Myofilament Function in Health and DiseaseJulien Ochala Frontiers Media SA, May 22, 2017 The present E-book, consisting of a compilation of original articles and reviews, presents how myofilaments are regulated in cardiac and skeletal muscles and trigger contraction. Additionally, this E-book gives insights into their dysregulation in a number of muscle disorders. |
Contents
A new paradigm for muscle contraction | 5 |
mechanical instabilities and nonuniformities in hereditary sarcomere myopathies | 16 |
Acute exercise modifies titin phosphorylation and increases cardiac myofilament stiffness | 26 |
Lengthdependent changes in contractile dynamics are blunted due to cardiac myosin binding proteinC ablation | 34 |
different at heart | 45 |
functional variance among individual cardiomyocytes as a trigger of FHCphenotype development | 54 |
Proteasome inhibition slightly improves cardiac function in mice with hypertrophic cardiomyopathy | 69 |
Remodeling of the heart in hypertrophy in animal models with myosin essential light chain mutations | 77 |
Alterations in thin filament length during postnatal skeletal muscle development and aging in mice | 102 |
OGlcNAcylation contractile protein modifications and calcium affinity in skeletal muscle | 108 |
Pseudoacetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performance | 115 |
Skeletal muscle myofilament adaptations to aging disease and disuse and their effects on whole muscle performance in older adult humans | 129 |
Altered crossbridge properties in skeletal muscle dystrophies | 144 |
implications for interpreting reflection patterns | 153 |
Back cover | 162 |
Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca2+sensitivity in the pathogenesis of cardiomyopat... | 89 |
Common terms and phrases
actin activation active stretching alterations atrophy Biol Biophys Ca2+ Ca2+-sensitivity calcium cardiac muscle cardiac troponin Cardiol cardiomyocytes Cell Chem Circ cMyBP-C contractile proteins cross-bridge DCM patients decreased dilated cardiomyopathy disease disuse Drosophila dysfunction effects exercise expression familial hypertrophic Figure flight muscle force-pCa gene heart failure Herzog human hypertrophic cardiomyopathy increased interaction isoforms isometric force Kazmierczak King’s College London length-dependent changes light chain long SL mechanisms MLC2 modulation molecular Motil muscle fibers MyHC myocardium myocytes myofibrillar myofibrils myosin binding myosin head myosin heavy chain nebulin O-GlcNAc O-GlcNAcylation observed Ochala oxidative stress phenotype phosphorylation Physiol physiological PPCM proteasome reduced regulation remodeling samples sarcomere length non-uniformity sedentary short SL shortening single fiber soleus stiffness stretch striated muscle structure studies Tg-A43 mice Tg-WT thin filament thin filament lengths tion tissue titin transgenic tropomyosin uncoupling velocity ventricular whole muscle