseases have implications that spread far beyond the farm gate. Infectious agents can also contaminate the food chain, and potentially affect human health. |
Contents
Advances in bovine immunology new tools and new insights to tackle old foes | 5 |
RNAseq transcriptional profiling of peripheral blood leukocytes from cattle infected with Mycobacterium bovis | 7 |
Analysis of the bovine monocytederived macrophage response to mycobacterium avium subspecies paratuberculosis infection using RNAseq | 19 |
Key hub and bottleneck genes differentiate the macrophage response to virulent and attenuated Mycobacterium bovis | 33 |
Comparative functional genomics and the bovine macrophage response to strains of the Mycobacterium genus | 46 |
The single intradermal cervical comparative test interferes with Johnes disease ELISA diagnostics | 60 |
role of signaling pathways and negative regulators | 68 |
The role of microRNAs in bovine infection and immunity | 78 |
The contribution of the maternal immune system to the establishment of pregnancy in cattle | 85 |
frontiers in immunogenetics | 93 |