DNA Replication StressRobert M. Brosh Jr. This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging. As Guest Editor for this IJMS |
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activity addition aging analysis associated base binding Biol breaks cancer cause cell cycle cellular senescence changes checkpoint Chem chromatin chromosome complex containing CrossRef CrossRef][PubMed detected disease DNA damage DNA damage response DNA polymerase DNA repair DNA replication domain DSBs effects endonuclease et al EXO1 expression factors Figure function gene Genet genome GPCR helicase homologous human important increased indicating induced inhibition initiation instability interaction involved kinase leads lesions levels mechanisms mediated molecular multiple mutations Nature neurons normal nuclear Nucleic Acids Res observed origins oxidative pathway patients PCNA phase phosphorylation prevent progression promotes protein PubMed receptor recombination recruitment regions regulation repeat replication fork replication stress response REV3L role senescence sequence showed shown signaling specific SSB end resection ssDNA stability stalled strand structures studies suggest syndrome synthesis transcription treatment ubiquitin Wang