Genome Mining and Marine Microbial Natural ProductsKui Hong, Changsheng Zhang, Alan Dobson Two review papers, eight research articles, and one brief report were published in this Special Issue. They showed the rich resources that are present within the genomes of marine microorganisms and discussed the use of recently developed tools and technologies to exploit this genetic richness. Examples include the rational supply of precursors according to the relevant biosynthetic pathway and stress driven discovery together with the use of histone deacetylase inhibitors to facilitate the discovery of new bioactive molecules with potential biopharmaceutical applications. We believe that the content of this Special Issue reflects the current state-of-the-art research in this area and highlights the interesting strategies that are being employed to uncover increasing numbers of exciting novel compounds for drug discovery from marine genetic resources. |
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16S rRNA acid actinomycete activity addition adociasulfates albicans analysis antarctica antibacterial activity antibiotic archaea aureus Bacillus bacteria bioactive biosynthetic gene cluster carotenoid cell characterization Chem chemical China coli communities compared compounds concentration configuration containing correlations CrossRef CrossRef][PubMed culture cyclization cytotoxicities derivatives detected determined discovery displayed diversity Drugs environment enzymes extract Figure fungus further gene cluster genome HMBC HPLC identified indicated inhibition involved isolated known marine marine Streptomyces marine-derived medium method microbial Microbiol moiety molecular natural products novel obtained pathway Penicillium peptides performed positive potential presence Prod PTMs PubMed reported resistance respectively revealed ring salinity secondary metabolites sequences showed shown similar SMBGCs species spectra spectrum sponge strains Streptomyces sp structure subtilis suggested Supplementary Table ug/mL values Wang Zhang Zone