Ion Channel Trafficking and Cardiac ArrhythmiasMarcel A.G. van der Heyden, Brian P. Delisle, Baoxin Li, Hugues Abriel Frontiers Media SA, Dec 6, 2018 A well-adjusted expression of cardiac ion channels at the sarcolemma is of crucial importance for normal action potential formation and thus cardiac function. The cellular processes that transport channel proteins from the endoplasmic reticulum towards specified regions on the sarcolemmal membrane, and subsequently take them from the plasma membrane to the protein degradation machinery are commonly known as trafficking. The research field recognizes that aberrant channel trafficking stands at the basis of many congenital and acquired arrhythmias. The collection of papers in this eBook provides state-of-the-art insight into the world of ion channel trafficking research. |
Contents
Ion Channel Trafficking and Cardiac Arrhythmias | 5 |
Control of Ion Channel Density as a Target for Arrhythmias? | 7 |
Ankyrins and Spectrins in Cardiovascular Biology and Disease | 13 |
VoltageGated Sodium Channel β1β1B Subunits Regulate Cardiac Physiology and Pathophysiology | 20 |
An Autophagic Perspective | 31 |
Development of a HighThroughput Flow Cytometry Assay to Monitor Defective Trafficking and Rescue of Long QT2 Mutant hERG Channels | 40 |
Visualizing MutationSpecific Differences in the TraffickingDeficient Phenotype of Kv111 Proteins Linked to Long QT Syndrome Type 2 | 50 |
Kir21Nav15 Channel Complexes Are Differently Regulated than Kir21 and Nav15 Channels Alone | 61 |
KV43 Expression Modulates NaV15 Sodium Current | 77 |
Four TRPM4 Cation Channel Mutations Found in Cardiac Conduction Diseases Lead to Altered Protein Stability | 90 |
Golgin97 Targets Ectopically Expressed Inward Rectifying Potassium Channel Kir21 to the transGolgi Network in COS7 Cells | 101 |
Cx43 Isoform GJA120k Promotes Microtubule Dependent Mitochondrial Transport | 110 |
Back Cover | 122 |
Common terms and phrases
Abriel action potential ankyrin ankyrin-B antiarrhythmic antibodies arrhythmic assay associated atrial fibrillation autophagy binding Biol Brugada syndrome C-terminal Ca2+ CaMKII cardiac arrhythmia Cardiol cardiomyocytes Cardiovasc cell surface cells expressing cells transfected cellular Chem Circ co-localization complexes confocal cotransfected decreased degradation density disease drugs Figure flow cytometry function gene glycosylated Golgi GRIP domain heart HEK293 cells hERG hERG channels human images immunoprecipitation immunostaining immunostaining pattern inactivation increased incubated inhibition inhibitor interaction intracellular ion channel ion channel trafficking IRES-GFP isoforms KCND3-IRES-GFP kinase Kir2.1 channels Kv11.1 protein long QT syndrome LQT2 mutations LQTS Matamoros mechanisms mice microtubule mitochondrial modulation Mohler Molecular mutations Nav1.5 channels NaV1.5 current nocodazole overexpression pathway phenotype Physiol plasma membrane potassium channel proteasome protein expression protein immunostaining regulation repolarization repolarization velocity role SCN1B signal spectrin studies subunits surface expression targeting trafficking-deficient transfected TRPM4 variants ventricular myocytes voltage-gated sodium channels Zhou