Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative DiseasesYu Tang, Isidre Ferrer Frontiers Media SA, 2018 Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflammatory phenotypes to immunosuppressive phenotypes. Therefore, targeting microglial polarization holds great promise for the treatment of neurodegeneration. This eBook focuses on the potential mechanisms of microglial polarization that are critically associated with a broad spectrum of neurodegenerative diseases, including Parkinson’s disease (PD), Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), Traumatic brain injury (TBI), glaucomatous neurodegeneration and prion diseases. This topic also involves the therapeutic targeting of microglial polarization by nutritional and pharmacological modulators. Moreover, this topic describes advanced technologies employed for studying microglia. Age-related changes in microglia functions are also discussed. Overall, this eBook provides comprehensive understandings of microglial polarization in the course of neurodegeneration, linking with aging-related microglial alterations and technologies developed for microglial studies. Hopefully, it will also give comprehensive insights into various aspects of therapeutic treatment for neurodegeneration, through targeting microglial polarization. |
Contents
Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases | 7 |
Targeting Microglial Activation States as a Therapeutic Avenue in Parkinsons Disease | 10 |
Mild Inflammatory Profile without Gliosis in the cRel Deficient Mouse Modeling a LateOnset Parkinsonism | 28 |
Acute Hypoxia Induced an Imbalanced M1M2 Activation of Microglia through NFB Signaling in Alzheimers Disease Mice and WildType Littermates | 38 |
TREM2DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway | 50 |
Mechanisms and Therapeutic Approaches | 59 |
Microglial Activation in the Pathogenesis of Huntingtons Disease | 69 |
Microglial Activation in Traumatic Brain Injury | 78 |
Modulation of Microglial Activity by RhoKinase ROCK Inhibition as Therapeutic Strategy in Parkinsons Disease and Amyotrophic Lateral Sclerosis | 167 |
Role of Atypical Chemokine Receptors in Microglial Activation and Polarization | 175 |
Implications for Aging and Neurodegeneration | 183 |
Lessons Learned about Neurodegeneration from Microglia and Monocyte Depletion Studies | 199 |
A Combination of Ex vivo Diffusion MRI and Multiphoton to Study MicrogliaMonocytes Alterations after Spinal Cord Injury | 213 |
What MicrogliaSpecific Transcriptomic Studies Taught and did Not Teach Us | 225 |
Aging MicrogliaPhenotypes Functions and Implications for AgeRelated Neurodegenerative Diseases | 243 |
Key AgingAssociated Alterations in Primary Microglia Response to BetaAmyloid Stimulation | 252 |
Curcumin Protects against Ischemic Stroke by Titrating Microglia Macrophage Polarization | 98 |
Alzheimers Disease Parkinson and Glaucoma | 108 |
A Paradigm of Functional Diversity | 129 |
Pharmacological Modulation of Functional Phenotypes of Microglia in Neurodegenerative Diseases | 142 |
Nutritional and Pharmacological Strategies to Regulate Microglial Polarization in Cognitive Aging and Alzheimers Disease | 152 |
Emerging Roles of GliaNeuron and GliaStemNeuroprogenitor Crosstalk for Dopaminergic Neurorestoration in Aged Parkinsonian Brain | 275 |
Studies on Colony Stimulating Factor Receptor1 and Ligands Colony Stimulating Factor1 and Interleukin34 in Alzheimers Disease Brains and Huma... | 295 |
Recent Advances in the Study of BipolarRodShaped Microglia and their Roles in Neurodegeneration | 310 |
Back Cover | 326 |