Minding Glial Cells in the Novel Understandings of Mental IllnessTakahiro A. Kato, Aye M. Myint, Johann Steiner Frontiers Media SA, May 3, 2017 Traditionally, abnormalities of neurons and neuronal networks including synaptic abnormalities and disturbance of neurotransmitters have dominantly been believed to be the main causes of psychiatric disorders. Recent cellular neuroscience has revealed various unknown roles of glial cells such as astrocytes, oligodendrocytes and microglia. These glial cells have proved to continuously contact with neurons /synapses, and have been shown to play important roles in brain development, homeostasis and various brain functions. Beyond the classic neuronal doctrine, accumulating evidence has suggested that abnormalities and disturbances of neuron-glia crosstalk may induce psychiatric disorders, while these mechanisms have not been well understood. This Research Topic of the Frontiers in Cellular Neuroscience will focus on the most recent developments and ideas in the study of glial cells (astrocytes, oligodendrocytes and microglia) focusing on psychiatric disorders such as schizophrenia, mood disorders and autism. Not only molecular, cellular and pharmacological approaches using in vitro / in vivo experimental methods but also translational research approaches are welcome. Novel translational research approaches, for example, using novel techniques such as induced pluripotent stem (iPS) cells, may lead to novel solutions. We believe that investigations to clarify the correlation between glial cells and psychiatric disorders contribute to a novel understanding of the pathophysiology of these disorders and the development of effective treatment strategies. |
Contents
Minding Glial Cells in the Novel Understandings of Mental Illness | 7 |
Glial Involvement Beyond the Glue | 10 |
Reduced density of glutamine synthetase immunoreactive astrocytes in different cortical areas in major depression but not in bipolar I disorder | 30 |
Oligodendrocyte and Interneuron Density in Hippocampal Subfields in Schizophrenia and Association of Oligodendrocyte Number with Cognitive D... | 42 |
Serum S100B Protein is Specifically Related to White Matter Changes in Schizophrenia | 55 |
Serum S100B Is Related to Illness Duration and Clinical Symptoms in SchizophreniaA MetaRegression Analysis | 69 |
Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders | 80 |
a novel translational research tool for psychiatric disorders | 89 |
Impairment of Oligodendroglia Maturation Leads to Aberrantly Increased Cortical Glutamate and AnxietyLike Behaviors in Juvenile Mice | 151 |
Proteomics Research in Schizophrenia | 162 |
insights for schizophrenia | 184 |
Effect of MK801 and Clozapine on the Proteome of Cultured Human Oligodendrocytes | 194 |
Clozapine promotes glycolysis and myelin lipid synthesis in cultured oligodendrocytes | 208 |
Microglial intracellular Ca2+ signaling as a target of antipsychotic actions for the treatment of schizophrenia | 219 |
Implications of DNA Methylation in Glial Cells | 224 |
Potential primary roles of glial cells in the mechanisms of psychiatric disorders | 232 |
Changes in Astroglial Markers in a Maternal Immune Activation Model of Schizophrenia in Wistar Rats are Dependent on Sex | 94 |
polycytidylic acid does not evoke microglial cell activation in the embryo | 105 |
Maternal immune activation evoked by polyinosinic polycytidylic acid does not evoke microglial cell activation in the embryo | 119 |
Quetiapine Inhibits Microglial Activation by Neutralizing Abnormal STIM1Mediated Intercellular Calcium Homeostasis and Promotes Myelin Repai... | 122 |
Exploring the role of microglia in mood disorders associated with experimental multiple sclerosis | 133 |
Longterm NMDAR antagonism correlates reduced astrocytic glutamate uptake with anxietylike phenotype | 143 |
Astrocytes and Microglia and Their Potential Link with Autism Spectrum Disorders | 243 |
pharmacological significance as a drug target | 251 |
Possible role of glial cells in the relationship between thyroid dysfunction and mental disorders | 263 |
Understanding the role of P2X7 in affective disordersare glial cells the major players? | 270 |
Back Cover | 276 |